173
16
45
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Evidence suggests Iron mayincreaseHemoglobin levels.
152 studies (234 claims)
Moderate consensus
Typical effective dose 60 (27.5–200) mgacross 39 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| intravenous iron sucrose alone | Increases - increase from baseline of 3.7 g/dL | hemoglobin level | Human | women with postpartum hemoglobin level of ≤9.5 g/dL | 500 mg intravenous iron sucrose (single dose) and 60 mg oral iron bisglycinate daily for 45 days (for the combined group). | Addition of oral iron bisglycinate to intravenous iron sucrose for the treatment of postpartum anemia-randomized controlled trial.cited 4× |
| intravenous iron sucrose in combination with oral iron bisglycinate supplementation | Increases - postpartum hemoglobin levels were only 0.4 g/dL higher | hemoglobin level | Human | women with postpartum hemoglobin level of ≤9.5 g/dL | 500 mg intravenous iron sucrose (single dose) and 60 mg oral iron bisglycinate daily for 45 days (for the combined group). | Addition of oral iron bisglycinate to intravenous iron sucrose for the treatment of postpartum anemia-randomized controlled trial.cited 4× |
| intravenous iron sucrose in combination with oral iron bisglycinate supplementation | Increases - increase from baseline of 4.2 g/dL | hemoglobin level | Human | women with postpartum hemoglobin level of ≤9.5 g/dL | 500 mg intravenous iron sucrose (single dose) and 60 mg oral iron bisglycinate daily for 45 days (for the combined group). | Addition of oral iron bisglycinate to intravenous iron sucrose for the treatment of postpartum anemia-randomized controlled trial.cited 4× |
| oral iron bisglycinate supplementation | No effect - was no difference in the rate of women with hemoglobin level of <12.0 or 11.0 g/dL | rate of women with hemoglobin level of <12.0 or 11.0 g/dL | Human | women with postpartum hemoglobin level of ≤9.5 g/dL | 500 mg intravenous iron sucrose (single dose) and 60 mg oral iron bisglycinate daily for 45 days (for the combined group). | Addition of oral iron bisglycinate to intravenous iron sucrose for the treatment of postpartum anemia-randomized controlled trial.cited 4× |
| daily supplement of 30 mg/day of elemental iron as ferrous sulfate | No effect - did not change significantly | hemoglobin concentration | Human | schoolchildren with low iron stores as assessed by serum ferritin concentration but without anemia | 30 mg/day of elemental iron | Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial.cited 32× |
| daily supplement of 30 mg/day of elemental iron as iron bis-glycinate chelate | No effect - did not change significantly | hemoglobin concentration | Human | schoolchildren with low iron stores as assessed by serum ferritin concentration but without anemia | 30 mg/day of elemental iron | Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial.cited 32× |
| iron deficiency anemia | No effect - should arouse suspicion of | low hemoglobin and a peripheral blood film showing hypochromia, microcytosis, and marked anisocytosis | Human | — | 3 to 6 mg/kg of elemental iron per day (for treatment, not dietary counseling specifically). | Iron Deficiency Anemia: An Updated Review.cited 24× |
| iron-folic acid supplementation | Increases - increases | hemoglobin | Human | pregnant women | Not specified | Maternal iron-folic acid supplementation programs: evidence of impact and implementation.cited 78× |
| iron-folic acid supplementation | Increases - increases | hemoglobin | Human | pregnant women in developed countries | Not specified | Maternal iron-folic acid supplementation programs: evidence of impact and implementation.cited 78× |
| iron-folic acid supplementation | Increases - increases | hemoglobin | Human | pregnant women in developing countries | Not specified | Maternal iron-folic acid supplementation programs: evidence of impact and implementation.cited 78× |
| iron-folic acid (IFA) supplementation | Increases - can significantly improve | serum hemoglobin concentration | Human | adolescents | Not available | Systematic review on evidence-based adolescent nutrition interventions.cited 65× |
| iron supplementation | Increases - can significantly improve | serum hemoglobin concentration | Human | adolescents | Not available | Systematic review on evidence-based adolescent nutrition interventions.cited 65× |
| simple iron supplementation strategies | Increases - demonstrated the feasibility of | a 1-g/dL increase in hemoglobin (Hb) | Human | — | Not specified | The impact of anemia on child mortality: an updated review.cited 119× |
| polymaltose iron (FeP) | Increases - resulted in significant increases | hemoglobin levels | Human | anemic children aged 1 to 13 years diagnosed with IDA | 3.0 mg iron/kg body weight/day for both FeBC and FeP. | Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial.cited 11× |
| iron bisglycinate chelate (FeBC) | Increases - resulted in significant increases | hemoglobin levels | Human | anemic children aged 1 to 13 years diagnosed with IDA | 3.0 mg iron/kg body weight/day for both FeBC and FeP. | Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial.cited 11× |
| iron bisglycinate chelate (FeBC) | Increases - significantly increased | Mean Corpuscular Hemoglobin (MCH) levels | Human | anemic children aged 1 to 13 years diagnosed with IDA | 3.0 mg iron/kg body weight/day for both FeBC and FeP. | Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial.cited 11× |
| double dose of daily iron | Increases - was significantly higher | Hemoglobin | Human | iron-deficient women with twin gestations | 34 mg of ferrous sulfate (single or double dose daily). | Iron Supplementation in Twin Pregnancy - The Benefit of Doubling the Iron Dose in Iron Deficient Pregnant Women: A Randomized Controlled Trial.cited 5× |
| double dose of daily iron | No effect - no significant differences | hemoglobin during pregnancy and postpartum | Human | iron-deficient women with twin gestations | 34 mg of ferrous sulfate (single or double dose daily). | Iron Supplementation in Twin Pregnancy - The Benefit of Doubling the Iron Dose in Iron Deficient Pregnant Women: A Randomized Controlled Trial.cited 5× |
| doubling the daily dose of iron supplement | Increases - increases | hemoglobin | Human | iron-deficient women with twin pregnancies | 34 mg of ferrous sulfate (single or double dose daily). | Iron Supplementation in Twin Pregnancy - The Benefit of Doubling the Iron Dose in Iron Deficient Pregnant Women: A Randomized Controlled Trial.cited 5× |
| iron-biofortified beans (Fe-Beans) | Increases - significantly greater increases in | hemoglobin | Human | Rwandan women | Fe-Beans (86 mg Fe/kg) or Control-Beans (50 mg Fe/kg), consumed twice daily. | Consuming Iron Biofortified Beans Increases Iron Status in Rwandan Women after 128 Days in a Randomized Controlled Feeding Trial.cited 86× |
| iron-biofortified beans | Increases - significant improvements | hemoglobin | Human | 55 women aged 18-27 y with low iron status (serum ferritin <20 µg/L) | Daily consumption of iron-biofortified beans (86.1 ppm iron) vs. comparison beans (50.1 ppm iron). | Changes in Iron Status Are Related to Changes in Brain Activity and Behavior in Rwandan Female University Students: Results from a Randomized Controlled Efficacy Trial Involving Iron-Biofortified Beans.cited 21× |
| community-led initiative for once-weekly iron supplementation for adolescent girls and iron prophylaxis for children, in addition to nutritional education | Increases - improved | hemoglobin status | Human | children 6 to 35 months of age and unmarried rural adolescent girls 12 to 19 years of age | Weekly iron-folic acid tablets for adolescent girls; daily liquid iron prophylaxis for children for 100 days/year. | Community-led initiative for control of anemia among children 6 to 35 months of age and unmarried adolescent girls in rural Wardha, India.cited 27× |
| intermittent administration (IA) of intravenous iron | No effect - has similar effects | mean levels of hemoglobin (Hb) | Human | maintenance hemodialysis (MHD) patients | 100 mg sucrose iron agents per session (continuous: every HD session; intermittent: once weekly), totaling 1000 mg. | Effect of frequency of intravenous iron administration on hemoglobin variability in maintenance hemodialysis patients.cited 5× |
| continuous administration (CA) of intravenous iron | No effect - has similar effects | mean levels of hemoglobin (Hb) | Human | maintenance hemodialysis (MHD) patients | 100 mg sucrose iron agents per session (continuous: every HD session; intermittent: once weekly), totaling 1000 mg. | Effect of frequency of intravenous iron administration on hemoglobin variability in maintenance hemodialysis patients.cited 5× |
| iron supplementation, either oral or intravenous | Increases - optimization | preoperative hemoglobin | Human | patient with anemia | Not specified | Erythropoietin and intravenous iron in PBM.cited 7× |
| directly observed iron-folic acid (IFA) supplementation | Increases - increase in the mean hemoglobin level over and above control group was 0.52 g/dl | mean hemoglobin level | Human | pregnant women in a rural setting of north India | Not specified in the abstract. | Effect of directly observed oral iron supplementation during pregnancy on iron status in a rural population in Haryana: A randomized controlled trial.cited 13× |
| iron amino acid chelate (IAAC) | Increases - rise in hemoglobin level was significantly faster | hemoglobin level | Human | pregnant women having iron deficiency anemia (IDA) | Not specified | Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study.cited 15× |
