Amino Acid Chelated Iron Versus Ferric Ammonium Citrate on Iron Status in Egyptian Children with Iron Deficiency Anemia: A Randomized Controlled Study.
Study Goal
The researchers aimed to compare the effectiveness of iron amino acid chelated (AACI) preparation versus ferric ammonium citrate (FAC) in treating iron deficiency anemia in school-age children.
Results Summary
The study found that both AACI and FAC improved iron status indices, with AACI showing greater improvements in hemoglobin, MCV, serum iron, and serum ferritin levels, though the difference between the two treatments was not statistically significant.
Population
160 children aged 5-13 years with iron deficiency anemia.
Effective Dosage
Once daily at bedtime (specific dosage not provided).
Duration
8 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
iron amino acid chelated (AACI) preparation | increase | Hb | school-age children with iron deficiency anemia | from 9.9 ± 1.1 to 11.5 ± 0.3 gm/l | had increase in | #1 |
iron amino acid chelated (AACI) preparation | increase | MCV(fl) | school-age children with iron deficiency anemia | from 63.57.7 ± to 69 ± 6.3 | had increase in | #2 |
iron amino acid chelated (AACI) preparation | increase | serum iron | school-age children with iron deficiency anemia | from 49.5 ± 5.8 to 87 ± 12.7 ug/dl | had increase in | #3 |
iron amino acid chelated (AACI) preparation | increase | serum ferritin | school-age children with iron deficiency anemia | from 26.2 ± 10.5 to 116.4 ± 19.7 ng/ml | had increase in | #4 |
ferric ammonium citrate (FAC) | increase | HB | school-age children with iron deficiency anemia | from 10.1 ± 1.7 to 11.2 ± 0.8 | there was increase in | #5 |
ferric ammonium citrate (FAC) | increase | MCV | school-age children with iron deficiency anemia | from 64.5 ± 8.02 to 73.2 ± 8.9 | there was increase in | #6 |
ferric ammonium citrate (FAC) | increase | serum iron | school-age children with iron deficiency anemia | from 48.2 ± 3.5 to 74.3 ± 15 ug/dl | there was increase in | #7 |
ferric ammonium citrate (FAC) | increase | serum ferritin | school-age children with iron deficiency anemia | from 28.1 ± 9.3 to 84.3 ± 15.2 ng/ml | there was increase in | #8 |
iron amino acid chelated (AACI) preparation | increase | iron status indices | school-age children with iron deficiency anemia | - | showed much improvement in | #9 |
iron amino acid chelated (AACI) preparation | no change | iron status indices | school-age children with iron deficiency anemia | - | no significant statistically difference between it and | #10 |
UNLABELLED: Few studies have compared the relative effectiveness of different iron compounds on iron status in school-age children with iron deficiency anemia. The objective of this study was to compare the effect of iron amino acid chelated (AACI) preparation versus ferric ammonium citrate (FAC) in treatment of iron deficiency anemia. PATIENTS AND METHODS: A randomized, clinical study was conducted on one hundred and sixty children aged 5-13 years old proved to have iron deficiency according to guide lines of WHO, 2001. All included children were subjected to the following laboratory investigations: CBC, reticulocytic count, CRP, serum iron, total iron binding capacity (TIBC), serum ferritin (SF), and serum hepcidin. Patients were assigned to two treatment regimens on randomized base 1:1 either to supplement with (AACI) or (FAC) once daily at bedtime. The subjects were followed up for eight weeks. RESULTS: At the end of the study, group 1 who received AACI had increase in: Hb from 9.9 ± 1.1to 11.5 ± 0.3 gm/l(p = 0.01), MCV(fl) from 63.57.7 ± to 69 ± 6.3 (p = 0.05), serum iron from 49.5 ± 5.8 to 87 ± 12.7ug/dl(p = 0.001), serum ferritin from26.2 ± 10.5to 116.4 ± 19.7ng/ml(p = 0.001) while in group 2 who received FAC, there was increase in: HB from10.1 ± 1.7 to 11.2 ± 0.8, (p = 0.1), MCV from 64.5 ± 8.02 to 73.2 ± 8.9 (p = 0.01), serum iron from 48.2 ± 3.5to74 .3 ± 15 ug/dl (p = 0.01) and serum ferritin from 28.1 ± 9.3 to 84.3 ± 15.2 ng/ml (p = 0.006). CONCLUSION: Our study showed much improvement in iron status indices in AACI preparation with no significant statistically difference between it and FAC.