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Evidence suggests Iron mayincreaseFerritin level.
134 studies (202 claims)
Moderate consensus
Typical effective dose 60 (30–100) mgacross 58 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| fortification with iron plus other micronutrients | Increases - improves ferritin concentration | ferritin concentration | Human | general population | Iron doses ranged from 4.4 mg to 55 mg/day. | Fortification of condiments and seasonings with iron for preventing anaemia and improving health.cited 11× |
| fortification with iron | Increases - increases ferritin concentration | ferritin concentration | Human | general population | Iron doses ranged from 4.4 mg to 55 mg/day. | Fortification of condiments and seasonings with iron for preventing anaemia and improving health.cited 11× |
| two capsules of daily iron supplement, containing 34 mg of ferrous sulfate | No effect - had similar | ferritin at 35 weeks | Human | iron-deficient women in singleton pregnancies | 34 mg ferrous sulfate (one or two capsules daily). | Iron supplementation in singleton pregnancy: Is there a benefit to doubling the dose of elemental iron in iron-deficient pregnant women? a randomized controlled trial.cited 11× |
| one capsule of daily iron supplement, containing 34 mg of ferrous sulfate | No effect - had similar | ferritin at 35 weeks | Human | iron-deficient women in singleton pregnancies | 34 mg ferrous sulfate (one or two capsules daily). | Iron supplementation in singleton pregnancy: Is there a benefit to doubling the dose of elemental iron in iron-deficient pregnant women? a randomized controlled trial.cited 11× |
| iron supplements (0, 1, or 2 mg · kg(-1) · day(-1)) | No effect - there was a significant difference in | ferritin | Human | marginally LBW infants (2000-2500 g) | 0, 1, or 2 mg/kg/day. | Iron supplementation until 6 months protects marginally low-birth-weight infants from iron deficiency during their first year of life.cited 24× |
| daily supplement of 30 mg/day of elemental iron as ferrous sulfate | No effect - no difference was found | ferritin concentration | Human | schoolchildren with low iron stores as assessed by serum ferritin concentration but without anemia | 30 mg/day of elemental iron | Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial.cited 32× |
| daily supplement of 30 mg/day of elemental iron as iron bis-glycinate chelate | No effect - no difference was found | ferritin concentration | Human | schoolchildren with low iron stores as assessed by serum ferritin concentration but without anemia | 30 mg/day of elemental iron | Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial.cited 32× |
| Supplementing with 30 mg/d of elementary iron, either as ferrous sulfate or iron bis-glycinate chelate for 90 days | Increases - showed positive effects on increasing | ferritin concentration | Human | schoolchildren with low iron stores | 30 mg/day of elemental iron | Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial.cited 32× |
| iron bis-glycinate chelate | Increases - was higher | ferritin concentration | Human | the group that received bis-glycinate chelate iron | 30 mg/day of elemental iron | Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial.cited 32× |
| daily supplementation with iron bis-glycinate chelate | Increases - increased significantly | ferritin concentration | Human | schoolchildren with iron deficiency but without anemia | 30 mg/day of elemental iron | Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial.cited 32× |
| iron deficiency anemia | Decreases - may confirm the diagnosis | low serum ferritin level | Human | — | 3 to 6 mg/kg of elemental iron per day (for treatment, not dietary counseling specifically). | Iron Deficiency Anemia: An Updated Review.cited 24× |
| double dose of daily iron | No effect - no significant differences | ferritin at 32 weeks | Human | iron-deficient women with twin gestations | 34 mg of ferrous sulfate (single or double dose daily). | Iron Supplementation in Twin Pregnancy - The Benefit of Doubling the Iron Dose in Iron Deficient Pregnant Women: A Randomized Controlled Trial.cited 5× |
| doubling the daily dose of iron supplement | Increases - increases | ferritin | Human | iron-deficient women with twin pregnancies | 34 mg of ferrous sulfate (single or double dose daily). | Iron Supplementation in Twin Pregnancy - The Benefit of Doubling the Iron Dose in Iron Deficient Pregnant Women: A Randomized Controlled Trial.cited 5× |
| iron-biofortified beans | Increases - significant improvements | ferritin | Human | 55 women aged 18-27 y with low iron status (serum ferritin <20 µg/L) | Daily consumption of iron-biofortified beans (86.1 ppm iron) vs. comparison beans (50.1 ppm iron). | Changes in Iron Status Are Related to Changes in Brain Activity and Behavior in Rwandan Female University Students: Results from a Randomized Controlled Efficacy Trial Involving Iron-Biofortified Beans.cited 21× |
| iron-biofortified beans (Fe-Beans) | Increases - significantly greater increases in | log serum ferritin | Human | Rwandan women | Fe-Beans (86 mg Fe/kg) or Control-Beans (50 mg Fe/kg), consumed twice daily. | Consuming Iron Biofortified Beans Increases Iron Status in Rwandan Women after 128 Days in a Randomized Controlled Feeding Trial.cited 86× |
| intermittent administration (IA) of intravenous iron | Increases - increased | serum ferritin (SF) levels | Human | maintenance hemodialysis (MHD) patients in Group two (G2) | 100 mg sucrose iron agents per session (continuous: every HD session; intermittent: once weekly), totaling 1000 mg. | Effect of frequency of intravenous iron administration on hemoglobin variability in maintenance hemodialysis patients.cited 5× |
| intermittent administration (IA) of intravenous iron | Increases - increased | serum ferritin (SF) levels | Human | maintenance hemodialysis (MHD) patients in Group two (G2) | 100 mg sucrose iron agents per session (continuous: every HD session; intermittent: once weekly), totaling 1000 mg. | Effect of frequency of intravenous iron administration on hemoglobin variability in maintenance hemodialysis patients.cited 5× |
| continuous administration (CA) of intravenous iron | Increases - increased | serum ferritin (SF) levels | Human | maintenance hemodialysis (MHD) patients in Group one (G1) | 100 mg sucrose iron agents per session (continuous: every HD session; intermittent: once weekly), totaling 1000 mg. | Effect of frequency of intravenous iron administration on hemoglobin variability in maintenance hemodialysis patients.cited 5× |
| continuous administration (CA) of intravenous iron | Increases - increased | serum ferritin (SF) levels | Human | maintenance hemodialysis (MHD) patients in Group one (G1) | 100 mg sucrose iron agents per session (continuous: every HD session; intermittent: once weekly), totaling 1000 mg. | Effect of frequency of intravenous iron administration on hemoglobin variability in maintenance hemodialysis patients.cited 5× |
| twice weekly oral iron therapy | No effect - similar | ferritin levels | Human | Jordanian children aged between 6 and 60 months with Hb estimate less than 11 gm/dl | Single weekly dose, two doses weekly, and daily dose (specific amounts not provided). | Comparison between once weekly, twice weekly, and daily oral iron therapy in Jordanian children suffering from iron deficiency anemia.cited 7× |
| twice weekly oral iron therapy | Increases - significantly higher | ferritin levels | Human | Jordanian children aged between 6 and 60 months with Hb estimate less than 11 gm/dl | Single weekly dose, two doses weekly, and daily dose (specific amounts not provided). | Comparison between once weekly, twice weekly, and daily oral iron therapy in Jordanian children suffering from iron deficiency anemia.cited 7× |
| daily oral iron therapy | No effect - similar | ferritin levels | Human | Jordanian children aged between 6 and 60 months with Hb estimate less than 11 gm/dl | Single weekly dose, two doses weekly, and daily dose (specific amounts not provided). | Comparison between once weekly, twice weekly, and daily oral iron therapy in Jordanian children suffering from iron deficiency anemia.cited 7× |
| daily oral iron therapy | Increases - significantly higher | ferritin levels | Human | Jordanian children aged between 6 and 60 months with Hb estimate less than 11 gm/dl | Single weekly dose, two doses weekly, and daily dose (specific amounts not provided). | Comparison between once weekly, twice weekly, and daily oral iron therapy in Jordanian children suffering from iron deficiency anemia.cited 7× |
| directly observed iron-folic acid (IFA) supplementation | No effect - mean increase in serum ferritin level was similar | mean serum ferritin level | Human | pregnant women in a rural setting of north India | Not specified in the abstract. | Effect of directly observed oral iron supplementation during pregnancy on iron status in a rural population in Haryana: A randomized controlled trial.cited 13× |