| postoperative oral iron supplementation | No effect - improves | hemoglobin levels | Human | elective TJA patients | Not specified | Intraoperative and Postoperative Iron Supplementation in Elective Total Joint Arthroplasty: A Systematic Review.cited 2× |
| postoperative oral iron supplementation | No effect - had no effect on | postoperative hemoglobin levels | Human | elective TJA patients | Not specified | Intraoperative and Postoperative Iron Supplementation in Elective Total Joint Arthroplasty: A Systematic Review.cited 2× |
| intraoperative and postoperative intravenous iron supplementation | Increases - was associated with greater increases in | hemoglobin levels | Human | elective TJA patients | Not specified | Intraoperative and Postoperative Iron Supplementation in Elective Total Joint Arthroplasty: A Systematic Review.cited 2× |
| intraoperative and postoperative intravenous iron supplementation | Increases - may accelerate recovery of | hemoglobin levels | Human | elective TJA patients | Not specified | Intraoperative and Postoperative Iron Supplementation in Elective Total Joint Arthroplasty: A Systematic Review.cited 2× |
| intraoperative and postoperative intravenous iron supplementation | Increases - was associated with higher | postoperative hemoglobin levels | Human | elective TJA patients | Not specified | Intraoperative and Postoperative Iron Supplementation in Elective Total Joint Arthroplasty: A Systematic Review.cited 2× |
| oral supplementation in iron-deficiency anemia | Increases - should be administered with a target to restore/replenish | iron stores and the hemoglobin level | Human | — | Not specified | Management of Iron-Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review.cited 57× |
| oral iron supplementation (one tablet of ferrous gluconate (37.5 mg of elemental iron) daily) | Decreases - shortened time to 80% hemoglobin recovery | time to recovery of 80% of the postdonation decrease in hemoglobin | Human | blood donors with low ferritin (≤26 ng/mL) | 37.5 mg elemental iron (as ferrous gluconate) daily. | Oral iron supplementation after blood donation: a randomized clinical trial.cited 120× |
| oral iron supplementation (one tablet of ferrous gluconate (37.5 mg of elemental iron) daily) | Decreases - shortened time to 80% hemoglobin recovery | time to recovery of 80% of the postdonation decrease in hemoglobin | Human | blood donors with higher ferritin (>26 ng/mL) | 37.5 mg elemental iron (as ferrous gluconate) daily. | Oral iron supplementation after blood donation: a randomized clinical trial.cited 120× |
| low-dose iron supplementation | Decreases - reduced time to 80% recovery of the postdonation decrease in hemoglobin concentration | time to 80% recovery of the postdonation decrease in hemoglobin concentration | Human | blood donors with normal hemoglobin levels, with low ferritin (≤26 ng/mL) or higher ferritin (>26 ng/mL) | 37.5 mg elemental iron (as ferrous gluconate) daily. | Oral iron supplementation after blood donation: a randomized clinical trial.cited 120× |
| donkey bone collagen peptide iron chelate (DPI) | Increases - significantly increased | hemoglobin (Hb) levels | Animal | immunosuppressed mice | — | Interventional Effect of Donkey Bone Collagen Peptide Iron Chelate on Cyclophosphamide Induced Immunosuppressive Mice. |
| donkey bone collagen peptide iron chelate (DPI) | Increases - significantly increased | hemoglobin (Hb) levels | Animal | immunosuppressed mice | — | Interventional Effect of Donkey Bone Collagen Peptide Iron Chelate on Cyclophosphamide Induced Immunosuppressive Mice. |
| donkey bone collagen peptide iron chelate (DPI) | Increases - significantly increased | mean corpuscular hemoglobin concentration (MCHC) levels | Animal | immunosuppressed mice | — | Interventional Effect of Donkey Bone Collagen Peptide Iron Chelate on Cyclophosphamide Induced Immunosuppressive Mice. |
| donkey bone collagen peptide iron chelate (DPI) | Increases - significantly increased | mean corpuscular hemoglobin concentration (MCHC) levels | Animal | immunosuppressed mice | — | Interventional Effect of Donkey Bone Collagen Peptide Iron Chelate on Cyclophosphamide Induced Immunosuppressive Mice. |
| donkey bone collagen peptide iron chelate (DPI) | Increases - significantly increased | mean corpuscular hemoglobin (MCH) levels | Animal | immunosuppressed mice | — | Interventional Effect of Donkey Bone Collagen Peptide Iron Chelate on Cyclophosphamide Induced Immunosuppressive Mice. |
| donkey bone collagen peptide iron chelate (DPI) | Increases - significantly increased | mean corpuscular hemoglobin (MCH) levels | Animal | immunosuppressed mice | — | Interventional Effect of Donkey Bone Collagen Peptide Iron Chelate on Cyclophosphamide Induced Immunosuppressive Mice. |
| Administration of IV iron supplements during or immediately after surgery | Decreases - significantly reduced | the amount of change in hemoglobin | Human | Patients undergoing primary total knee arthroplasty | Not specified | Effects of intraoperative or postoperative administration of intravenous iron supplements on hemoglobin recovery in patients with total knee arthroplasty: A systematic review and meta-analysis.cited 5× |
| Administration of IV iron supplements during or after TKA surgery | Increases - increases | hemoglobin recovery between 4 and 8 weeks after surgery | Human | patients undergoing primary total knee arthroplasty | Not specified | Effects of intraoperative or postoperative administration of intravenous iron supplements on hemoglobin recovery in patients with total knee arthroplasty: A systematic review and meta-analysis.cited 5× |
| oral iron syrup (3 mg/kg/day elemental iron) plus one sesame jaggery ball (containing 60 g of sesame seeds and jaggery each) | Increases - increased | hemoglobin (Hb) levels | Human | children aged 6-11 years diagnosed with moderate iron deficiency anemia | 3 mg/kg/day elemental iron syrup + one sesame jaggery ball (60g sesame seeds and 60g jaggery) daily. | Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial.cited 1× |
| oral iron syrup (3 mg/kg/day elemental iron) plus one sesame jaggery ball (containing 60 g of sesame seeds and jaggery each) | Increases - increased | hemoglobin (Hb) levels | Human | children aged 6-11 years diagnosed with moderate iron deficiency anemia | 3 mg/kg/day elemental iron syrup + one sesame jaggery ball (60g sesame seeds and 60g jaggery) daily. | Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial.cited 1× |
| oral iron syrup (3 mg/kg/day elemental iron) | Increases - increased | hemoglobin (Hb) levels | Human | children aged 6-11 years diagnosed with moderate iron deficiency anemia | 3 mg/kg/day elemental iron syrup + one sesame jaggery ball (60g sesame seeds and 60g jaggery) daily. | Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial.cited 1× |
| oral iron syrup (3 mg/kg/day elemental iron) | Increases - increased | hemoglobin (Hb) levels | Human | children aged 6-11 years diagnosed with moderate iron deficiency anemia | 3 mg/kg/day elemental iron syrup + one sesame jaggery ball (60g sesame seeds and 60g jaggery) daily. | Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial.cited 1× |
| iron supplementation | Increases - has been evaluated for its potential to increase | baseline hemoglobin | Human | cardiac surgery patients | Not specified | Iron supplementation for patients undergoing cardiac surgery: a systematic review and meta-analysis of randomized controlled trials.cited 12× |
| iron supplementation (≤60 mg/day group) | No effect - comparable change in | blood hemoglobin levels | Human | participants | 30 mg/day, 60 mg/day, and >60 mg/day of elemental iron | Efficacy of different doses of daily prophylactic iron supplementation in pregnant women: A systematic review and meta-analysis. |
| iron supplementation (>60 mg/day group) | No effect - comparable change in | blood hemoglobin levels | Human | participants | 30 mg/day, 60 mg/day, and >60 mg/day of elemental iron | Efficacy of different doses of daily prophylactic iron supplementation in pregnant women: A systematic review and meta-analysis. |
| iron supplementation | Increases - difference in the mean delivery hemoglobin | delivery hemoglobin | Human | non-anemia group | Not specified | The effect of iron supplementation on maternal iron deficiency anemia does not differ by baseline anemia type among Tanzanian pregnant women without severe iron deficiency anemia.cited 4× |
| iron supplementation | Increases - difference in the mean delivery hemoglobin | delivery hemoglobin | Human | NIDA group | Not specified | The effect of iron supplementation on maternal iron deficiency anemia does not differ by baseline anemia type among Tanzanian pregnant women without severe iron deficiency anemia.cited 4× |
| iron supplementation | Increases - difference in the mean delivery hemoglobin | delivery hemoglobin | Human | IDA group | Not specified | The effect of iron supplementation on maternal iron deficiency anemia does not differ by baseline anemia type among Tanzanian pregnant women without severe iron deficiency anemia.cited 4× |
| iron supplementation (325 mg/day of ferrous sulphate) | No effect - experienced no changes | hemoglobin (Hb) | Human | iron treatment group (ITG) | 325 mg/day of ferrous sulphate. | Iron supplementation prevents a decline in iron stores and enhances strength performance in elite female volleyball players during the competitive season.cited 19× |
| iron supplementation | Increases - significantly improved the mean increase from baseline to delivery for | hemoglobin | Human | pregnant women in Dar es Salaam, Tanzania | 60 mg of iron, administered every 4 weeks. | Iron Supplementation in Iron-Replete and Nonanemic Pregnant Women in Tanzania: A Randomized Clinical Trial.cited 47× |
