SAFETY AND EFFICACY OF INTRAVENOUS ADMINISTRATION OF IRON PREPARATIONS.
Study Goal
The researchers aimed to evaluate the characteristics, benefits, and risks of intravenous iron preparations, particularly focusing on high single-dose administration in various clinical situations.
Results Summary
Iron supplementation, both oral and intravenous, effectively increases hemoglobin levels and reduces anemia symptoms. Intravenous iron is particularly beneficial for patients with impaired gastrointestinal absorption, large deficits, or poor tolerance to oral formulations.
Population
Patients with iron deficiency anemia, including those with impaired iron absorption or poor tolerance to oral iron.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Iron supplementation | increase | transferrin saturation | - | - | leads to a rise | #1 |
Iron supplementation | increase | ferritin concentration | - | - | leads to a rise | #2 |
Iron supplementation | increase | hemoglobin level | - | - | resulting in an increased | #3 |
Iron supplementation | decrease | anemia symptoms | - | - | decrease | #4 |
Oral iron administration | neutral | iron deficiency anemia | - | - | is a treatment of choice | #5 |
intravenous iron | neutral | - | patients with impaired iron absorption from the gastrointestinal tract | - | becomes necessary to apply | #6 |
intravenous iron | neutral | - | patients with large deficits | - | becomes necessary to apply | #7 |
intravenous iron | neutral | - | patients with poor tolerance of oral formulations | - | becomes necessary to apply | #8 |
Iron deficiency is the main cause of anemia worldwide. Iron supplementation leads to a rise of transferrin saturation and ferritin concentration, resulting in an increased hemoglobin level and decrease of anemia symptoms. Oral iron administration is a treatment of choice in iron deficiency anemia. In patients with impaired iron absorption from the gastrointestinal tract, as well as in large deficits, or poor tolerance of oral formulations, it becomes necessary to apply iron intravenously. In this paper we present, on the basis of current publications, the characteristics of intravenous iron preparations nowadays available on the market, in various clinical situations, with particular focus on their benefits and risk related to the administration of high single iron doses.