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The Use of Parenteral Iron Therapy for the Treatment of Postpartum Anemia.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
May 1, 2015
Christopher M Nash et al. (2 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the effectiveness and tolerability of parenteral iron compared to oral iron for treating postpartum anemia.

Results Summary

Parenteral iron was associated with faster increases in serum ferritin and hemoglobin levels, improved maternal fatigue scores, and potentially reduced blood transfusion rates compared to oral iron. It was also noted as a better-tolerated treatment modality.

Population

Postpartum women with anemia in Canada.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (4)
InterventionDirectionEndpointPopulationDosageImpactClaim #
parenteral iron
increase
serum ferritin
postpartum period
more rapid
associated with a more rapid rise
#1
parenteral iron
increase
hemoglobin
postpartum period
more rapid
associated with a more rapid rise
#2
parenteral iron
increase
maternal fatigue scores
postpartum period
-
improved
#3
parenteral iron
decrease
rates of blood transfusion
-
-
may also decrease
#4
Abstract

Rates of postpartum hemorrhage have been increasing in Canada over the last 10 years, with postpartum iron deficiency anemia as the most common consequence. Postpartum anemia is treated with oral iron supplementation and/or blood transfusion. Recent studies have evaluated the use of parenteral iron as a better tolerated treatment modality. Compared with oral iron supplements, parenteral iron is associated with a more rapid rise in serum ferritin and hemoglobin and improved maternal fatigue scores in the postpartum period. It may also decrease rates of blood transfusion. Parenteral iron may be considered in select clinical situations for the treatment of postpartum anemia. Les taux d’hémorragie postpartum ont connu une hausse au Canada depuis les 10 dernières années, la manifestation d’une anémie ferriprive postpartum en étant la conséquence la plus courante. L’anémie postpartum est prise en charge au moyen d’une supplémentation orale en fer et/ou d’une transfusion sanguine. De récentes études ayant évalué l’utilisation de fer parentéral ont indiqué qu’il s’agissait d’une modalité de traitement mieux tolérée. Par comparaison avec les suppléments oraux de fer, le fer parentéral est associé à une hausse plus rapide des taux sériques de ferritine et d’hémoglobine, en plus de mener à une amélioration des scores de fatigue maternelle au cours de la période postpartum. Le fer parentéral pourrait également mener à une diminution des taux de transfusion sanguine. Son utilisation pourrait être envisagée dans certaines situations cliniques particulières, aux fins de la prise en charge de l’anémie postpartum.

Medical Subject Headings (MeSH)
Anemia, Iron-DeficiencyFemaleFerric CompoundsFerric Oxide, SaccharatedGlucaric AcidHematinicsHumansInfusions, ParenteralIron-Dextran ComplexPuerperal Disorders
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality75/10
Citation Metrics
Total Citations10
Citations/Year1.0
Relative Citation Ratio0.53
NIH Percentile28.8%
Research Impact Scores
APT Score0.50
Weight Score1.59
Normalized Score0.69
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