| iron supplementation | Increases - appears to change more | hemoglobin | Human | — | Not specified | Systematic review of randomized trials of the effect of iron supplementation on iron stores and oxygen carrying capacity in pregnancy.cited 17× |
| oral iron supplementation | Increases - statistically significant increases | hemoglobin levels | Human | pregnant women with non-anemic iron deficiency | Not specified | Systematic review of randomized trials of the effect of iron supplementation on iron stores and oxygen carrying capacity in pregnancy.cited 17× |
| intravenous iron supplementation | Increases - statistically significant increases | hemoglobin levels | Human | pregnant women with iron deficiency anemia | Not specified | Systematic review of randomized trials of the effect of iron supplementation on iron stores and oxygen carrying capacity in pregnancy.cited 17× |
| iron supplementation | No effect - had similar mean values | hemoglobin | Human | children with CM or SMA and iron-deficient community children | Not specified | Comparison of iron status 28 d after provision of antimalarial treatment with iron therapy compared with antimalarial treatment alone in Ugandan children with severe malaria.cited 10× |
| iron supplementation | No effect - maintained | hemoglobin (Hb) | Human | iron treatment group (ITG) | Not specified | Eleven Weeks of Iron Supplementation Does Not Maintain Iron Status for an Entire Competitive Season in Elite Female Volleyball Players: A Follow-Up Study.cited 9× |
| iron supplementation | Increases - increased | hemoglobin | Human | nonanemic iron-deficient women with unexplained fatigue | 80 mg elemental iron (as ferrous sulfate) daily. | Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial.cited 111× |
| iron supplementation | Increases - significantly increased | hemoglobin | Human | iron-deficient patients on maintenance hemodialysis (MHD) | Oral iron (50 mg sodium ferrous citrate daily) or intravenous iron (40 mg saccharated ferric oxide weekly). | Oral Versus Intravenous Iron Supplementation for the Treatment of Iron Deficiency Anemia in Patients on Maintenance Hemodialysis-Effect on Fibroblast Growth Factor-23 Metabolism.cited 24× |
| Iron supplementation | Increases - should be used to optimize | hemoglobin concentration | Human | patients before delivery | Not specified | Patient Blood Management programs for post-partum hemorrhage.cited 3× |
| iron supplementation | Increases - effectively increased | hemoglobin concentrations (Hb) | Human | CRC surgery patients | Not specified | Iron Supplementation Effectively Ameliorates Anemia and Reduces the Need for Blood Transfusion in Patients Undergoing Colorectal Cancer Surgery: A Meta-Analysis.cited 3× |
| iron supplementation | Decreases - -0.08 g/dL per 10-μg/L increase in baseline SF concentration | hemoglobin concentrations | Human | — | Not specified (study analyzed effects per gram of iron but did not list exact dosages). | Effect of iron intake on iron status: a systematic review and meta-analysis of randomized controlled trials.cited 50× |
| iron supplementation | Increases - treatment targets for ID included an increase | hemoglobin concentrations | Human | — | Not specified | Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review.cited 206× |
| iron supplementation | Increases - demonstrated the increase of | hemoglobin level | Human | patients undergoing hip or knee surgery | Not specified | Efficacy and safety of iron supplementation for the elderly patients undergoing hip or knee surgery: a meta-analysis of randomized controlled trials.cited 36× |
| Iron supplementation | Increases - resulting in an increased | hemoglobin level | Human | — | Not specified | SAFETY AND EFFICACY OF INTRAVENOUS ADMINISTRATION OF IRON PREPARATIONS.cited 11× |
| iron supplementation | No effect - no significant differences | hemoglobin levels | Human | preterm infants | Not specified | Effects of early parenteral iron combined erythropoietin in preterm infants: A randomized controlled trial.cited 11× |
| iron supplementation combined erythropoietin | No effect - no significant differences | hemoglobin levels | Human | preterm infants | Not specified | Effects of early parenteral iron combined erythropoietin in preterm infants: A randomized controlled trial.cited 11× |
| iron supplementation | No effect - No significant alterations | hemoglobin levels | Human | Group II patients (anemic H. pylori-infected) | Not specified | Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: effect of treatment.cited 5× |
| iron supplementation and anti-H pylori therapy | Increases - significant increase | hemoglobin levels | Human | Group I patients (anemic H. pylori-infected) | Not specified | Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: effect of treatment.cited 5× |
| iron supplementation | No effect - benefits were independent | hemoglobin levels | Human | — | Not specified | Targeting Iron Deficiency Anemia in Heart Failure.cited 7× |
| iron supplementation | Increases - increases | hemoglobin levels | Human | patients with CKD | Ferumoxytol (1.02 g over 2 doses) or iron sucrose (1.0 g over 10 doses) during a 5-week treatment period. | The Ferumoxytol for Anemia of CKD Trial (FACT)-a randomized controlled trial of repeated doses of ferumoxytol or iron sucrose in patients on hemodialysis: background and rationale.cited 7× |
| iron sucrose | No effect - mean change in | hemoglobin from Baseline to Week 5 | Human | adults with IDA receiving hemodialysis | Ferumoxytol (1.02 g over 2 doses) or iron sucrose (1.0 g over 10 doses) during a 5-week treatment period. | The Ferumoxytol for Anemia of CKD Trial (FACT)-a randomized controlled trial of repeated doses of ferumoxytol or iron sucrose in patients on hemodialysis: background and rationale.cited 7× |
| iron sucrose | Increases - proportion of patients with | hemoglobin increase of ≥1.0 g/dL at any time from Baseline to Week 5 | Human | adults with IDA receiving hemodialysis | Ferumoxytol (1.02 g over 2 doses) or iron sucrose (1.0 g over 10 doses) during a 5-week treatment period. | The Ferumoxytol for Anemia of CKD Trial (FACT)-a randomized controlled trial of repeated doses of ferumoxytol or iron sucrose in patients on hemodialysis: background and rationale.cited 7× |
| iron supplementation | Increases - should be administered, with the goal of normalizing | hemoglobin levels and replenishing iron stores | Human | — | Not specified for bariatric surgery (iron supplementation: 100-200 mg daily elemental iron). | Diagnosis and treatment of unexplained anemia with iron deficiency without overt bleeding.cited 31× |
| iron supplementation | Increases - increased | hemoglobin response rate | Human | patients receiving ESAs and concomitant chemotherapy | Not specified | Anemia treatment of lymphoproliferative malignancies with erypoiesis: an overview of state of the art. |
| Iron supplementation | No effect - there is no evidence that is needed | maternal hemoglobin | Human | women with hemoglobin of 7 g/dL or more | Not specified | Current Concepts of Maternal Nutrition.cited 81× |
| iron supplementation | Increases - increases | maternal hemoglobin concentrations | Human | — | Not specified | A review of the impact of dietary intakes in human pregnancy on infant birthweight.cited 125× |
| iron supplementation | Increases - had significantly higher | mean hemoglobin levels | Human | non-anemic patients undergoing major surgeries | Not specified | Preoperative iron supplementation in non-anemic patients undergoing major surgery: a systematic review and meta-analysis. |
| iron supplementation | No effect - could not rule out the null hypothesis for the difference in | mean hemoglobin levels throughout the first week | Human | non-anemic patients undergoing major surgeries | Not specified | Preoperative iron supplementation in non-anemic patients undergoing major surgery: a systematic review and meta-analysis. |
| iron supplementation | No effect - similar | mean hemoglobin values | Human | infants in the supplemented and control groups | 1 mg/kg/day ferrous sulfate | Effect of iron supplementation on development of iron deficiency anemia in breastfed infants.cited 6× |
| dietary iron intake | Increases - significant positive correlation | hemoglobin levels | Human | infants | 1 mg/kg/day ferrous sulfate | Effect of iron supplementation on development of iron deficiency anemia in breastfed infants.cited 6× |
| iron supplementation | Decreases - was a condition for inclusion | total hemoglobin | Human | nulliparous women with preeclampsia moderate degree and severe degree | Not specified (iron supplementation was given when total hemoglobin was < 115 g/l). | PREECLAMPSIA AND IRON EXCHANGE. ARE THERE ANY COMMON PATTERNS?cited 5× |
| oral iron supplements alone | Increases - change in hemoglobin level | hemoglobin level | Human | patients with iron deficiency anemia (IDA) | 100-mg oral iron tablet every 8 hours daily, with or without 200 mg of vitamin C. | The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial.cited 48× |
| oral iron supplements alone | No effect - were equivalent to oral iron supplements plus vitamin C | hemoglobin recovery and iron absorption | Human | patients with IDA | 100-mg oral iron tablet every 8 hours daily, with or without 200 mg of vitamin C. | The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial.cited 48× |
| oral iron supplements plus vitamin C | Increases - change in hemoglobin level | hemoglobin level | Human | patients with iron deficiency anemia (IDA) | 100-mg oral iron tablet every 8 hours daily, with or without 200 mg of vitamin C. | The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial.cited 48× |
