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The interplay between maternal-infant anemia and iron deficiency.

Nutrition reviews
January 1, 1970
Eliza M Davidson et al. (3 authors)
ReviewJournal ArticleResearch Support, Non-U.S. Gov'tHuman Study
Study Details

Study Goal

The researchers aimed to determine the impact of maternal iron deficiency anemia during pregnancy on infant hemoglobin and iron stores in the first year of life, and whether iron supplementation could mitigate these effects.

Results Summary

Severe maternal iron deficiency anemia in pregnancy was associated with lower infant ferritin and hemoglobin levels at birth, and increased risk of iron deficiency and anemia in infants aged 6-12 months. Iron supplementation during pregnancy may reduce infant anemia risk, but more evidence is needed to confirm its functional impact.

Population

Pregnant women and their infants up to 12 months of age.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (6)
InterventionDirectionEndpointPopulationDosageImpactClaim #
severe maternal iron deficiency anemia in pregnancy
decrease
ferritin levels
infants at birth
-
is associated with lower
#1
severe maternal iron deficiency anemia in pregnancy
decrease
hemoglobin levels
infants at birth
-
is associated with lower
#2
severe anemia in pregnancy
increase
iron deficiency
infants 6-12 months of age
-
increases the risk of
#3
severe anemia in pregnancy
increase
anemia
infants 6-12 months of age
-
increases the risk of
#4
iron supplementation
decrease
infant anemia
infants during the first year of life
-
could reduce the risk of
#5
iron supplementation
decrease
iron deficiency
infants during the first year of life
-
could reduce the risk of
#6
Abstract

Iron deficiency anemia in pregnancy is a major public health problem known to cause maternal morbidity and adverse birth outcomes, and it may also have lasting consequences on infant development. However, the impact of the maternal hematological environment on fetal and infant hemoglobin and iron stores in the first year of life remains unclear. This review of the epidemiological evidence found that severe maternal iron deficiency anemia in pregnancy is associated with lower ferritin, and to a lesser degree hemoglobin levels, in infants at birth. Emerging data also suggests that severe anemia in pregnancy increases the risk of iron deficiency and anemia in infants 6-12 months of age, although longitudinal studies are limited. Effective anemia prevention in pregnancy, such as iron supplementation, could reduce the risk of infant anemia and iron deficiency during the first year of life; however, more evidence is needed to determine the functional impact of iron supplementation in pregnancy on infant hematological indices.

Medical Subject Headings (MeSH)
PregnancyInfant, NewbornFemaleChildInfantHumansAnemia, Iron-DeficiencyIron DeficienciesIronAnemiaHemoglobins
Study Links
Quality Scores
SafetyNot Assessed
Efficacy70/10
Quality75/10
Citation Metrics
Total Citations11
Citations/Year5.5
Relative Citation Ratio2.71
NIH Percentile82.7%
Research Impact Scores
APT Score0.75
Weight Score1.60
Normalized Score0.63
Related Supplements
The interplay between maternal-infant anemia and iron defici... | Panacea Index