Iron supplementation in singleton pregnancy: Is there a benefit to doubling the dose of elemental iron in iron-deficient pregnant women? a randomized controlled trial.
Study Goal
To determine whether doubling the standard 30 mg dose of iron is more effective than a single dose in treating iron deficiency anemia in pregnant women.
Results Summary
The study found no significant difference in hemoglobin levels between women receiving one or two capsules of iron, suggesting that a single dose is as effective as a double dose. Secondary outcomes, including ferritin levels, birth weights, and preterm birth rates, were also similar between groups.
Population
Iron-deficient women with singleton pregnancies in their second trimester.
Effective Dosage
34 mg ferrous sulfate (one or two capsules daily).
Duration
From 17 weeks of pregnancy until 6 weeks postpartum.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
one capsule of daily iron supplement, containing 34 mg of ferrous sulfate | no change | Hgb at 35 weeks | iron-deficient women in singleton pregnancies | - | had similar | #1 |
two capsules of daily iron supplement, containing 34 mg of ferrous sulfate | no change | Hgb at 35 weeks | iron-deficient women in singleton pregnancies | - | had similar | #2 |
one capsule of daily iron supplement, containing 34 mg of ferrous sulfate | no change | ferritin at 35 weeks | iron-deficient women in singleton pregnancies | - | had similar | #3 |
two capsules of daily iron supplement, containing 34 mg of ferrous sulfate | no change | ferritin at 35 weeks | iron-deficient women in singleton pregnancies | - | had similar | #4 |
one capsule of daily iron supplement, containing 34 mg of ferrous sulfate | no change | Hgb during pregnancy and postpartum | iron-deficient women in singleton pregnancies | - | had similar | #5 |
two capsules of daily iron supplement, containing 34 mg of ferrous sulfate | no change | Hgb during pregnancy and postpartum | iron-deficient women in singleton pregnancies | - | had similar | #6 |
one capsule of daily iron supplement, containing 34 mg of ferrous sulfate | no change | birth weights | iron-deficient women in singleton pregnancies | - | had similar | #7 |
two capsules of daily iron supplement, containing 34 mg of ferrous sulfate | no change | birth weights | iron-deficient women in singleton pregnancies | - | had similar | #8 |
one capsule of daily iron supplement, containing 34 mg of ferrous sulfate | no change | preterm birth rate | iron-deficient women in singleton pregnancies | - | had similar | #9 |
two capsules of daily iron supplement, containing 34 mg of ferrous sulfate | no change | preterm birth rate | iron-deficient women in singleton pregnancies | - | had similar | #10 |
one capsule of daily iron supplement, containing 34 mg of ferrous sulfate | no change | gastrointestinal side effects | iron-deficient women in singleton pregnancies | - | had similar | #11 |
two capsules of daily iron supplement, containing 34 mg of ferrous sulfate | no change | gastrointestinal side effects | iron-deficient women in singleton pregnancies | - | had similar | #12 |
one capsule of daily iron supplement, containing 34 mg of ferrous sulfate | no change | intravenous iron administration | iron-deficient women in singleton pregnancies | - | had similar | #13 |
two capsules of daily iron supplement, containing 34 mg of ferrous sulfate | no change | intravenous iron administration | iron-deficient women in singleton pregnancies | - | had similar | #14 |
one capsule of daily iron supplement, containing 34 mg of ferrous sulfate | no change | compliance | iron-deficient women in singleton pregnancies | - | had similar | #15 |
two capsules of daily iron supplement, containing 34 mg of ferrous sulfate | no change | compliance | iron-deficient women in singleton pregnancies | - | had similar | #16 |
OBJECTIVE: To assess the efficacy of doubling the 30 mg dose of iron in women with iron deficiency anemia (IDA) in singleton pregnancies. STUDY DESIGN: Prospective randomized controlled trial. Iron-deficient women were randomized during the second trimester to receive one or two capsules of daily iron supplement, containing 34 mg of ferrous sulfate, from 17 weeks until 6 weeks postpartum. The primary outcome was hemoglobin (Hgb) at 35 weeks. Secondary outcomes included ferritin at 35 weeks, Hgb during pregnancy and postpartum, birth weights, preterm birth rate, gastrointestinal side effects, intravenous iron administration and compliance. RESULTS: In all, 160 women were randomized to receive one capsule and 164 received two capsules. Both groups had similar Hgb (10.1 g dl CONCLUSION: In IDA pregnant women, a single dose of iron is as effective as a double dose.