| MMS containing a daily allowance of 15 micronutrients, including 30 mg of iron and 400 μg of folic acid | No effect - no significant differences | maternal hemoglobin level at 30 weeks' gestation | Human | pregnant women | 30 mg of iron and 400 μg of folic acid daily (in MMS group); 60 mg of iron and 400 μg of folic acid daily (in another group). | Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial.cited 153× |
| capsules of 30 mg of iron and 400 μg of folic acid | No effect - no significant differences | maternal hemoglobin level at 30 weeks' gestation | Human | pregnant women | 30 mg of iron and 400 μg of folic acid daily (in MMS group); 60 mg of iron and 400 μg of folic acid daily (in another group). | Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial.cited 153× |
| capsules of 60 mg of iron and 400 μg of folic acid | No effect - no significant differences | maternal hemoglobin level at 30 weeks' gestation | Human | pregnant women | 30 mg of iron and 400 μg of folic acid daily (in MMS group); 60 mg of iron and 400 μg of folic acid daily (in another group). | Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial.cited 153× |
| iron syrup | Increases - improvements | hemoglobin concentrations | Human | children | 12.5 mg iron daily (as iron syrup or in MNPs). | Effects of iron supplementation on neural indices of habituation in Bangladeshi children.cited 4× |
| Iron supplementation during pregnancy | Increases - led to increased | fetal hemoglobin | Human | fetus | Not specified | Correlation of rheological parameters in maternal and fetal blood at term.cited 2× |
| therapeutic iron | Increases - rose | median hemoglobin | Human | clinically anemic children who took iron | Not specified | Anemia, diet and therapeutic iron among children living with HIV: a prospective cohort study.cited 23× |
| therapeutic iron | Increases - peaked | median hemoglobin | Human | clinically anemic children who took iron | Not specified | Anemia, diet and therapeutic iron among children living with HIV: a prospective cohort study.cited 23× |
| recombinant human erythropoietin with oral iron supplements | Increases - average increase was significantly higher | hemoglobin | Human | pregnant women diagnosed with iron deficiency anemia | Group II received 1000 IU EPO intravenously every three days with oral iron supplements; Group I received Ferrum Lek intramuscularly every two days. | Use of alternative methods in the treatment of anemia in pregnant women - prospective observational study.cited 2× |
| recombinant human erythropoietin with oral iron supplements | No effect - increase did not correlate | hemoglobin | Human | pregnant women diagnosed with iron deficiency anemia | Group II received 1000 IU EPO intravenously every three days with oral iron supplements; Group I received Ferrum Lek intramuscularly every two days. | Use of alternative methods in the treatment of anemia in pregnant women - prospective observational study.cited 2× |
| recombinant human erythropoietin with oral iron supplements | No effect - increase did not correlate | hemoglobin | Human | pregnant women diagnosed with iron deficiency anemia | Group II received 1000 IU EPO intravenously every three days with oral iron supplements; Group I received Ferrum Lek intramuscularly every two days. | Use of alternative methods in the treatment of anemia in pregnant women - prospective observational study.cited 2× |
| recombinant human erythropoietin with oral iron supplements | Decreases - negative correlation was found | hemoglobin | Human | pregnant women diagnosed with iron deficiency anemia | Group II received 1000 IU EPO intravenously every three days with oral iron supplements; Group I received Ferrum Lek intramuscularly every two days. | Use of alternative methods in the treatment of anemia in pregnant women - prospective observational study.cited 2× |
| non-heme iron (FeSO4) | Increases - significantly increased | hemoglobin | Human | women post-RYGB and iron deficient | Not specified in the abstract. | Comparison of Oral Iron Supplement Formulations for Normalization of Iron Status Following Roux-EN-y Gastric Bypass Surgery: a Randomized Trial.cited 21× |
| heme iron (proferrin) | No effect - did not significantly change | hemoglobin | Human | women post-RYGB and iron deficient | Not specified in the abstract. | Comparison of Oral Iron Supplement Formulations for Normalization of Iron Status Following Roux-EN-y Gastric Bypass Surgery: a Randomized Trial.cited 21× |
| early iron supplementation | Decreases - was associated with significantly smaller decreases | hemoglobin levels | Human | low birth weight infants | Not specified (timing ranged from as early as enteral feeding was tolerated to 3 weeks for early supplementation and 4 weeks to about 60 days for late supplementation). | Early and late Iron supplementation for low birth weight infants: a meta-analysis.cited 18× |
| iron supplementation, 66 mg elemental iron daily as ferrous fumarate | Increases - had higher | hemoglobin (Hb) | Human | the iron group | 66 mg elemental iron daily as ferrous fumarate. | Iron supplementation in pregnant Danish women revisited: Effects on prepartum and postpartum iron deficiency, anemia, serum erythropoietin; including iron status, erythropoietin and anthropometrics in newborns. A randomized, placebo-controlled study.cited 4× |
| oral iron supplementation | Increases - a significant increase | hemoglobin | Human | patients with low Ret He | Not specified | Reticulocyte Hemoglobin Content (Ret He): A Simple Tool for Evaluation of Iron Status in Childhood Cancer.cited 6× |
| oral iron supplementation | Increases - greater hemoglobin improvement | hemoglobin concentration | Human | anemic patients with IBD | Not specified | Follow-up evaluation and management of anemia in inflammatory bowel disease: A study by the Italian Group for Inflammatory Bowel Diseases (IG-IBD).cited 3× |
| parenteral iron supplementation | Increases - greater hemoglobin improvement | hemoglobin concentration | Human | anemic patients with IBD | Not specified | Follow-up evaluation and management of anemia in inflammatory bowel disease: A study by the Italian Group for Inflammatory Bowel Diseases (IG-IBD).cited 3× |
| Intravenous iron versus oral iron | Increases - showing a significantly greater increase | hemoglobin levels | Human | hemodialysis patients | Not specified | Use of intravenous iron supplementation in chronic kidney disease: an update.cited 39× |
| oral iron-replacement therapy | Increases - most accurately predicted satisfactory overall hemoglobin response | A ≥1.0-g/dL increase in hemoglobin on day 14 | Human | subjects with iron-deficiency anemia | Not specified | Iron Supplementation, Response in Iron-Deficiency Anemia: Analysis of Five Trials.cited 42× |
| oral iron-replacement therapy | No effect - may be useful in assessing whether and when to transition patients | Hemoglobin response at day 14 | Human | patients with iron-deficiency anemia | Not specified | Iron Supplementation, Response in Iron-Deficiency Anemia: Analysis of Five Trials.cited 42× |
| oral iron-replacement therapy | Increases - was greatest among | The proportion of subjects with hemoglobin increases ≥1.0, ≥2.0, and ≥3.0 g/dL | Human | subjects with postpartum anemia | Not specified | Iron Supplementation, Response in Iron-Deficiency Anemia: Analysis of Five Trials.cited 42× |
| oral iron-replacement therapy | Increases - was intermediate among | The proportion of subjects with hemoglobin increases ≥1.0, ≥2.0, and ≥3.0 g/dL | Human | subjects with heavy uterine bleeding or gastrointestinal-related causes of anemia | Not specified | Iron Supplementation, Response in Iron-Deficiency Anemia: Analysis of Five Trials.cited 42× |
| oral iron-replacement therapy | Increases - was lowest among | The proportion of subjects with hemoglobin increases ≥1.0, ≥2.0, and ≥3.0 g/dL | Human | subjects with other causes of anemia | Not specified | Iron Supplementation, Response in Iron-Deficiency Anemia: Analysis of Five Trials.cited 42× |
| oral iron-replacement therapy | Increases - was significantly greater among | The proportion of subjects with hemoglobin increases ≥1.0, ≥2.0, and ≥3.0 g/dL | Human | responders | Not specified | Iron Supplementation, Response in Iron-Deficiency Anemia: Analysis of Five Trials.cited 42× |
| oral iron | Increases - identify subjects who should be transitioned to IV iron supplementation | Hemoglobin responses <1.0 g/dL at day 14 | Human | subjects with iron-deficiency anemia | Not specified | Iron Supplementation, Response in Iron-Deficiency Anemia: Analysis of Five Trials.cited 42× |
| treatment with both ESA and iron | Increases - increased | hemoglobin | Human | — | Not specified | The addition of oral iron improves chemotherapy-induced anemia in patients receiving erythropoiesis-stimulating agents. |
| no iron therapy | Increases - mean rise | hemoglobin levels | Human | patients with a hemoglobin level of <110 g/L after treatment for a hip fracture | 28-day course of ferrous sulfate (specific dosage not mentioned). | Iron supplementation for anemia after hip fracture surgery: a randomized trial of 300 patients.cited 52× |
| daily oral iron therapy | Increases - mean increase in hemoglobin | hemoglobin | Human | patients of IDA | 60mg of elemental iron (ferrous sulfate), either daily or on alternate days. | A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia.cited 14× |
| alternate day oral iron therapy | Increases - mean increase in hemoglobin was significantly more | hemoglobin | Human | patients of IDA | 60mg of elemental iron (ferrous sulfate), either daily or on alternate days. | A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia.cited 14× |