| oral iron supplementation (one tablet of ferrous gluconate (37.5 mg of elemental iron) daily) | Decreases - reduced time to recovery to baseline ferritin levels | recovery of ferritin level to baseline | Human | blood donors with low ferritin (≤26 ng/mL) | 37.5 mg elemental iron (as ferrous gluconate) daily. | Oral iron supplementation after blood donation: a randomized clinical trial.cited 120× |
| oral iron supplementation (one tablet of ferrous gluconate (37.5 mg of elemental iron) daily) | Decreases - reduced time to recovery to baseline ferritin levels | recovery of ferritin level to baseline | Human | blood donors with higher ferritin (>26 ng/mL) | 37.5 mg elemental iron (as ferrous gluconate) daily. | Oral iron supplementation after blood donation: a randomized clinical trial.cited 120× |
| iron complex administration | Increases - were slightly increased | ferritin levels | Human | patients with HF | Not specified | Oral iron supplementation in patients with heart failure: a systematic review and meta-analysis.cited 7× |
| donkey bone collagen peptide iron chelate (DPI) | Increases - significantly increased | serum ferritin levels | Animal | immunosuppressed mice | — | Interventional Effect of Donkey Bone Collagen Peptide Iron Chelate on Cyclophosphamide Induced Immunosuppressive Mice. |
| donkey bone collagen peptide iron chelate (DPI) | Increases - significantly increased | serum ferritin levels | Animal | immunosuppressed mice | — | Interventional Effect of Donkey Bone Collagen Peptide Iron Chelate on Cyclophosphamide Induced Immunosuppressive Mice. |
| oral iron syrup (3 mg/kg/day elemental iron) plus one sesame jaggery ball (containing 60 g of sesame seeds and jaggery each) | Increases - increased | serum ferritin levels | Human | children aged 6-11 years diagnosed with moderate iron deficiency anemia | 3 mg/kg/day elemental iron syrup + one sesame jaggery ball (60g sesame seeds and 60g jaggery) daily. | Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial.cited 1× |
| oral iron syrup (3 mg/kg/day elemental iron) | Increases - increased | serum ferritin levels | Human | children aged 6-11 years diagnosed with moderate iron deficiency anemia | 3 mg/kg/day elemental iron syrup + one sesame jaggery ball (60g sesame seeds and 60g jaggery) daily. | Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial.cited 1× |
| liposomal iron pyrophosphate/ascorbic acid | Increases - significant positive effects | ferritin levels | Human | pregnant women with iron deficiency anaemia | Not specified | Liposomal ferric pyrophosphate and ascorbic acid supplementation in pregnant women with iron deficiency anaemia: haematochemical, obstetric, neonatal and psychological outcomes in a prospective observational study.cited 5× |
| iron supplementation | Increases - significantly increased | ferritin | Human | iron-deficient patients on maintenance hemodialysis (MHD) | Oral iron (50 mg sodium ferrous citrate daily) or intravenous iron (40 mg saccharated ferric oxide weekly). | Oral Versus Intravenous Iron Supplementation for the Treatment of Iron Deficiency Anemia in Patients on Maintenance Hemodialysis-Effect on Fibroblast Growth Factor-23 Metabolism.cited 24× |
| iron supplementation | Increases - increased | ferritin | Human | nonanemic iron-deficient women with unexplained fatigue | 80 mg elemental iron (as ferrous sulfate) daily. | Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial.cited 111× |
| iron supplementation (50 mg elemental iron/daily) | Increases - significantly increased | ferritin | Human | mothers with postpartum depression (PPD) | 50 mg elemental iron daily. | The efficacy of early iron supplementation on postpartum depression, a randomized double-blind placebo-controlled trial.cited 34× |
| iron supplementation (50 mg elemental iron/daily) | Increases - was higher | ferritin | Human | iron-treated group | 50 mg elemental iron daily. | The efficacy of early iron supplementation on postpartum depression, a randomized double-blind placebo-controlled trial.cited 34× |
| iron supplementation | Decreases - had lower median | ferritin | Human | children with CM or SMA and iron-deficient community children | Not specified | Comparison of iron status 28 d after provision of antimalarial treatment with iron therapy compared with antimalarial treatment alone in Ugandan children with severe malaria.cited 10× |
| iron supplementation | Increases - was associated with improvement in ferritin in both adjusted and unadjusted analyses | ferritin | Human | children living with HIV and mild-to-moderate anaemia in Uganda | 12.5 mg ferrous sulphate daily for children aged 6-23 months; 30.0 mg ferrous sulphate daily for children aged 24 months or older. | Safety and efficacy of iron supplementation with 3 months of daily ferrous sulphate in children living with HIV and mild-to-moderate anaemia in Uganda: a double-blind, randomised, placebo-controlled trial.cited 1× |
| Iron supplementation | Increases - leads to a rise | ferritin concentration | Human | — | Not specified | SAFETY AND EFFICACY OF INTRAVENOUS ADMINISTRATION OF IRON PREPARATIONS.cited 11× |
| iron supplementation | No effect - ferritin concentrations should not exceed | ferritin concentrations | Human | patients with CKD | Not specified | Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review.cited 206× |
| iron supplementation | No effect - ferritin concentrations should not exceed | ferritin concentrations | Human | patients with CKD | Not specified | Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review.cited 206× |
| iron supplementation | Increases - treatment targets for ID included | serum ferritin | Human | — | Not specified | Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review.cited 206× |
| iron supplementation | Increases - treatment targets for ID included | serum ferritin | Human | — | Not specified | Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review.cited 206× |
| iron supplementation | No effect - should be considered | ferritin cut-off | Human | young athletes | Not specified | Urinary hepcidin identifies a serum ferritin cut-off for iron supplementation in young athletes: a pilot study.cited 7× |
| iron supplementation | No effect - no significant differences | ferritin levels | Human | preterm infants | Not specified | Effects of early parenteral iron combined erythropoietin in preterm infants: A randomized controlled trial.cited 11× |
| iron supplementation combined erythropoietin | No effect - no significant differences | ferritin levels | Human | preterm infants | Not specified | Effects of early parenteral iron combined erythropoietin in preterm infants: A randomized controlled trial.cited 11× |
| iron supplementation | No effect - No significant alterations | ferritin levels | Human | Group II patients (anemic H. pylori-infected) | Not specified | Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: effect of treatment.cited 5× |
| iron supplementation and anti-H pylori therapy | Increases - significant increase | ferritin levels | Human | Group I patients (anemic H. pylori-infected) | Not specified | Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: effect of treatment.cited 5× |
| iron supplementation | Decreases - decreased | haemoglobin, ferritin and malonyl dialdehyde levels | Human | iron-deficient female adolescents | 200 mg ferrous fumarate weekly. | Effects of iron supplementation and nutrition education on haemoglobin, ferritin and oxidative stress in iron-deficient female adolescents in Palestine: randomized control trial.cited 11× |
| iron supplementation | Increases - significantly higher | mean ferritin level | Human | supplemented group compared to control | 1 mg/kg/day ferrous sulfate | Effect of iron supplementation on development of iron deficiency anemia in breastfed infants.cited 6× |
| iron supplementation | Increases - increase | serum ferritin | Human | non-anaemic premenopausal female blood donors with iron deficiency | Not specified | A pilot iron substitution programme in female blood donors with iron deficiency without anaemia.cited 37× |
| iron supplementation | Increases - increase in SF concentration/wk | serum ferritin (SF) | Human | — | Not specified (study analyzed effects per gram of iron but did not list exact dosages). | Effect of iron intake on iron status: a systematic review and meta-analysis of randomized controlled trials.cited 50× |
| iron supplementation | Increases - increase in SF concentration/g Fe | serum ferritin (SF) | Human | — | Not specified (study analyzed effects per gram of iron but did not list exact dosages). | Effect of iron intake on iron status: a systematic review and meta-analysis of randomized controlled trials.cited 50× |
