Liposomal ferric pyrophosphate and ascorbic acid supplementation in pregnant women with iron deficiency anaemia: haematochemical, obstetric, neonatal and psychological outcomes in a prospective observational study.
Study Goal
The researchers aimed to determine the effects of liposomal iron pyrophosphate/ascorbic acid (Sideremil™) on clinical and psychological outcomes in pregnant women with iron deficiency anaemia.
Results Summary
The study found significant positive effects on haemoglobin, ferritin, sideremia, and transferrin levels, as well as improvements in anxiety, depression, and quality of life, particularly in the Physical Role domain.
Population
Pregnant women at 11th-13th weeks of gestation with iron deficiency anaemia.
Effective Dosage
Not specified
Duration
From 11th-13th weeks of gestation to 6 weeks postpartum
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
liposomal iron pyrophosphate/ascorbic acid | increase | haemoglobin levels | pregnant women with iron deficiency anaemia | - | significant positive effects | #1 |
liposomal iron pyrophosphate/ascorbic acid | increase | ferritin levels | pregnant women with iron deficiency anaemia | - | significant positive effects | #2 |
liposomal iron pyrophosphate/ascorbic acid | increase | sideremia levels | pregnant women with iron deficiency anaemia | - | significant positive effects | #3 |
liposomal iron pyrophosphate/ascorbic acid | increase | transferrin levels | pregnant women with iron deficiency anaemia | - | significant positive effects | #4 |
liposomal iron pyrophosphate/ascorbic acid | decrease | anxiety levels | pregnant women with iron deficiency anaemia | - | significant improvement | #5 |
liposomal iron pyrophosphate/ascorbic acid | decrease | depression levels | pregnant women with iron deficiency anaemia | - | significant improvement | #6 |
liposomal iron pyrophosphate/ascorbic acid | increase | quality of life domains | pregnant women with iron deficiency anaemia | - | significantly improved | #7 |
liposomal iron pyrophosphate/ascorbic acid | increase | Physical Role domain of quality of life | pregnant women with iron deficiency anaemia | - | significantly improved | #8 |
This study aimed to determine the effects of liposomal iron pyrophosphate/ascorbic acid on clinical and psychological outcomes in pregnant women. Women at the 11th-13th weeks of gestation with iron deficiency anaemia assuming Sideremil™ from April 2018 to May 2019 were recruited. Haematochemical, obstetric, neonatal and psychological outcomes were investigated at the enrolment, 21-23 weeks of gestation, 30-32 weeks of gestation and after 6 weeks from childbirth. Results showed significant positive effects on haemoglobin, ferritin, sideremia and transferrin levels, compared to baseline data. A significant improvement of anxiety and depression levels was also observed. Regarding the quality of life, all the domains significantly improved, especially the Physical Role domain. Our results indicate that Sideremil