| perioperative iron | Increases - significantly increased | postintervention hemoglobin | Human | patients in one RCT | Not specified (oral and intravenous iron were used, but exact dosages not detailed). | The impact of perioperative iron on the use of red blood cell transfusions in gastrointestinal surgery: a systematic review and meta-analysis.cited 38× |
| Both IV and oral iron | Increases - can effectively raise | hemoglobin levels | Human | iron-deficiency anemia | One ferrous sulfate tablet per day (low-dose oral iron). | Supplementation with oral vs. intravenous iron for anemia with IBD or gastrointestinal bleeding: is oral iron getting a bad rap?cited 32× |
| IV iron | No effect - no evidence that can raise | hemoglobin | Human | — | One ferrous sulfate tablet per day (low-dose oral iron). | Supplementation with oral vs. intravenous iron for anemia with IBD or gastrointestinal bleeding: is oral iron getting a bad rap?cited 32× |
| Intermittent iron supplementation | Increases - significantly improves | hemoglobin concentration | Human | children | Not specified | Interventions to address maternal and childhood undernutrition: current evidence.cited 12× |
| preoperative intravenous (IV) iron infusion | Increases - optimizing | hemoglobin (Hb) levels | Human | anemic colorectal cancer patients | Not specified | Short-term effect of preoperative intravenous iron therapy in colorectal cancer patients with anemia: results of a cohort study.cited 33× |
| Intravenous iron | Increases - rise | hemoglobin levels | Human | hemodialysis patients | Not specified | Iron toxicity: relevance for dialysis patients.cited 53× |
| intravenous iron | Increases - resultant increased | hemoglobin levels | Human | patients with HF having iron-deficiency anemia | Not specified | Treatment of anemia in heart failure: potential risks and benefits of intravenous iron therapy in cardiovascular disease.cited 13× |
| intravenous iron | Increases - increases the likelihood of maintaining | levels of hemoglobin within the desired range | Human | patients on hemodialysis | Not specified | Iron supplementation to treat anemia in patients with chronic kidney disease.cited 96× |
| intravenous iron supplementation | Increases - significantly higher values | hemoglobin | Human | non-anemic repeat adult blood donors with iron deficiency (ferritin ≤ 50 µg/L) | Single intravenous dose of 800 mg iron-carboxymaltose. | The effects of intravenous iron supplementation on fatigue and general health in non-anemic blood donors with iron deficiency: a randomized placebo-controlled superiority trial.cited 16× |
| intravenous iron supplementation | Increases - resulted in increase | hemoglobin levels | Human | repeat blood donors with low iron stores | Single intravenous dose of 800 mg iron-carboxymaltose. | The effects of intravenous iron supplementation on fatigue and general health in non-anemic blood donors with iron deficiency: a randomized placebo-controlled superiority trial.cited 16× |
| intravenous iron supplementation | Increases - modest hemoglobin concentrations rise | hemoglobin concentrations | Human | — | Not specified in the abstract. | Role of preoperative intravenous iron therapy to correct anemia before major surgery: a systematic review and meta-analysis.cited 40× |
| IV iron | Increases - increased | hemoglobin levels | Human | — | Not specified in the abstract. | Role of preoperative intravenous iron therapy to correct anemia before major surgery: a systematic review and meta-analysis.cited 40× |
| IV iron | Increases - increased | hemoglobin levels | Human | — | Not specified in the abstract. | Role of preoperative intravenous iron therapy to correct anemia before major surgery: a systematic review and meta-analysis.cited 40× |
| Intravenous iron supplementation | Increases - may be suggested to increase | peripartum hemoglobin levels | Human | peripartum patients | Not specified | Strategies to reduce blood product utilization in obstetric practice.cited 9× |
| 40 mg intravenous elemental iron doses at all three hemodialysis sessions in the first week (IW1 group) | Increases - Increases in total reticulocyte hemoglobin were higher | total reticulocyte hemoglobin | Human | hemodialysis patients | 40 mg intravenous elemental iron doses at all three hemodialysis sessions in the first or third week after CERA administration | Acceleration of iron utilization after intravenous iron administration during activated erythropoiesis in hemodialysis patients: a randomized study.cited 7× |
| 40 mg intravenous elemental iron doses at all three hemodialysis sessions in the third week (IW3 group) | Increases - only tendency toward greater total reticulocyte hemoglobin | total reticulocyte hemoglobin | Human | hemodialysis patients | 40 mg intravenous elemental iron doses at all three hemodialysis sessions in the first or third week after CERA administration | Acceleration of iron utilization after intravenous iron administration during activated erythropoiesis in hemodialysis patients: a randomized study.cited 7× |
| oral Heme Iron Polypeptide (HIP) | No effect - is similar in efficacy to | hemoglobin | Human | ND-CKD patients | HIP 11 mg orally 3 times per day; IV iron sucrose 200 mg monthly. | Heme iron polypeptide for the treatment of iron deficiency anemia in non-dialysis chronic kidney disease patients: a randomized controlled trial.cited 24× |
| Iron oxides nanoparticles (FeO NPs) | Increases - significantly increased | hemoglobin concentration | Animal | iron-deficient rats | — | Metabolomics reveals the role of acetyl-l-carnitine metabolism in γ-Fe |
| parenteral or oral iron supplementation | Increases - can restore iron stores and maintain stable hemoglobin levels | iron stores and hemoglobin levels | Human | chronic kidney disease (CKD) and hemodialysis (HD) patients | Low-dose ferrous bisglycinate chelate (specific amount not provided). | Low-dose ferrous bisglycinate chelate supplementation in chronic kidney disease and hemodialysis patients.cited 3× |
| low-dose iron supplement | No effect - adjusted to maintain | hemoglobin level | Human | outpatients on maintenance hemodialysis | Low-dose iron supplement and recombinant human erythropoietin doses adjusted to maintain hemoglobin levels of 10-11 g/dL. | Low levels of serum ferritin and moderate transferrin saturation lead to adequate hemoglobin levels in hemodialysis patients, retrospective observational study.cited 8× |
| control diet with iron supplementation | Increases - were significantly higher | hemoglobin concentrations | Human | SG | Not specified (low-dose iron supplementation mentioned). | A randomized controlled trial in young women of the effects of consuming pork meat or iron supplements on nutritional status and feeling of well-being.cited 13× |
| Iron replacement | Increases - may be used to improve | hemoglobin response | Human | patients receiving ESA with or without iron deficiency | Not specified | Management of Cancer-Associated Anemia With Erythropoiesis-Stimulating Agents: ASCO/ASH Clinical Practice Guideline Update.cited 76× |
| iron replacement | Increases - may be used to improve | hemoglobin response | Human | patients receiving ESA with or without iron deficiency | Not specified | Management of cancer-associated anemia with erythropoiesis-stimulating agents: ASCO/ASH clinical practice guideline update.cited 60× |
| 1000 IU/day vitamin D3 plus 27 mg/day iron (D-Fe) | Increases - increases | mean corpuscular hemoglobin concentration (MCHC) | Human | women with hemoglobin (Hb) ≤ 12.7 g/dL and 25OHD ≤ 29 ng/mL vitamin D deficiency/insufficiency aged 18-45 years | 27 mg/day iron plus 1000 IU/day vitamin D3. | Changes in Bone Turnover, Inflammatory, Oxidative Stress, and Metabolic Markers in Women Consuming Iron plus Vitamin D Supplements: a Randomized Clinical Trial.cited 1× |
| colloidal iron | Increases - rise | hemoglobin levels | Human | children with iron deficiency anemia | Elemental iron 3 mg/kg body weight per day. | Treatment of iron deficiency anemia in children: a comparative study of ferrous ascorbate and colloidal iron.cited 13× |
| i.v. iron supplementation | Decreases - reduces the time to | target hemoglobin levels | Human | patients with cancer-related anemia | Not specified | Iron replacement therapy in cancer-related anemia.cited 19× |
| i.v. iron | No effect - were not consistently raised | hemoglobin levels | Human | non-hemodialysis-dependent patients with chronic kidney disease (CKD) | Not specified | Intravenous versus oral iron for treatment of iron deficiency in non-hemodialysis-dependent patients with chronic kidney disease.cited 9× |
| iron sucrose | Decreases - changed by | hemoglobin | Human | patients on prevalent hemodialysis | Equal cumulative doses of ferric carboxymaltose (less frequent, higher single doses) and iron sucrose (more frequent, lower single doses). | Comparison of Iron Dosing Strategies in Patients Undergoing Long-Term Hemodialysis: A Randomized Controlled Trial.cited 4× |
| Iron Sucrose i.v. 200 mg, once a week, for 5 weeks | Increases - increased similarly | hemoglobin | Human | anemic heart failure patients with preserved renal function, low transferrin saturation (TSat) and low-to-moderately elevated ferritin levels | Iron Sucrose i.v. 200 mg once a week for 5 weeks; ferrous sulfate 200 mg p.o. three times daily for 8 weeks. | IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia.cited 174× |
| intravenous iron sucrose | Increases - efficacy in improving | hemoglobin | Human | anemic pregnant women | Not specified | Is intravenous iron sucrose the treatment of choice for pregnant anemic women?cited 8× |