| iron supplementation | Decreases - decreased less sharply | serum ferritin (SF) | Human | iron-supplemented groups | Non-supplemented, low (<60 mg/day), moderate (60-100 mg/day), and high (>100 mg/day) iron supplementation. | Effect of different doses of iron supplementation during pregnancy on maternal and infant health.cited 12× |
| iron supplementation | Increases - significantly higher | serum ferritin | Human | blood donors | Not specified in the abstract. | Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors.cited 56× |
| iron supplementation (325 mg/day of ferrous sulphate) | No effect - experienced no changes | serum ferritin (FER) | Human | iron treatment group (ITG) | 325 mg/day of ferrous sulphate. | Iron supplementation prevents a decline in iron stores and enhances strength performance in elite female volleyball players during the competitive season.cited 19× |
| iron supplementation | Increases - significantly improved the mean increase from baseline to delivery for | serum ferritin | Human | pregnant women in Dar es Salaam, Tanzania | 60 mg of iron, administered every 4 weeks. | Iron Supplementation in Iron-Replete and Nonanemic Pregnant Women in Tanzania: A Randomized Clinical Trial.cited 47× |
| iron supplementation | Increases - appears to change more | serum ferritin | Human | — | Not specified | Systematic review of randomized trials of the effect of iron supplementation on iron stores and oxygen carrying capacity in pregnancy.cited 17× |
| oral iron supplementation | Increases - statistically significant increases | serum ferritin levels | Human | pregnant women with non-anemic iron deficiency | Not specified | Systematic review of randomized trials of the effect of iron supplementation on iron stores and oxygen carrying capacity in pregnancy.cited 17× |
| intravenous iron supplementation | Increases - statistically significant increases | serum ferritin levels | Human | pregnant women with iron deficiency anemia | Not specified | Systematic review of randomized trials of the effect of iron supplementation on iron stores and oxygen carrying capacity in pregnancy.cited 17× |
| iron supplementation | No effect - maintained | serum ferritin (FER) | Human | iron treatment group (ITG) | Not specified | Eleven Weeks of Iron Supplementation Does Not Maintain Iron Status for an Entire Competitive Season in Elite Female Volleyball Players: A Follow-Up Study.cited 9× |
| iron supplementation | Increases - increased significantly | serum ferritin concentrations | Human | subjects assigned to SG | 37.4 mg of elemental iron daily | Iron supplementation decreases plasma zinc but has no effect on plasma fatty acids in non-anemic women.cited 5× |
| iron supplementation | No effect - were unchanged | serum ferritin concentrations | Human | CG | 37.4 mg of elemental iron daily | Iron supplementation decreases plasma zinc but has no effect on plasma fatty acids in non-anemic women.cited 5× |
| Iron supplementation | Increases - raised | serum ferritin levels | Human | — | Not specified | Effective nonvaccine interventions to be considered alongside human papilloma virus vaccine delivery.cited 11× |
| oral iron supplements alone | Increases - change in serum ferritin level | serum ferritin level | Human | patients with iron deficiency anemia (IDA) | 100-mg oral iron tablet every 8 hours daily, with or without 200 mg of vitamin C. | The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial.cited 48× |
| oral iron supplements plus vitamin C | Increases - change in serum ferritin level | serum ferritin level | Human | patients with iron deficiency anemia (IDA) | 100-mg oral iron tablet every 8 hours daily, with or without 200 mg of vitamin C. | The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial.cited 48× |
| iron supplementation from the second day after birth | Increases - had higher | serum ferritin | Human | infants at risk of early iron deficiency | Not specified | Effect of iron supplementation from neonatal period on the iron status of6-month-old infants at-risk for early iron deficiency: a randomized interventional trial.cited 12× |
| iron syrup | Increases - improvements | ferritin concentrations | Human | children | 12.5 mg iron daily (as iron syrup or in MNPs). | Effects of iron supplementation on neural indices of habituation in Bangladeshi children.cited 4× |
| weekly iron-folic acid supplementation (WIFAS) | Increases - proved effective in enhancing | serum ferritin concentrations | Human | school-aged children and adolescents | Weekly iron-folic acid supplementation (specific dosage not mentioned). | Weekly iron-folic acid supplementation and its impact on children and adolescents iron status, mental health and school performance: a systematic review and meta-analysis in sub-Saharan Africa. |
| weekly iron-folic acid supplementation (WIFAS) | Increases - significantly increased | serum ferritin levels | Human | adolescent girls | Weekly iron-folic acid supplementation (specific dosage not mentioned). | Weekly iron-folic acid supplementation and its impact on children and adolescents iron status, mental health and school performance: a systematic review and meta-analysis in sub-Saharan Africa. |
| non-heme iron (FeSO4) | Increases - significantly increased | serum ferritin | Human | women post-RYGB and iron deficient | Not specified in the abstract. | Comparison of Oral Iron Supplement Formulations for Normalization of Iron Status Following Roux-EN-y Gastric Bypass Surgery: a Randomized Trial.cited 21× |
| heme iron (proferrin) | No effect - did not significantly change | serum ferritin | Human | women post-RYGB and iron deficient | Not specified in the abstract. | Comparison of Oral Iron Supplement Formulations for Normalization of Iron Status Following Roux-EN-y Gastric Bypass Surgery: a Randomized Trial.cited 21× |
| early iron supplementation | Decreases - was associated with significantly smaller decreases | serum ferritin levels | Human | low birth weight infants | Not specified (timing ranged from as early as enteral feeding was tolerated to 3 weeks for early supplementation and 4 weeks to about 60 days for late supplementation). | Early and late Iron supplementation for low birth weight infants: a meta-analysis.cited 18× |
| iron supplementation, 66 mg elemental iron daily as ferrous fumarate | Increases - had higher | cord S-ferritin levels | Human | newborns to iron treated mothers | 66 mg elemental iron daily as ferrous fumarate. | Iron supplementation in pregnant Danish women revisited: Effects on prepartum and postpartum iron deficiency, anemia, serum erythropoietin; including iron status, erythropoietin and anthropometrics in newborns. A randomized, placebo-controlled study.cited 4× |
| iron supplementation, 66 mg elemental iron daily as ferrous fumarate | Increases - had higher | serum (S)-ferritin | Human | the iron group | 66 mg elemental iron daily as ferrous fumarate. | Iron supplementation in pregnant Danish women revisited: Effects on prepartum and postpartum iron deficiency, anemia, serum erythropoietin; including iron status, erythropoietin and anthropometrics in newborns. A randomized, placebo-controlled study.cited 4× |
| oral iron supplementation | Increases - increased | ferritin | Human | ADHR patients | Started at 65 mg daily, titrated based on fasting serum iron concentration. | Oral Iron Replacement Normalizes Fibroblast Growth Factor 23 in Iron-Deficient Patients With Autosomal Dominant Hypophosphatemic Rickets.cited 34× |
| Oral iron supplementation | No effect - resulted in unchanged | ferritin levels | Human | candidates for metabolic and bariatric surgery | Chronic dosing of oral supplements, megadoses of oral supplements, intramuscular injection, intravenous infusion, and mixed methods. | Preoperative Micronutrient Repletion Strategies in Metabolic and Bariatric Surgery: A Systematic Review.cited 2× |
| Oral iron supplementation | Decreases - decreased | ferritin levels | Human | candidates for metabolic and bariatric surgery | Chronic dosing of oral supplements, megadoses of oral supplements, intramuscular injection, intravenous infusion, and mixed methods. | Preoperative Micronutrient Repletion Strategies in Metabolic and Bariatric Surgery: A Systematic Review.cited 2× |
| Iron infusion | Increases - increased | ferritin levels | Human | candidates for metabolic and bariatric surgery | Chronic dosing of oral supplements, megadoses of oral supplements, intramuscular injection, intravenous infusion, and mixed methods. | Preoperative Micronutrient Repletion Strategies in Metabolic and Bariatric Surgery: A Systematic Review.cited 2× |
| oral iron supplementation (OIS) | Increases - increases | serum ferritin | Human | healthy adult athletes | 16 to 100 mg of elementary iron daily | Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials.cited 6× |
