Is Iron Supplementation Influenced by Sub-Clinical Inflammation?: A Randomized Controlled Trial Among Adolescent Schoolgirls in Myanmar.
Study Goal
The researchers aimed to determine the influence of sub-clinical inflammation on iron supplementation and whether vitamin A improved the efficacy of iron supplementation in the presence of sub-clinical inflammation.
Results Summary
The study found that vitamin A improved hemoglobin changes and the efficacy of iron supplementation in the presence of sub-clinical inflammation. Those treated with vitamin A had better outcomes when inflammation was present.
Population
Anaemic adolescent schoolgirls in the Ayeyarwady region, Myanmar.
Effective Dosage
15,000 IU of vitamin A once a week.
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Iron supplementation | decrease | iron absorption | those with sub-clinical inflammation | - | might hamper the effect | #1 |
Iron folate group (60 mg elemental iron and folate) | increase | changes in serum ferritin and body iron | anaemic adolescent schoolgirls without sub-clinical inflammation | - | significantly higher | #2 |
Iron, vitamin A and folate group | increase | changes in serum ferritin and body iron | anaemic adolescent schoolgirls without sub-clinical inflammation | - | significantly higher | #3 |
Vitamin A | neutral | hemoglobin changes | anaemic adolescent schoolgirls | - | interaction with SCI on Hb changes | #4 |
treatment | neutral | hemoglobin | anaemic adolescent schoolgirls | - | interactions with SCI | #5 |
treatment | neutral | serum transferrin receptor | anaemic adolescent schoolgirls | - | interactions with SCI | #6 |
Vitamin A | increase | iron supplementation efficacy | anaemic adolescent schoolgirls with sub-clinical inflammation | - | had better outcomes | #7 |
Inflammation | decrease | iron supplementation efficacy | anaemic adolescent schoolgirls | - | accompanied a negative effect | #8 |
Vitamin A | increase | iron supplementation | anaemic adolescent schoolgirls in the presence of sub-clinical inflammation | - | improved efficacy | #9 |
Iron absorption was impaired in the presence of sub-clinical inflammation (SCI) and might hamper the effect of iron supplementation. The purpose of the study was to identify the influence of SCI on iron supplementation. A randomized, double-blinded, placebo-controlled experimental study was conducted among anaemic adolescent schoolgirls in Ayeyarwady region, Myanmar. A total of 402 schoolgirls were recruited from six schools screened from 1269 girls who were assigned into one of four groups: Folate group (2.5 mg of folate), Vitamin A group (15,000 IU of vitamin), Iron folate group (60 mg elemental iron and folate) and Iron, and vitamin A and folate group. Supplementation was done once a week for 12 weeks. Iron, vitamin A and inflammation were measured at the baseline, middle and endline. Changes in serum ferritin and body iron were significantly higher in the IFA and IFA + vitA among those without SCI. There was interaction between vitamin A and SCI on Hb changes. Analysis of GLM repeated measure showed interactions between treatment and SCI for hemoglobin and serum transferrin receptor. Those treated with vitamin A had better outcomes when there was SCI. Inflammation accompanied a negative effect on iron supplementation and vitamin A improved efficacy of iron supplementation in the presence of SCI.