| intravenous (IV) iron sucrose | Increases - A statistically significant increase in the mean Hb and serum ferritin levels was observed | hemoglobin (Hb) and serum ferritin levels | Human | pregnant women with moderate to severe IDA in the second or third trimester | Not specified in the abstract. | Evaluation of therapeutic response and tolerability to intravenous iron sucrose and ferric carboxymaltose among pregnant women with iron?deficiency anemia: A 6?year experience in a tertiary care center. |
| two cycles of 20 daily doses of 30 mg elemental iron separated by a four-month period | Increases - increased | mean hemoglobin concentration | Human | under five-year-old children who attended government daycare centers | Weekly Group: 30 mg elemental iron weekly (40 doses); Cyclical Group: two cycles of 20 daily doses of 30 mg elemental iron (40 doses total). | Cyclical iron supplementation to reduce anemia among Brazilian preschoolers: a randomized controlled trial.cited 5× |
| two cycles of 20 daily doses of 30 mg elemental iron separated by a four-month period | No effect - no significant difference | mean hemoglobin concentration | Human | under five-year-old children who attended government daycare centers | Weekly Group: 30 mg elemental iron weekly (40 doses); Cyclical Group: two cycles of 20 daily doses of 30 mg elemental iron (40 doses total). | Cyclical iron supplementation to reduce anemia among Brazilian preschoolers: a randomized controlled trial.cited 5× |
| weekly doses of 30 mg elemental iron | Increases - increased | mean hemoglobin concentration | Human | under five-year-old children who attended government daycare centers | Weekly Group: 30 mg elemental iron weekly (40 doses); Cyclical Group: two cycles of 20 daily doses of 30 mg elemental iron (40 doses total). | Cyclical iron supplementation to reduce anemia among Brazilian preschoolers: a randomized controlled trial.cited 5× |
| weekly doses of 30 mg elemental iron | No effect - no significant difference | mean hemoglobin concentration | Human | under five-year-old children who attended government daycare centers | Weekly Group: 30 mg elemental iron weekly (40 doses); Cyclical Group: two cycles of 20 daily doses of 30 mg elemental iron (40 doses total). | Cyclical iron supplementation to reduce anemia among Brazilian preschoolers: a randomized controlled trial.cited 5× |
| iron rich snacks cooked in iron pots | Increases - a significant increase of 7.9 % was seen | hemoglobin | Human | preschool children | Mean iron content of 2.1mg per serving (frequency not specified). | Beneficial effect of iron pot cooking on iron status.cited 10× |
| liposomal iron 14 mg (LI14) | Increases - showed significantly higher | hemoglobin concentrations | Human | healthy pregnant women | Ferrous iron 30 mg, liposomal iron 14 mg (Sideral®), and liposomal iron 28 mg daily. | Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: a randomized control trial.cited 34× |
| liposomal iron 28 mg/daily (LI28) | Increases - showed significantly higher | hemoglobin concentrations | Human | healthy pregnant women | Ferrous iron 30 mg, liposomal iron 14 mg (Sideral®), and liposomal iron 28 mg daily. | Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: a randomized control trial.cited 34× |
| a combination of Lf and elemental iron | Increases - were found to be increased | hemoglobin (Hb) | Human | children with IDA | Not specified in the abstract. | Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review. |
| daily dosing of iron | Increases - raise | hemoglobin (Hb) | Human | pregnant women with iron deficiency anemia | Not specified | Daily versus Alternate-Day Iron Supplementation for Pregnant Women with Iron Deficiency Anemia: A Randomized Controlled Trial.cited 1× |
| alternate-day dosing of iron | Increases - raise | hemoglobin (Hb) | Human | pregnant women with iron deficiency anemia | Not specified | Daily versus Alternate-Day Iron Supplementation for Pregnant Women with Iron Deficiency Anemia: A Randomized Controlled Trial.cited 1× |
| oral iron supplementation allied with acupuncture weight loss treatment | Increases - brought more obvious improvements | hemoglobin | Human | ID or IDA patients with obesity | Not specified | Acupuncture Improves Intestinal Absorption of Iron in Iron-deficient Obese Patients: A Randomized Controlled Preliminary Trial.cited 6× |
| Addition of guava to a mungbean-based meal containing a moderate amount of iron | Increases - increased | hemoglobin | Human | children | ~170 mg vitamin C daily (via guava) with 3.2 mg iron. | Vitamin C-Rich Guava Consumed with Mungbean Dal Reduces Anemia and Increases Hemoglobin but not Iron Stores: A Randomized Controlled Trial of Food-to-Food Fortification in Indian Children. |
| iddli four times a week plus information, education, and communication (IEC) related to iron-deficiency anemia | Increases - improved significantly | hemoglobin status | Human | young working women 18 to 23 years of age | Iddli four times a week. | Iron-deficiency anemia in young working women can be reduced by increasing the consumption of cereal-based fermented foods or gooseberry juice at the workplace.cited 4× |
| blister packaged Iron-Folic acid (IFA) pills | Increases - had a higher mean hemoglobin level | hemoglobin level | Human | pregnant women at two National Referral Hospitals in Kampala, Uganda | 30 IFA pills (one pill per day). | The effect of blister packaging Iron and Folate on adherence to medication and hemoglobin levels among pregnant women at National Referral Hospital antenatal clinics in a low to middle income country: a Randomised Controlled Trial (The IFAd Trial).cited 3× |
| blister packaged Iron-Folic acid (IFA) pills | Increases - had a higher change in hemoglobin level | hemoglobin level | Human | pregnant women at two National Referral Hospitals in Kampala, Uganda | 30 IFA pills (one pill per day). | The effect of blister packaging Iron and Folate on adherence to medication and hemoglobin levels among pregnant women at National Referral Hospital antenatal clinics in a low to middle income country: a Randomised Controlled Trial (The IFAd Trial).cited 3× |
| blister packaged Iron-Folic acid (IFA) pills | No effect - had similar mean hemoglobin level | hemoglobin level | Human | pregnant women at two National Referral Hospitals in Kampala, Uganda | 30 IFA pills (one pill per day). | The effect of blister packaging Iron and Folate on adherence to medication and hemoglobin levels among pregnant women at National Referral Hospital antenatal clinics in a low to middle income country: a Randomised Controlled Trial (The IFAd Trial).cited 3× |
| routine intravenous iron | Increases - effective in improving | hemoglobin level | Human | surgical patients with iron deficiency anemia (IDA) | Not specified | Effectiveness of Preoperative Iron Supplementation in Major Surgical Patients With Iron Deficiency: A Prospective Observational Study.cited 46× |
| iron deficiency | Decreases - presented reduced | hemoglobin | Human | infants with IDA | Only one infant was taking prophylactic ferrous sulfate (specific dosage not provided). | Iron deficiency anemia in infants in Sousa (PB), Brazil: an association with nutritional status.cited 2× |
| daily-supervised administration of iron and folic acid with placebo (control group) | Increases - increased | mean hemoglobin | Human | adolescent girls who completed 90 doses of daily supplementation | Experimental group: iron (60 mg), folic acid (500 mcg), cyanocobalamin (1000 mcg) daily; control group: IFA (iron 60 mg, folic acid 500 mcg) and placebo daily. | Impact of daily-supervised administration of a package of iron and folic acid and vitamin Bcited 6× |
| daily-supervised administration of iron and folic acid with cyanocobalamin (experimental group) | Increases - increased | mean hemoglobin | Human | adolescent girls who completed 90 doses of daily supplementation | Experimental group: iron (60 mg), folic acid (500 mcg), cyanocobalamin (1000 mcg) daily; control group: IFA (iron 60 mg, folic acid 500 mcg) and placebo daily. | Impact of daily-supervised administration of a package of iron and folic acid and vitamin Bcited 6× |
| prebiotics or probiotics (especially Lp299v and GOS) with or without oral iron | No effect - does not conclusively show the benefit | hemoglobin levels | Human | women and children | Major interventions included galacto-oligosaccharide, inulin, and specific probiotic strains (e.g., Lactobacillus plantarum 299v, Lactobacillus reuteri, Lactobacillus acidophilus), but exact dosages were not specified. | Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis.cited 2× |
| prebiotics and/or probiotics with or without iron | No effect - associated with little or no effect | hemoglobin | Human | WRA | Major interventions included galacto-oligosaccharide, inulin, and specific probiotic strains (e.g., Lactobacillus plantarum 299v, Lactobacillus reuteri, Lactobacillus acidophilus), but exact dosages were not specified. | Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis.cited 2× |
| iron pills (19 or 38 mg for 60 days) | Decreases - had decreased | hemoglobin deferrals | Human | frequent donors | 19 or 38 mg iron for 60 days | The operational implications of donor behaviors following enrollment in STRIDE (Strategies to Reduce Iron Deficiency in blood donors).cited 14× |
| IV iron supplementation | Increases - promotes | hemoglobin production | Human | — | Not mentioned | Safety of intravenous iron in hemodialysis patients.cited 17× |
| iron-fortified chocolate biscuits | Increases - increased significantly | hemoglobin | Human | preschool children from rural communities | Not specified (consumed fortified biscuits for 72 days). | Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren.cited 5× |