| oral iron supplementation (OIS) | Increases - Increase in serum ferritin concentration after OIS was evident | serum ferritin concentration | Human | subjects with initial pre-supplementation serum ferritin concentration ≤ 12 µg/l | 16 to 100 mg of elementary iron daily | Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials.cited 6× |
| oral iron supplementation (OIS) | No effect - only minimal, if any effect, was observed | serum ferritin concentration | Human | subjects with higher pre-supplementation serum ferritin concentration | 16 to 100 mg of elementary iron daily | Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials.cited 6× |
| divalent iron | Increases - had significantly higher levels | HCT, HGB, and ferritin | Human | pregnant women | — | The Critical Role of the Early Evaluation of Iron and Vitamin B12 Deficiency in Pregnancy. |
| iron (6 mg · kg · day) and vitamin E (18 mg/day) | Increases - returned to normal | average serum ferritin level | Human | iron-deficient infants and toddlers | 6 mg/kg/day of iron with or without 18 mg/day of vitamin E. | Effect of Vitamin E With Therapeutic Iron Supplementation on Iron Repletion and Gut Microbiome in US Iron Deficient Infants and Toddlers.cited 49× |
| iron therapy (6 mg · kg · day) plus placebo | Increases - returned to normal | average serum ferritin level | Human | iron-deficient infants and toddlers | 6 mg/kg/day of iron with or without 18 mg/day of vitamin E. | Effect of Vitamin E With Therapeutic Iron Supplementation on Iron Repletion and Gut Microbiome in US Iron Deficient Infants and Toddlers.cited 49× |
| IV iron sucrose | Increases - was significantly higher | serum ferritin | Human | ND-CKD patients | HIP 11 mg orally 3 times per day; IV iron sucrose 200 mg monthly. | Heme iron polypeptide for the treatment of iron deficiency anemia in non-dialysis chronic kidney disease patients: a randomized controlled trial.cited 24× |
| oral Heme Iron Polypeptide (HIP) | No effect - was | serum ferritin | Human | ND-CKD patients | HIP 11 mg orally 3 times per day; IV iron sucrose 200 mg monthly. | Heme iron polypeptide for the treatment of iron deficiency anemia in non-dialysis chronic kidney disease patients: a randomized controlled trial.cited 24× |
| Use of supplementary non-heme iron | Increases - was positively associated with | serum ferritin | Human | individuals who underwent RYGB | 45 mg/d of supplementary non-heme iron. | Influence of diet and supplements on iron status after gastric bypass surgery.cited 14× |
| Dietary intake of heme iron | Increases - was favorably associated with | ferritin | Human | individuals who underwent RYGB | 45 mg/d of supplementary non-heme iron. | Influence of diet and supplements on iron status after gastric bypass surgery.cited 14× |
| early iron (EI) supplementation (2 mg/kg/day elemental iron) at 2 weeks postnatal age | Increases - significant increase | ferritin at 6 weeks compared with 2 weeks | Human | preterm very low birth weight (VLBW) infants | 2 mg/kg/day elemental iron | Early versus late enteral prophylactic iron supplementation in preterm very low birth weight infants: a randomised controlled trial.cited 21× |
| early iron (EI) supplementation (2 mg/kg/day elemental iron) at 2 weeks postnatal age | Increases - significantly higher | serum ferritin level at 12 weeks | Human | preterm very low birth weight (VLBW) infants | 2 mg/kg/day elemental iron | Early versus late enteral prophylactic iron supplementation in preterm very low birth weight infants: a randomised controlled trial.cited 21× |
| late iron (LI) supplementation at 6 weeks postnatal age | Decreases - significant decrease | ferritin at 6 weeks compared with 2 weeks | Human | preterm very low birth weight (VLBW) infants | 2 mg/kg/day elemental iron | Early versus late enteral prophylactic iron supplementation in preterm very low birth weight infants: a randomised controlled trial.cited 21× |
| micronutrient powder containing prophylactic iron | Increases - significantly higher | serum ferritin levels | Human | children who remained at the end of the intervention | 400 μg Vitamin A (daily, as part of a micronutrient powder). | Impact of iron fortification on anaemia and iron deficiency among pre-school children living in Rural Ghana.cited 7× |
| intermittent oral iron supplementation, alone or in combination with other nutrients | Increases - improves the concentration of | ferritin | Human | menstruating women | 1-3 times weekly (non-consecutive days), with weekly elemental iron doses varying (some trials used ≤60 mg/week, others >60 mg/week). | Intermittent iron supplementation for reducing anaemia and its associated impairments in menstruating women.cited 53× |
| 60 mg iron and 0.4 mg folic acid | Increases - considerable increases | iron status in Hb, plasma iron and ferritin | Human | anemic pregnant women | 60 mg iron as ferrous sulfate daily, with some groups also receiving 0.4 mg folic acid and/or 2.0 mg retinol. | A combination of iron and retinol supplementation benefits iron status, IL-2 level and lymphocyte proliferation in anemic pregnant women.cited 22× |
| 60 mg iron as ferrous sulfate | Increases - considerable increases | iron status in Hb, plasma iron and ferritin | Human | anemic pregnant women | 60 mg iron as ferrous sulfate daily, with some groups also receiving 0.4 mg folic acid and/or 2.0 mg retinol. | A combination of iron and retinol supplementation benefits iron status, IL-2 level and lymphocyte proliferation in anemic pregnant women.cited 22× |
| intermittent iron supplementation (alone or with any other vitamins and minerals) | Increases - improved the concentration of | ferritin | Human | menstruating women | Intermittent regimens (1-3 times weekly, non-consecutive days), with some studies using ≤60 mg elemental iron per week. | Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women.cited 47× |
| Intermittent iron supplementation | Increases - significantly improves | ferritin concentration | Human | children | Not specified | Interventions to address maternal and childhood undernutrition: current evidence.cited 12× |
| intermittent iron supplementation | Increases - have higher | ferritin concentrations | Human | children | Intermittent supplementation (one, two, or three times a week on non-consecutive days); total weekly dose of elemental iron varied. | Intermittent iron supplementation for improving nutrition and development in children under 12 years of age.cited 103× |
| intermittent iron supplementation | No effect - was as effective as daily supplementation in improving | ferritin concentrations | Human | children | Intermittent supplementation (one, two, or three times a week on non-consecutive days); total weekly dose of elemental iron varied. | Intermittent iron supplementation for improving nutrition and development in children under 12 years of age.cited 103× |
| intravenous iron | Increases - increased | Ferritin levels | Human | anaemic adults undergoing surgery | Not specified (varied by study, including oral and intravenous forms). | Iron therapy for preoperative anaemia.cited 57× |
| intravenous iron | Increases - increased | Ferritin levels | Human | anaemic adults undergoing surgery | Not specified (varied by study, including oral and intravenous forms). | Iron therapy for preoperative anaemia.cited 57× |
| intravenous iron supplementation | Increases - significantly higher values | ferritin | Human | non-anemic repeat adult blood donors with iron deficiency (ferritin ≤ 50 µg/L) | Single intravenous dose of 800 mg iron-carboxymaltose. | The effects of intravenous iron supplementation on fatigue and general health in non-anemic blood donors with iron deficiency: a randomized placebo-controlled superiority trial.cited 16× |
| intravenous iron supplementation | Increases - resulted in increase | ferritin levels | Human | repeat blood donors with low iron stores | Single intravenous dose of 800 mg iron-carboxymaltose. | The effects of intravenous iron supplementation on fatigue and general health in non-anemic blood donors with iron deficiency: a randomized placebo-controlled superiority trial.cited 16× |
| intravenous iron supplementation | No effect - share similar efficacy | serum ferritin (SF) | Human | patients with renal anaemia | Low-frequency high-dose (1-2 doses, >200 mg/dose) and high-frequency low-dose (4-5 doses, ≤200 mg/dose). | Efficacy and safety of intravenous iron with different frequencies for renal anaemia: A systematic review and meta-analysis. |
| iron amino acid chelated (AACI) preparation | Increases - had increase in | serum ferritin | Human | school-age children with iron deficiency anemia | Once daily at bedtime (specific dosage not provided). | Amino Acid Chelated Iron Versus Ferric Ammonium Citrate on Iron Status in Egyptian Children with Iron Deficiency Anemia: A Randomized Controlled Study.cited 1× |
