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Is every other day iron supplementation effective for the treatment of the iron deficiency anemia in pregnancy?

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
March 1, 2022
Gokhan Karakoc et al. (4 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Study Details

Study Goal

To compare the effectiveness of every other day iron supplementation versus daily intake for treating iron deficiency anemia in pregnant women.

Results Summary

Ferritin levels increased in both groups, with a slightly higher increase in the daily intake group (4.9 ng/mL) compared to the every other day group (3.9 ng/mL). Every other day supplementation was found to be as effective as daily intake with fewer gastrointestinal side effects.

Population

Anemic pregnant women at a tertiary hospital in Turkey.

Effective Dosage

Not specified in the abstract.

Duration

Not specified in the abstract.

Interactions

None mentioned.

Extracted Claims (4)
InterventionDirectionEndpointPopulationDosageImpactClaim #
every other day iron supplementation
no change
treating iron deficiency anemia
anemic pregnant women
-
is as effective as daily intake
#1
daily iron intake
increase
ferritin levels
anemic pregnant women
4.9 ± 4.2 ng/mL
increased
#2
every other day iron supplementation
increase
ferritin levels
anemic pregnant women
3.9 ± 2.9 ng/mL
increased
#3
every other day iron supplementation
decrease
gastrointestinal side effects
anemic pregnant women
-
lesser
#4
Abstract

AIM: To understand if every other day iron supplementation may be as effective as daily iron intake in anemic pregnant women. METHODS: This case-control study was conducted at a tertiary hospital in Turkey. The study randomly categorized women into two groups as daily intake ( RESULTS: The ferritin levels increased 4.9 ± 4.2 ng/mL in the daily intake group and 3.9 ± 2.9 ng/mL in every other day group ( CONCLUSION: Every other day iron supplementation is as effective as daily intake for treating iron deficiency anemia with lesser gastrointestinal side effects during pregnancy.

Medical Subject Headings (MeSH)
AnemiaAnemia, Iron-DeficiencyCase-Control StudiesDietary SupplementsFemaleHemoglobinsHumansIronIron DeficienciesPregnancyPregnancy Complications, Hematologic
Study Links
Quality Scores
Safety80
Efficacy85/10
Quality75/10
Citation Metrics
Total Citations6
Citations/Year2.0
Relative Citation Ratio1.18
NIH Percentile56.5%
Research Impact Scores
APT Score0.50
Weight Score2.45
Normalized Score0.81
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