| iron-fortified chocolate biscuits | Increases - adjusted effect ... was higher than the control group | hemoglobin levels | Human | preschool children from rural communities | Not specified (consumed fortified biscuits for 72 days). | Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren.cited 5× |
| iron-fortified chocolate biscuits | Increases - increased significantly | mean corpuscular hemoglobin | Human | preschool children from rural communities | Not specified (consumed fortified biscuits for 72 days). | Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren.cited 5× |
| iron-fortified chocolate biscuits | Increases - increased | mean corpuscular hemoglobin concentrations | Human | preschool children from rural communities | Not specified (consumed fortified biscuits for 72 days). | Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren.cited 5× |
| fortified biscuits with iron sulfate | No effect - no difference was found between consumers of fortified biscuits with heme iron concentrate or iron sulfate | hemoglobin levels | Human | preschool children from rural communities | Not specified (consumed fortified biscuits for 72 days). | Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren.cited 5× |
| fortified biscuits with heme iron concentrate | No effect - no difference was found between consumers of fortified biscuits with heme iron concentrate or iron sulfate | hemoglobin levels | Human | preschool children from rural communities | Not specified (consumed fortified biscuits for 72 days). | Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren.cited 5× |
| iron therapy | Increases - is recommended to take for 2 months to normalize hemoglobin | hemoglobin | Human | — | Recommended 2 months to normalize hemoglobin, followed by 2-3 months to build iron stores (specific dosage amounts not provided). | Preventing complications by persistence with iron replacement therapy: a comprehensive literature review.cited 4× |
| iron therapy | Increases - some degree of normalization of | hemoglobin level | Human | anemic patients | 330 mg of ferrous fumarate daily. | Effects of iron supplements in individuals with erythropoietic protoporphyria.cited 1× |
| administration of iron | Increases - led to an improvement in | blood hemoglobin | Human | four of the anemic patients | 330 mg of ferrous fumarate daily. | Effects of iron supplements in individuals with erythropoietic protoporphyria.cited 1× |
| parenteral iron | Increases - associated with a more rapid rise | hemoglobin | Human | postpartum period | Not specified | The Use of Parenteral Iron Therapy for the Treatment of Postpartum Anemia.cited 10× |
| daily iron supplementation | Increases - had a mean end point hemoglobin of 6.97 g/L greater than controls | hemoglobin | Human | 2 to 5 year olds | Not specified | Effects of daily iron supplementation in 2- to 5-year-old children: systematic review and meta-analysis.cited 60× |
| weekly iron-folic acid (IFA) | Increases - had hemoglobin levels higher than those in the control arm | hemoglobin levels | Human | adolescents (secondary school students aged 10 to 18 y in Burkina Faso) | Weekly IFA or daily MMS (specific amounts not detailed in the abstract). | School-based supplementation with iron-folic acid or multiple micronutrient tablets to address anemia among adolescents in Burkina Faso: a cluster-randomized trial.cited 2× |
| severe maternal iron deficiency anemia in pregnancy | Decreases - is associated with lower | hemoglobin levels | Human | infants at birth | Not specified | The interplay between maternal-infant anemia and iron deficiency.cited 11× |
| iron- and vitamin D-fortified flavored skim milk | Increases - higher values | hemoglobin | Human | iron-deficient menstruating women | 500 mL/day of fortified flavored skim milk | Effects of an iron or iron and vitamin D-fortified flavored skim milk on iron metabolism: a randomized controlled double-blind trial in iron-deficient women.cited 35× |
| i.v. iron (ferric gluconate) combined with rHuEPO | Increases - showed a significant hemoglobin increase | hemoglobin | Human | 148 advanced cancer patients undergoing chemotherapy | Ferric gluconate (125 mg i.v. weekly) or lactoferrin (200 mg/day) | Efficacy and safety of oral lactoferrin supplementation in combination with rHuEPO-beta for the treatment of anemia in advanced cancer patients undergoing chemotherapy: open-label, randomized controlled study.cited 48× |
| i.v. iron (ferric gluconate) combined with rHuEPO | No effect - no difference in the mean hemoglobin increase | mean hemoglobin increase | Human | 148 advanced cancer patients undergoing chemotherapy | Ferric gluconate (125 mg i.v. weekly) or lactoferrin (200 mg/day) | Efficacy and safety of oral lactoferrin supplementation in combination with rHuEPO-beta for the treatment of anemia in advanced cancer patients undergoing chemotherapy: open-label, randomized controlled study.cited 48× |
| switch from oral iron to intravenous ferric carboxymaltose | Increases - improve | hemoglobin | Human | patients with ND-CKD | 1,000 mg iron (initial dose), followed by a 6-month maintenance regimen. | Switching patients with non-dialysis chronic kidney disease from oral iron to intravenous ferric carboxymaltose: effects on erythropoiesis-stimulating agent requirements, costs, hemoglobin and iron status.cited 14× |
| Oral iron | No effect - insufficient and slow to improve | hemoglobin concentrations | Human | patients with chronic kidney disease (CKD) | Not specified | Anemia in Peritoneal Dialysis Patients; Iron Repletion, Current and Future Therapies.cited 10× |
| oral iron and folate supplementation | No effect - received | hemoglobin (Hb) >139 g.L(-1), aged >70 yr and weighed < 70 kg | Human | protocol subjects | Oral iron and folate supplementation (specific dosage not mentioned). | Allogeneic blood transfusion reduction by risk-based protocol in total joint arthroplasty.cited 8× |
| iron supplementation and multivitamins (vitamins A, C, and D) | Increases - was associated with greater increases in | hemoglobin concentrations | Human | HIV-infected Malawian children aged 6-59 months with moderate anemia | 3 mg/kg/day of elemental iron with multivitamins (vitamins A, C, and D). | Iron supplementation in HIV-infected Malawian children with anemia: a double-blind, randomized, controlled trial.cited 47× |
| iron formula | Increases - gained | circulating hemoglobin | Human | the intervention group | 30-day oral therapy of sucrosomial ferric pyrophosphate plus L-ascorbic acid (specific dosage not provided). | Oral Supplementation with Sucrosomial Ferric Pyrophosphate Plus L-Ascorbic Acid to Ameliorate the Martial Status: A Randomized Controlled Trial.cited 17× |
| direct observation of oral iron supplementation | Increases - increased | blood hemoglobin level | Human | — | Not specified | Directly observed iron supplementation for control of iron deficiency anemia.cited 9× |
| iron sucrose 100 mg IV | No effect - no significant difference | hemoglobin concentration | Human | anemic, critically ill trauma patients | 100 mg IV iron sucrose thrice weekly | A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness*.cited 68× |
| folic acid and iron | No effect - were not different | Hemoglobin levels | Human | Non-pregnant women and adolescent girls aged 15-29 years | Folic acid, iron, and vitamins A, B-complex, C, and E at approximately single recommended dietary allowance (RDA) doses, administered daily. | Multivitamin and iron supplementation to prevent periconceptional anemia in rural tanzanian women: a randomized, controlled trial.cited 20× |
| addition of iron to ESAs | Increases - improvement | hemoglobin (Hb) levels | Human | people with chemotherapy-induced anemia | Not specified in the abstract. | The role of iron in the management of chemotherapy-induced anemia in cancer patients receiving erythropoiesis-stimulating agents.cited 41× |
| Addition of iron to ESAs | Increases - increases | hemoglobin levels | Human | — | Not specified | Iron Supplementation for Chemotherapy-Induced Anemia in Patients Receiving Erythropoiesis-Stimulating Agents.cited 4× |
| body iron | No effect - mainly serves to synthesize | hemoglobin for new red blood cells | Human | — | Not specified | The Central Role of Iron in Human Nutrition: From Folk to Contemporary Medicine.cited 34× |
| iron therapy twice daily | Increases - showed significant improvement | hemoglobin levels | Human | female participants aged 18-45 years with hemoglobin < 10 g/dL and serum ferritin < 20 ng/ml | Every other day, once daily, or twice daily iron therapy (specific iron compound and dosage not specified). | Effects of Different Doses of Oral Iron on Hepcidin and Treatment Response in Iron Deficiency Anemia.cited 1× |
| Double-fortified salt (DFS) containing iron and iodine | Increases - increased | hemoglobin concentrations | Human | effectiveness studies | Not specified | Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis.cited 27× |
| Double-fortified salt (DFS) containing iron and iodine | Increases - increased | hemoglobin concentrations | Human | school-age children | Not specified | Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis.cited 27× |
| Double-fortified salt (DFS) containing iron and iodine | Increases - efficacious in increasing | hemoglobin concentrations | Human | LMIC populations | Not specified | Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis.cited 27× |
| Double-fortified salt (DFS) containing iron and iodine | Increases - increased | hemoglobin concentrations | Human | efficacy studies | Not specified | Impact of Double-Fortified Salt with Iron and Iodine on Hemoglobin, Anemia, and Iron Deficiency Anemia: A Systematic Review and Meta-Analysis.cited 27× |