| intravenous iron(III)-hydroxide sucrose complex | Increases - showed higher | serum ferritin levels 1 month later | Human | patients undergoing cardiopulmonary bypass surgery | Intravenous iron(III)-hydroxide sucrose complex (three doses of 100 mg/24 h during hospitalization) or oral ferrous fumarate (1 pill/24 h pre- and postoperatively and for 1 month after discharge). | The effect of intravenous and oral iron administration on perioperative anaemia and transfusion requirements in patients undergoing elective cardiac surgery: a randomized clinical trial.cited 75× |
| intravenous iron(III)-hydroxide sucrose complex | Increases - showed higher | serum ferritin levels at hospital discharge | Human | patients undergoing cardiopulmonary bypass surgery | Intravenous iron(III)-hydroxide sucrose complex (three doses of 100 mg/24 h during hospitalization) or oral ferrous fumarate (1 pill/24 h pre- and postoperatively and for 1 month after discharge). | The effect of intravenous and oral iron administration on perioperative anaemia and transfusion requirements in patients undergoing elective cardiac surgery: a randomized clinical trial.cited 75× |
| control diet with iron supplementation | Increases - increased significantly | serum ferritin concentrations | Human | participants assigned to the SG | Not specified (low-dose iron supplementation mentioned). | A randomized controlled trial in young women of the effects of consuming pork meat or iron supplements on nutritional status and feeling of well-being.cited 13× |
| iron bisglycinate chelate (FeBC) | Increases - significantly increased | ferritin levels | Human | anemic children aged 1 to 13 years diagnosed with IDA | 3.0 mg iron/kg body weight/day for both FeBC and FeP. | Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial.cited 11× |
| iron-free prenatal vitamin-mineral supplement plus 27 mg of iron (combined groups) | No effect - no significant differences | ferritin | Human | lactating women with elevated CRP at baseline | 27 mg of iron daily (either with or between meals) | Effect of iron supplementation during lactation on maternal iron status and oxidative stress: A randomized controlled trial.cited 10× |
| iron-free prenatal vitamin-mineral supplement plus 27 mg of iron (combined groups) | Increases - increased more | ferritin | Human | lactating women without elevated CRP at baseline | 27 mg of iron daily (either with or between meals) | Effect of iron supplementation during lactation on maternal iron status and oxidative stress: A randomized controlled trial.cited 10× |
| ferric carboxymaltose (FCM) vs iron polymaltose (IPM) | No effect - not between | mean ferritin level differences | Human | pregnant women with IDA | Single IV infusion of 1000mg FCM over 15 minutes, single IV infusion of 1000mg IPM over 2 hours, or 325mg daily oral ferrous sulphate until delivery. | A Prospective Randomised Controlled Trial of a Single Intravenous Infusion of Ferric Carboxymaltose vs Single Intravenous Iron Polymaltose or Daily Oral Ferrous Sulphate in the Treatment of Iron Deficiency Anaemia in Pregnancy.cited 36× |
| iron polymaltose (IPM) | Increases - significantly higher | mean ferritin level differences | Human | pregnant women with IDA | Single IV infusion of 1000mg FCM over 15 minutes, single IV infusion of 1000mg IPM over 2 hours, or 325mg daily oral ferrous sulphate until delivery. | A Prospective Randomised Controlled Trial of a Single Intravenous Infusion of Ferric Carboxymaltose vs Single Intravenous Iron Polymaltose or Daily Oral Ferrous Sulphate in the Treatment of Iron Deficiency Anaemia in Pregnancy.cited 36× |
| i.v. iron | Increases - found to be superior in increasing | ferritin and transferrin saturation (TSAT) levels | Human | non-hemodialysis-dependent patients with chronic kidney disease (CKD) | Not specified | Intravenous versus oral iron for treatment of iron deficiency in non-hemodialysis-dependent patients with chronic kidney disease.cited 9× |
| i.v. iron | Increases - significantly increased | serum levels of ferritin and TSAT | Human | non-hemodialysis-dependent patients with chronic kidney disease (CKD) | Not specified | Intravenous versus oral iron for treatment of iron deficiency in non-hemodialysis-dependent patients with chronic kidney disease.cited 9× |
| oral iron | Decreases - found a significant decrease from baseline in | ferritin and TSAT | Human | non-hemodialysis-dependent patients with chronic kidney disease (CKD) | Not specified | Intravenous versus oral iron for treatment of iron deficiency in non-hemodialysis-dependent patients with chronic kidney disease.cited 9× |
| alcohol (8-12 mL/kg/day) by gavage and iron (1500 mg/kg) in diet | Increases - significantly increased | levels of serum ferritin | Animal | male rats | 8 × 10^8 CFU/kg/day | Effects of Lactobacillus casei on Iron Metabolism and Intestinal Microflora in Rats Exposed to Alcohol and Iron.cited 6× |
| Iron Sucrose i.v. 200 mg, once a week, for 5 weeks | Increases - increased significantly | ferritin | Human | anemic heart failure patients with preserved renal function, low transferrin saturation (TSat) and low-to-moderately elevated ferritin levels | Iron Sucrose i.v. 200 mg once a week for 5 weeks; ferrous sulfate 200 mg p.o. three times daily for 8 weeks. | IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia.cited 174× |
| intravenous (IV) iron sucrose | Increases - A statistically significant increase in the mean Hb and serum ferritin levels was observed | hemoglobin (Hb) and serum ferritin levels | Human | pregnant women with moderate to severe IDA in the second or third trimester | Not specified in the abstract. | Evaluation of therapeutic response and tolerability to intravenous iron sucrose and ferric carboxymaltose among pregnant women with iron?deficiency anemia: A 6?year experience in a tertiary care center. |
| intravenous iron sucrose | Increases - efficacy in improving | serum ferritin | Human | anemic pregnant women | Not specified | Is intravenous iron sucrose the treatment of choice for pregnant anemic women?cited 8× |
| 20 mg dose of iron IV at the end of each session of HD as iron maintenance | No effect - that is not shown | CHr with serum ferritin | Human | 36 patients | 20 mg IV iron at the end of each hemodialysis session. | Very low doses of direct intravenous iron in each session as maintenance therapy in hemodialysis patients.cited 6× |
| 20 mg dose of iron IV at the end of each session of HD as iron maintenance | No effect - showed not an increased | serum ferritin | Human | 13 patients who did not receive the iron prior to the study | 20 mg IV iron at the end of each hemodialysis session. | Very low doses of direct intravenous iron in each session as maintenance therapy in hemodialysis patients.cited 6× |
| iron supplements (0 mg/kg daily) | Decreases - rapid decrease | serum ferritin | Human | low-birth-weight (LBW) infants | 0 (placebo), 1, or 2 mg/kg daily. | Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants.cited 40× |
| haem iron | Increases - more efficacious than | haemoglobin and ferritin concentrations | Human | anaemic children aged 6-12 months | 10.0 mg of elemental iron daily, either as haem or ferrous sulphate. | Haem iron versus ferrous iron salts to treat iron deficiency anaemia in Gambian children: protocol for randomised controlled trial {1}.cited 2× |
| liposomal iron 14 mg (LI14) | Increases - showed significantly higher | ferritin concentrations | Human | healthy pregnant women | Ferrous iron 30 mg, liposomal iron 14 mg (Sideral®), and liposomal iron 28 mg daily. | Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: a randomized control trial.cited 34× |
| liposomal iron 28 mg/daily (LI28) | Increases - showed significantly higher | ferritin concentrations | Human | healthy pregnant women | Ferrous iron 30 mg, liposomal iron 14 mg (Sideral®), and liposomal iron 28 mg daily. | Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: a randomized control trial.cited 34× |
| a combination of Lf and elemental iron | Increases - were found to be increased | serum ferritin (SF) | Human | children with IDA | Not specified in the abstract. | Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review. |
| iron | No effect - assess the effect of | ferritin concentration | Human | — | 60 mg elemental iron as ferrous sulfate or 18 mg ferrous bisglycinate, administered daily. | Is untargeted iron supplementation harmful when iron deficiency is not the major cause of anaemia? Study protocol for a double-blind, randomised controlled trial among non-pregnant Cambodian women.cited 5× |
| iron (60 mg or 80 mg elemental iron) | Increases - were equally effective in normalising | ferritin levels | Human | participants with latent iron deficiency | 60 mg or 80 mg elemental iron daily. | Comparison of two doses of elemental iron in the treatment of latent iron deficiency: efficacy, side effects and blinding capabilities.cited 12× |
| iron deficiency | Decreases - presented reduced | ferritin | Human | infants with IDA | Only one infant was taking prophylactic ferrous sulfate (specific dosage not provided). | Iron deficiency anemia in infants in Sousa (PB), Brazil: an association with nutritional status.cited 2× |
| daily iron intake | Increases - directly correlated | ferritin | Human | infants | Only one infant was taking prophylactic ferrous sulfate (specific dosage not provided). | Iron deficiency anemia in infants in Sousa (PB), Brazil: an association with nutritional status.cited 2× |
| H63D heterozygous homeostatic iron regulator (HFE) gene mutation | Increases - resulted in | ferritin level | Human | Sinhalese man | Not specified | Iron Overload in Histidine-to-Aspartic Acid Substitution at 63 (H63D) Gene Heterozygous Hereditary Hemochromatosis With Erythrocytosis: A Case Report. |
| 60 mg iron as ferrous sulfate | Increases - Considerable increases | ferritin | Human | anemic pregnant women | 60 mg iron daily as ferrous sulfate or NaFeEDTA | Moderate NaFeEDTA and ferrous sulfate supplementation can improve both hematologic status and oxidative stress in anemic pregnant women.cited 11× |
| 60 mg iron as NaFeEDTA | Increases - Considerable increases | ferritin | Human | anemic pregnant women | 60 mg iron daily as ferrous sulfate or NaFeEDTA | Moderate NaFeEDTA and ferrous sulfate supplementation can improve both hematologic status and oxidative stress in anemic pregnant women.cited 11× |
| 60 mg iron as NaFeEDTA | Increases - significantly greater | ferritin | Human | anemic pregnant women | 60 mg iron daily as ferrous sulfate or NaFeEDTA | Moderate NaFeEDTA and ferrous sulfate supplementation can improve both hematologic status and oxidative stress in anemic pregnant women.cited 11× |
| 19 mg of iron pills | Decreases - declined | prevalence of ferritin of less than 12 or less than 26 ng/mL | Human | subjects completing the study | 19 mg or 38 mg of iron once daily after each donation | A randomized, blinded, placebo-controlled trial of education and iron supplementation for mitigation of iron deficiency in regular blood donors.cited 48× |
| iron status (ferritin) information letters | Decreases - declined | prevalence of ferritin of less than 12 or less than 26 ng/mL | Human | subjects completing the study | 19 mg or 38 mg of iron once daily after each donation | A randomized, blinded, placebo-controlled trial of education and iron supplementation for mitigation of iron deficiency in regular blood donors.cited 48× |
| 38 mg of iron pills | Decreases - declined | prevalence of ferritin of less than 12 or less than 26 ng/mL | Human | subjects completing the study | 19 mg or 38 mg of iron once daily after each donation | A randomized, blinded, placebo-controlled trial of education and iron supplementation for mitigation of iron deficiency in regular blood donors.cited 48× |
| daily-supervised administration of iron and folic acid with placebo (control group) | Increases - increased | ferritin levels | Human | adolescent girls who completed 90 doses of daily supplementation | Experimental group: iron (60 mg), folic acid (500 mcg), cyanocobalamin (1000 mcg) daily; control group: IFA (iron 60 mg, folic acid 500 mcg) and placebo daily. | Impact of daily-supervised administration of a package of iron and folic acid and vitamin Bcited 6× |
| daily-supervised administration of iron and folic acid with cyanocobalamin (experimental group) | Increases - increased | ferritin levels | Human | adolescent girls who completed 90 doses of daily supplementation | Experimental group: iron (60 mg), folic acid (500 mcg), cyanocobalamin (1000 mcg) daily; control group: IFA (iron 60 mg, folic acid 500 mcg) and placebo daily. | Impact of daily-supervised administration of a package of iron and folic acid and vitamin Bcited 6× |
| prebiotics or probiotics (especially Lp299v and GOS) with or without oral iron | Increases - lead to improvement | ferritin levels | Human | women | Major interventions included galacto-oligosaccharide, inulin, and specific probiotic strains (e.g., Lactobacillus plantarum 299v, Lactobacillus reuteri, Lactobacillus acidophilus), but exact dosages were not specified. | Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis.cited 2× |
| prebiotics and/or probiotics with or without iron | Increases - led to a significant increase | ferritin levels | Human | WRA | Major interventions included galacto-oligosaccharide, inulin, and specific probiotic strains (e.g., Lactobacillus plantarum 299v, Lactobacillus reuteri, Lactobacillus acidophilus), but exact dosages were not specified. | Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis.cited 2× |
| prebiotics and/or probiotics with or without iron | No effect - did not result in any significant change | hemoglobin, ferritin and fractional iron absorption | Human | children | Major interventions included galacto-oligosaccharide, inulin, and specific probiotic strains (e.g., Lactobacillus plantarum 299v, Lactobacillus reuteri, Lactobacillus acidophilus), but exact dosages were not specified. | Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis.cited 2× |
| pre-pregnancy weekly iron-folic acid (IFA) supplements | Increases - had higher ferritin | ferritin 3 months postpartum | Human | women | Weekly pre-pregnancy supplements: FA (2800 μg), IFA (60 mg Fe + 2800 μg FA), or MM (15 micronutrients, including 60 mg Fe + 2800 μg FA). Daily IFA (60 mg Fe + 400 μg FA) during pregnancy. | Impact of Preconception Micronutrient Supplementation on Anemia and Iron Status during Pregnancy and Postpartum: A Randomized Controlled Trial in Rural Vietnam.cited 33× |
| pre-pregnancy weekly iron-folic acid (IFA) supplements | Increases - significantly higher | prenatal ferritin | Human | women | Weekly pre-pregnancy supplements: FA (2800 μg), IFA (60 mg Fe + 2800 μg FA), or MM (15 micronutrients, including 60 mg Fe + 2800 μg FA). Daily IFA (60 mg Fe + 400 μg FA) during pregnancy. | Impact of Preconception Micronutrient Supplementation on Anemia and Iron Status during Pregnancy and Postpartum: A Randomized Controlled Trial in Rural Vietnam.cited 33× |
| every other day iron supplementation | Increases - increased | ferritin levels | Human | anemic pregnant women | Not specified in the abstract. | Is every other day iron supplementation effective for the treatment of the iron deficiency anemia in pregnancy?cited 6× |
| daily iron intake | Increases - increased | ferritin levels | Human | anemic pregnant women | Not specified in the abstract. | Is every other day iron supplementation effective for the treatment of the iron deficiency anemia in pregnancy?cited 6× |
| oral iron supplementation of 80 mg day(-1) for 3 weeks | Increases - showed higher values | serum ferritin (Ftn) | Human | group A (GA, n=24; Spanish Premier League soccer players) compared to group B (GB, n=11; Spanish Third Division League soccer players) | 80 mg/day | Oral iron treatment has a positive effect on iron metabolism in elite soccer players.cited 7× |
| oral iron supplementation of 80 mg day(-1) for 3 weeks | Increases - showed an increase | serum ferritin (Ftn) | Human | group A (GA, n=24; Spanish Premier League soccer players) | 80 mg/day | Oral iron treatment has a positive effect on iron metabolism in elite soccer players.cited 7× |
| iron-fortified chocolate biscuits | Increases - increased significantly | plasma ferritin | Human | preschool children from rural communities | Not specified (consumed fortified biscuits for 72 days). | Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren.cited 5× |
| parenteral iron | Increases - associated with a more rapid rise | serum ferritin | Human | postpartum period | Not specified | The Use of Parenteral Iron Therapy for the Treatment of Postpartum Anemia.cited 10× |
| weekly iron folic acid (IFA) supplementation with cyanocobalamin (vitamin B12) | Decreases - significant reduction | prevalence of serum ferritin deficiency (<15 ng/ml) | Human | mild and moderate anaemic volunteer adolescent girls (11-18 years) | Group A: iron (100 mg) + folic acid (500 mcg) weekly; Group B: iron (100 mg) + folic acid (500 mcg) + cyanocobalamin (500 mcg for 6 weeks, then 15 mcg for 20 weeks) weekly. | Impact of weekly iron folic acid supplementation with and without vitamin B12 on anaemic adolescent girls: a randomised clinical trial.cited 17× |
| weekly iron folic acid (IFA) supplementation with placebo | Decreases - reduction | prevalence of serum ferritin deficiency (<15 ng/ml) | Human | mild and moderate anaemic volunteer adolescent girls (11-18 years) | Group A: iron (100 mg) + folic acid (500 mcg) weekly; Group B: iron (100 mg) + folic acid (500 mcg) + cyanocobalamin (500 mcg for 6 weeks, then 15 mcg for 20 weeks) weekly. | Impact of weekly iron folic acid supplementation with and without vitamin B12 on anaemic adolescent girls: a randomised clinical trial.cited 17× |