| daily iron (300 mg ferrous sulfate) + 0.40 mg folate | Increases - was significantly higher | maternal hemoglobin | Human | women at or near term | 300 mg ferrous sulfate + 0.40 mg folate daily. | Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates.cited 56× |
| total dose infusion (TDI) of low-molecular weight (LMW) iron dextran | Increases - improved significantly more | mean corpuscular hemoglobin (MCH) | Human | cases with iron deficiency anemia in the second and third trimester of pregnancy | 100 mg lactoferrin oral sachets twice daily; total dose infusion of low-molecular weight iron dextran (specific dosage not detailed). | Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial.cited 5× |
| enteral iron supplementation | Increases - resulted in increased | hemoglobin concentrations | Human | preterm and low-birth-weight infants | Not specified | Iron supplementation in preterm and low-birth-weight infants: a systematic review of intervention studies.cited 43× |
| daily supplementation with 60 mg of elemental iron | Increases - yielded the following results at 1 month after birth: maternal hemoglobin concentration: 12.89 g/dL vs 11.99 g/dL | maternal hemoglobin concentration | Human | women who received iron vs placebo | 60 mg elemental iron (as ferrous fumarate) daily. | Effect of Daily Antenatal Iron Supplementation on Plasmodium Infection in Kenyan Women: A Randomized Clinical Trial.cited 58× |
| oral iron treatment | No effect - lack of effect on | iron stores measured by hemoglobin | Human | patients with heart failure and iron deficiency | Not specified in the abstract. | Effects and Safety of Oral Iron for Heart Failure with Iron Deficiency: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.cited 1× |
| Antarctic krill peptide-iron complex | Increases - significantly increased | hemoglobin (Hb) | Animal | iron-deficiency anemia (IDA) mice | — | Iron Complexes with Antarctic Krill-Derived Peptides Show Superior Effectiveness to Their Original Protein-Iron Complexes in Mice with Iron Deficiency Anemia. |
| directly observed home-based daily iron therapy | Increases - higher hemoglobin rise | hemoglobin | Human | anemic women and adolescent girls | Not specified in the abstract. | A community-based cluster randomized controlled trial of "directly observed home-based daily iron therapy" in lowering prevalence of anemia in rural women and adolescent girls.cited 8× |
| iron supplements at a dose of 0 (placebo), 1, or 2 mg/kg per day between 6 weeks and 6 months of age | Increases - resulted in significant dose-dependent effects on | hemoglobin and all iron status indicators | Human | MLBW infants | 0 (placebo), 1, or 2 mg/kg per day. | Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants.cited 82× |
| daily oral iron supplementation | No effect - had no significant effect | hemoglobin level | Human | exclusively breastfed infants | Not specified | Effect of Daily Iron Supplementation in Healthy Exclusively Breastfed Infants: A Systematic Review with Meta-Analysis.cited 13× |
| monthly infusions of disodium calcium edetate and oral iron compounds | Decreases - resulted in decreased | hemoglobin levels | Human | 10-year-old boy with SLC30A10 mutation | Not applicable | A case of dystonia with polycythemia and hypermanganesemia caused by SLC30A10 mutation: a treatable inborn error of manganese metabolism.cited 12× |
| preoperative IV iron therapy | Increases - may have an earlier and more robust hemoglobin recovery | hemoglobin recovery | Human | Patients with preoperative iron deficiency anemia | Not specified | Efficacy and safety of erythropoietin and intravenous iron in perioperative blood management: a systematic review.cited 69× |
| preoperative IV iron therapy | Increases - may have an earlier and more robust hemoglobin recovery | hemoglobin recovery | Human | Patients with preoperative iron deficiency anemia | Not specified | Efficacy and safety of erythropoietin and intravenous iron in perioperative blood management: a systematic review.cited 69× |
| 12.5 mg elemental iron once daily | Increases - effective in increasing | hemoglobin levels | Human | infants aged 12-24 months | 25 mg elemental iron once weekly (Group A); 12.5 mg elemental iron once daily (Group B). | Daily and Weekly Iron Supplementations are Effective in Increasing Hemoglobin and Reducing Anemia in Infants.cited 5× |
| 25 mg elemental iron once weekly | Increases - effective in increasing | hemoglobin levels | Human | infants aged 12-24 months | 25 mg elemental iron once weekly (Group A); 12.5 mg elemental iron once daily (Group B). | Daily and Weekly Iron Supplementations are Effective in Increasing Hemoglobin and Reducing Anemia in Infants.cited 5× |
| IV iron | Increases - demonstrated a higher efficacy in achieving | hemoglobin rise of ≥2.0 g/dL | Human | IBD patients | Not specified in the abstract. | Intravenous Versus Oral Iron for the Treatment of Anemia in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.cited 73× |
| Sucrosomial iron | Increases - increased | hemoglobin | Animal | msk/msk mice | — | Iron distribution in different tissues of homozygous Mask (msk/msk) mice and the effects of oral iron treatments. |
| Sucrosomial iron | Increases - minor increase | hemoglobin | Animal | msk/msk mice | — | Iron distribution in different tissues of homozygous Mask (msk/msk) mice and the effects of oral iron treatments. |
| Sucrosomial iron | Increases - corrected | hemoglobin levels | Animal | anemic control mice | — | Iron distribution in different tissues of homozygous Mask (msk/msk) mice and the effects of oral iron treatments. |
| Sucrosomial iron | Increases - significantly increased | hemoglobin levels | Human | subjects with hemoglobin between 7-10 g/dl | Not specified in the abstract. | Comparative evaluation of different oral iron salts in the management of iron deficiency anemia. |
| Sucrosomial iron | Increases - showed significantly higher improvement | hemoglobin levels | Human | subjects with hemoglobin between 7-10 g/dl | Not specified in the abstract. | Comparative evaluation of different oral iron salts in the management of iron deficiency anemia. |
| community-based weekly iron-folic acid supplementation (WIFAS) | Increases - was associated with an improvement of | hemoglobin concentration | Human | adolescent girls | Weekly iron-folic acid supplementation (specific dosage not mentioned in the abstract). | A community-based randomized controlled trial providing weekly iron-folic acid supplementation increased serum- ferritin, -folate and hemoglobin concentration of adolescent girls in southern Ethiopia.cited 12× |
| administration of injectable preparations of recombinant erythropoiesis-stimulating agents (ESAs), especially epoetin and darbepoetin, coupled with oral or intravenous(iv) iron supplementation | Increases - ensuring the achievement of | optimal hemoglobin target levels | Human | dialysis and non-dialysis patients with anemia in CKD | Not specified | Hypoxia-Inducible Factor Stabilizers in End Stage Kidney Disease: "Can the Promise Be Kept?".cited 11× |
| high-dose iron | Decreases - was significantly decreased | The required rhEPO dosage (mg/week) to maintain hemoglobin levels between 10 and 12 g/dL | Human | patients under hemodialysis | Low dose (100 mg/week) and high dose (400 mg/week) of intravenous iron. | The Impact of Intravenous Iron Supplementation on Hematinic Parameters and Erythropoietin Requirements in Hemodialysis Patients.cited 2× |
| >Your< Iron Syrup | Increases - resulted in a significant increase | hemoglobin levels | Human | healthy children with iron deficiency | Not available | Micronized, Microencapsulated Ferric Iron Supplementation in the Form of >Your< Iron Syrup Improves Hemoglobin and Ferritin Levels in Iron-Deficient Children: Double-Blind, Randomized Clinical Study of Efficacy and Safety.cited 3× |
| multiple micronutrient powders (MNPs) containing iron | Increases - was associated with an improvement | hemoglobin levels | Human | children aged 6-11 months in rural China | Daily MNP sachets (specific iron dosage not mentioned). | The effect of a micronutrient powder home fortification program on anemia and cognitive outcomes among young children in rural China: a cluster randomized trial.cited 25× |
| multiple micronutrient powders (MNPs) containing iron | Increases - modestly hastened improvement | hemoglobin levels | Human | children aged 6-11 months in rural China | Daily MNP sachets (specific iron dosage not mentioned). | The effect of a micronutrient powder home fortification program on anemia and cognitive outcomes among young children in rural China: a cluster randomized trial.cited 25× |
| daily supplements of 10 mg of iron and 0.5 mg of copper with or without 10 mg of zinc | Increases - increased significantly | hemoglobin concentrations | Human | non-anemic Peruvian infants | 0.5 mg of copper daily. | Mineral status of non-anemic Peruvian infants taking an iron and copper syrup with or without zinc from 6 to 18 months of age: a randomized controlled trial.cited 8× |
| delayed iron supplementation | No effect - did not differ | concentrations of hemoglobin | Human | children aged 6-59 mo with malaria and hemoglobin concentrations of 50.0-99.9 g/L | Not specified in the abstract. | Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial.cited 17× |
| delayed iron supplementation | Decreases - reflected poorer iron status | hemoglobin | Human | children aged 6-59 mo with malaria and hemoglobin concentrations of 50.0-99.9 g/L | Not specified in the abstract. | Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial.cited 17× |