| daily iron supplementation | Increases - mean end point ferritin was 11.64 µg/L greater | ferritin | Human | 2 to 5 year olds | Not specified | Effects of daily iron supplementation in 2- to 5-year-old children: systematic review and meta-analysis.cited 60× |
| daily oral iron supplement (ferrous sulfate + vitamin C) | No effect - no correlation was observed | change in RLS score and ferritin level | Human | Sixteen patients met criteria for definite RLS | Daily oral iron supplement (ferrous sulfate + vitamin C) – exact dosage not specified. | Does Improvement of Low Serum Ferritin Improve Symptoms of Restless Legs Syndrome in a Cohort of Pediatric Patients?cited 19× |
| daily oral iron supplement (ferrous sulfate + vitamin C) | Increases - statistically significantly different | ferritin | Human | 47 patients (age 5-18 years) exhibiting restless legs/restless sleep symptoms and low serum ferritin levels (< 50 ng/mL) | Daily oral iron supplement (ferrous sulfate + vitamin C) – exact dosage not specified. | Does Improvement of Low Serum Ferritin Improve Symptoms of Restless Legs Syndrome in a Cohort of Pediatric Patients?cited 19× |
| daily oral iron supplement (ferrous sulfate + vitamin C) | Increases - significant change | ferritin | Human | Sixteen patients met criteria for definite RLS | Daily oral iron supplement (ferrous sulfate + vitamin C) – exact dosage not specified. | Does Improvement of Low Serum Ferritin Improve Symptoms of Restless Legs Syndrome in a Cohort of Pediatric Patients?cited 19× |
| daily oral iron supplement (ferrous sulfate + vitamin C) | Increases - significant improvement | ferritin levels | Human | children exhibiting restless sleep and RLS symptomatology | Daily oral iron supplement (ferrous sulfate + vitamin C) – exact dosage not specified. | Does Improvement of Low Serum Ferritin Improve Symptoms of Restless Legs Syndrome in a Cohort of Pediatric Patients?cited 19× |
| severe maternal iron deficiency anemia in pregnancy | Decreases - is associated with lower | ferritin levels | Human | infants at birth | Not specified | The interplay between maternal-infant anemia and iron deficiency.cited 11× |
| different iron supplementation protocols in terms of dosage and frequency | No effect - evaluate the impact of | ferritin and haemoglobin levels, gastrointestinal side effects, iron deficiency-related symptoms and donor return | Human | whole blood donors with ferritin levels ≤30 µg/L | 0 mg (placebo), 30 mg, or 60 mg, administered daily or on alternate days. | Ferritin-guided iron supplementation in whole blood donors: optimal dosage, donor response, return and efficacy (FORTE)-a randomised controlled trial protocol.cited 9× |
| i.v. iron (ferric gluconate) combined with rHuEPO | Increases - ferritin increased | ferritin | Human | 148 advanced cancer patients undergoing chemotherapy | Ferric gluconate (125 mg i.v. weekly) or lactoferrin (200 mg/day) | Efficacy and safety of oral lactoferrin supplementation in combination with rHuEPO-beta for the treatment of anemia in advanced cancer patients undergoing chemotherapy: open-label, randomized controlled study.cited 48× |
| oral iron therapy | Increases - should be provided for ≥3 mo | ferritin | Human | in the setting of ID | Oral iron once daily, preferably in the morning; intravenous iron for specific cases (dosage not specified). | Nutritional Strategies for Managing Iron Deficiency in Adolescents: Approaches to a Challenging but Common Problem.cited 2× |
| low-molecular-weight iron dextran (LMW-ID) | Increases - improved | Ferritin efficacy | Human | stable HD patients with adequate iron stores previously treated with ferric gluconate | Not specified (mean amount of iron per week remained stable). | Low-molecular-weight iron dextran in the management of renal anaemia in patients on haemodialysis--the IDIRA Study.cited 3× |
| low-molecular-weight iron dextran (LMW-ID) | Increases - increased | serum ferritin | Human | stable HD patients with adequate iron stores previously treated with ferric gluconate | Not specified (mean amount of iron per week remained stable). | Low-molecular-weight iron dextran in the management of renal anaemia in patients on haemodialysis--the IDIRA Study.cited 3× |
| formula milk fortified with 1.2 mg/100 mL of iron | Increases - showed higher | serum ferritin | Human | Spanish children | 1.2 mg/100 mL or 0.4 mg/100 mL of iron in formula milk. | Does the fortified milk with high iron dose improve the neurodevelopment of healthy infants? Randomized controlled trial.cited 7× |
| combined supplement of 40 mg zinc as zinc gluconate and 40 mg iron as ferrous sulphate | Increases - was effective in raising | Hb and serum ferritin values | Human | women who were iron deficient in early pregnancy | 40 mg elemental iron as ferrous sulphate (control group); 40 mg zinc as zinc gluconate + 40 mg iron as ferrous sulphate (intervention group). | Combined iron and zinc supplementation improves haematologic status of pregnant women in Upper West Region of Ghana.cited 8× |
| combined supplement of 40 mg zinc as zinc gluconate and 40 mg iron as ferrous sulphate | No effect - was not effective in raising | Hb and serum ferritin values | Human | iron sufficient women | 40 mg elemental iron as ferrous sulphate (control group); 40 mg zinc as zinc gluconate + 40 mg iron as ferrous sulphate (intervention group). | Combined iron and zinc supplementation improves haematologic status of pregnant women in Upper West Region of Ghana.cited 8× |
| iron sucrose 100 mg IV | Increases - increased significantly | serum ferritin concentration | Human | anemic, critically ill trauma patients | 100 mg IV iron sucrose thrice weekly | A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness*.cited 68× |
| iron sucrose 100 mg IV | Increases - increased significantly | serum ferritin concentration | Human | anemic, critically ill trauma patients | 100 mg IV iron sucrose thrice weekly | A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness*.cited 68× |
| intravenous iron using the new protocol (400-1400 mg) | Increases - resulting in increases in | ferritin | Human | RYGB patients with ID or anemia | 400-1400 mg intravenous iron (protocol-based). | Management of iron deficiency and anemia after Roux-en-Y gastric bypass surgery: an observational study.cited 18× |
| daily iron supplements | Increases - change scores for Impulsivity and Attention were significantly greater in | plasma ferritin | Human | plasma ferritin improvers | 60 mg or 80 mg elemental iron daily. | A study of the effects of latent iron deficiency on measures of cognition: a pilot randomised controlled trial of iron supplementation in young women.cited 22× |
| daily iron supplements | No effect - change scores for Impulsivity and Attention were significantly greater in | plasma ferritin | Human | non-improvers | 60 mg or 80 mg elemental iron daily. | A study of the effects of latent iron deficiency on measures of cognition: a pilot randomised controlled trial of iron supplementation in young women.cited 22× |
| iron therapy twice daily | Increases - were significantly higher | ferritin levels | Human | female participants aged 18-45 years with hemoglobin < 10 g/dL and serum ferritin < 20 ng/ml | Every other day, once daily, or twice daily iron therapy (specific iron compound and dosage not specified). | Effects of Different Doses of Oral Iron on Hepcidin and Treatment Response in Iron Deficiency Anemia.cited 1× |
| Iron folate group (60 mg elemental iron and folate) | Increases - significantly higher | changes in serum ferritin and body iron | Human | anaemic adolescent schoolgirls without sub-clinical inflammation | 15,000 IU of vitamin A once a week. | Is Iron Supplementation Influenced by Sub-Clinical Inflammation?: A Randomized Controlled Trial Among Adolescent Schoolgirls in Myanmar.cited 12× |
| intra-operative administration of iron isomaltoside | Increases - significantly higher | serum ferritin concentrations at 30 days after TKA | Human | patients undergoing TKA | 1136 ± 225 mg of iron isomaltoside administered intravenously. | Efficacy of intra-operative administration of iron isomaltoside for preventing postoperative anaemia after total knee arthroplasty: A randomised controlled trial.cited 12× |
| iron-fortified lentils (IFLs) | Decreases - exhibited a significantly reduced decline | serum ferritin (sFer) | Human | rural Bangladeshi adolescent girls | 200 g cooked IFLs or non-iron-fortified lentils (NIFLs) 5 days a week, providing ~8.625 mg Fe per serving (IFL) or 2.625 mg Fe (NIFL). | Consumption of Iron-Fortified Lentils Is Protective against Declining Iron Status among Adolescent Girls in Bangladesh: Evidence from a Community-Based Double-Blind, Cluster-Randomized Controlled Trial. |
| administration of iron | Increases - led to a rise in | ferritin | Human | — | 330 mg of ferrous fumarate daily. | Effects of iron supplements in individuals with erythropoietic protoporphyria.cited 1× |
| enteral iron supplementation | Increases - resulted in increased | ferritin concentrations | Human | preterm and low-birth-weight infants | Not specified | Iron supplementation in preterm and low-birth-weight infants: a systematic review of intervention studies.cited 43× |
| enteral iron supplementation | No effect - no effect on | serum ferritin | Human | preterm or LBW infants fed human milk | Not specified | Enteral Iron Supplementation in Preterm or Low Birth Weight Infants: A Systematic Review and Meta-analysis.cited 15× |
| a food-derived dietary supplement containing a low dose of iron and nutrients that increase iron absorption (Blood Builder®/Iron Response®) | Increases - improved | serum ferritin | Human | premenopausal women with nonanemic iron deficiency | 26 mg of iron once daily. | A Food-Derived Dietary Supplement Containing a Low Dose of Iron Improved Markers of Iron Status Among Nonanemic Iron-Deficient Women.cited 2× |
| daily supplementation with 60 mg of elemental iron | Increases - yielded the following results at 1 month after birth: geometric mean maternal plasma ferritin concentration: 32.1 µg/L vs 14.4 µg/L | maternal plasma ferritin concentration | Human | women who received iron vs placebo | 60 mg elemental iron (as ferrous fumarate) daily. | Effect of Daily Antenatal Iron Supplementation on Plasmodium Infection in Kenyan Women: A Randomized Clinical Trial.cited 58× |
| daily supplementation with 60 mg of elemental iron | Increases - yielded the following results at 1 month after birth: geometric mean neonatal plasma ferritin concentration: 163.0 µg/L vs 138.7 µg/L | neonatal plasma ferritin concentration | Human | women who received iron vs placebo | 60 mg elemental iron (as ferrous fumarate) daily. | Effect of Daily Antenatal Iron Supplementation on Plasmodium Infection in Kenyan Women: A Randomized Clinical Trial.cited 58× |
| iron infusion | Decreases - associated with | lower ferritin levels | Human | high responders | Not specified | Short-term effect of preoperative intravenous iron therapy in colorectal cancer patients with anemia: results of a cohort study.cited 33× |
| oral iron treatment | Increases - could improve | iron stores measured serum ferritin | Human | patients with heart failure and iron deficiency | Not specified in the abstract. | Effects and Safety of Oral Iron for Heart Failure with Iron Deficiency: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.cited 1× |
| heme iron polypeptide (HIP) | Decreases - were significantly lower | Serum ferritin levels at 6 months | Human | DPO-treated patients | Two capsules daily of either HIP or ferrous sulphate. | A randomized controlled trial of oral heme iron polypeptide versus oral iron supplementation for the treatment of anaemia in peritoneal dialysis patients: HEMATOCRIT trial.cited 23× |
| early diagnosis of iron deficiency | No effect - is based on | ferritin concentration and transferrin saturation | Human | — | Not specified | Review article: treating-to-target for inflammatory bowel disease-associated anaemia.cited 27× |
| twice weekly iron supplementation | Decreases - significantly lower | ferritin concentrations at delivery | Human | pregnant women | Daily or twice weekly iron supplementation (specific dosage not mentioned) | Impact of twice weekly versus daily iron supplementation during pregnancy on maternal and fetal haematological indices: a randomized clinical trial.cited 6× |
| iron or micronutrient supplementation | No effect - included | serum ferritin thresholds | Human | pregnancy | Not specified. | Serum ferritin thresholds for the diagnosis of iron deficiency in pregnancy: a systematic review.cited 90× |
| daily oral iron supplementation | No effect - had no significant effect | serum ferritin level | Human | exclusively breastfed infants | Not specified | Effect of Daily Iron Supplementation in Healthy Exclusively Breastfed Infants: A Systematic Review with Meta-Analysis.cited 13× |
| combined treatment with oral and subcutaneous iron chelators (50-100 mg/kg/day of oral deferiprone (DFP) combined with 40 mg/kg/dose s.c. desferrioxamine (DFO) twice weekly) | Decreases - exhibited a significant fall | median ferritin levels | Human | responders (among transfusion-dependent β-thalassemia children) | 50-100 mg/kg/day oral DFP combined with 40 mg/kg/dose s.c. DFO twice weekly. | Combined chelation therapy with daily oral deferiprone and twice-weekly subcutaneous infusion of desferrioxamine in children with β-thalassemia: 3-year experience.cited 15× |
| combined treatment with oral and subcutaneous iron chelators (50-100 mg/kg/day of oral deferiprone (DFP) combined with 40 mg/kg/dose s.c. desferrioxamine (DFO) twice weekly) | Decreases - Time to a significant decrease | serum ferritin | Human | responders (among transfusion-dependent β-thalassemia children) | 50-100 mg/kg/day oral DFP combined with 40 mg/kg/dose s.c. DFO twice weekly. | Combined chelation therapy with daily oral deferiprone and twice-weekly subcutaneous infusion of desferrioxamine in children with β-thalassemia: 3-year experience.cited 15× |
| iron polymaltose (IPM) supplementation | No effect - failed to increased | ferritin concentrations | Human | schoolchildren aged 5-18 years with mild or moderate anaemia | 6 mg elemental iron/kg/day | Effect of a short course of iron polymaltose on acquisition of malarial parasitaemia in anaemic Indonesian schoolchildren: a randomized trial.cited 4× |
| iron supplement | Increases - increased | serum ferritin level | Human | 3- to 6-y old preschoolers | Single oral dose of vitamin A (retinol 200,000 IU) | No enhancing effect of vitamin A administration on iron absorption or body total iron content in preschool children from Chengdu, China.cited 8× |
| IV iron | Increases - significantly increased | ferritin | Human | patients with CKD | Not specified | Parenteral versus oral iron therapy for adults and children with chronic kidney disease.cited 82× |
| IV iron | Increases - increased | ferritin | Human | adults and children with CKD | Not specified in the abstract. | Parenteral versus oral iron therapy for adults and children with chronic kidney disease.cited 43× |
| Sucrosomial iron | Increases - showed significantly higher improvement | serum ferritin levels | Human | subjects with hemoglobin between 7-10 g/dl | Not specified in the abstract. | Comparative evaluation of different oral iron salts in the management of iron deficiency anemia. |
| community-based weekly iron-folic acid supplementation (WIFAS) | Increases - increased | serum ferritin (SF) | Human | adolescent girls | Weekly iron-folic acid supplementation (specific dosage not mentioned in the abstract). | A community-based randomized controlled trial providing weekly iron-folic acid supplementation increased serum- ferritin, -folate and hemoglobin concentration of adolescent girls in southern Ethiopia.cited 12× |
| community-based weekly iron-folic acid supplementation (WIFAS) | Increases - was associated with an improvement of | serum ferritin | Human | adolescent girls | Weekly iron-folic acid supplementation (specific dosage not mentioned in the abstract). | A community-based randomized controlled trial providing weekly iron-folic acid supplementation increased serum- ferritin, -folate and hemoglobin concentration of adolescent girls in southern Ethiopia.cited 12× |
| >Your< Iron Syrup | Increases - resulted in a significant increase | ferritin levels | Human | healthy children with iron deficiency | Not available | Micronized, Microencapsulated Ferric Iron Supplementation in the Form of >Your< Iron Syrup Improves Hemoglobin and Ferritin Levels in Iron-Deficient Children: Double-Blind, Randomized Clinical Study of Efficacy and Safety.cited 3× |
| daily supplements of 10 mg of iron and 0.5 mg of copper with or without 10 mg of zinc | Decreases - decreased | plasma ferritin | Human | non-anemic Peruvian infants | 0.5 mg of copper daily. | Mineral status of non-anemic Peruvian infants taking an iron and copper syrup with or without zinc from 6 to 18 months of age: a randomized controlled trial.cited 8× |
| delayed iron supplementation | Decreases - reflected poorer iron status | ferritin | Human | children aged 6-59 mo with malaria and hemoglobin concentrations of 50.0-99.9 g/L | Not specified in the abstract. | Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial.cited 17× |
| delayed iron supplementation | No effect - did not differ | plasma ferritin | Human | children aged 6-59 mo with malaria and hemoglobin concentrations of 50.0-99.9 g/L | Not specified in the abstract. | Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial.cited 17× |