Correlation of rheological parameters in maternal and fetal blood at term.
Study Goal
The researchers aimed to investigate the association between maternal and fetal blood rheology, including the impact of maternal iron supplementation on fetal blood parameters.
Results Summary
Iron supplementation during pregnancy increased fetal hemoglobin, hematocrit, and erythrocyte aggregation but did not significantly affect neonatal plasma viscosity. Maternal smoking was associated with higher plasma viscosity and erythrocyte aggregation in neonates.
Population
4985 consecutive mothers and their newborns at delivery.
Effective Dosage
Not specified
Duration
Duration of iron supplementation not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
- | no change | maternal and newborn plasma viscosity | mothers and newborns | r = 0.2; p < 0.0001 | correlated statistically significant | #1 |
- | increase | fetal plasma viscosity | fetus | r = 0.197; p < 0.001 | remarkable correlation | #2 |
Iron supplementation during pregnancy | increase | fetal hemoglobin | fetus | p < 0.0001 | led to increased | #3 |
Iron supplementation during pregnancy | increase | fetal hematocrit | fetus | p < 0.0001 | led to increased | #4 |
Iron supplementation during pregnancy | increase | fetal erythrocyte aggregation stasis | fetus | p < 0.0001 | led to increased | #5 |
Iron supplementation during pregnancy | increase | fetal erythrocyte aggregation low shear | fetus | p < 0.0001 | led to increased | #6 |
Iron supplementation during pregnancy | no change | neonatal plasma viscosity | neonates | p = 0.068 | did not have a significant impact | #7 |
Smoking | increase | neonatal plasma viscosity | neonates | p = 0.049 | gave birth to neonates with significantly higher | #8 |
Smoking | increase | neonatal erythrocyte aggregation stasis | neonates | p = 0.016 | gave birth to neonates with significantly higher | #9 |
Smoking | increase | neonatal erythrocyte aggregation low shear | neonates | p = 0.013 | gave birth to neonates with significantly higher | #10 |
OBJECTIVE: An association between maternal and fetal blood rheology has not yet been investigated nor is it known whether and to what extent fetal blood rheology may be affected by maternal conditions. METHODS: At delivery, blood was drawn from the cubital vein of 4985 consecutive mothers and from the umbilical cord during birth for determination of blood rheological parameters (erythrocyte aggregation stasis [E0], low shear [E1], plasma viscosity [Pv]) in addition to hemoglobin (Hb) values and hematocrit (Hct). RESULTS: Maternal and newborn Pv (r = 0.2; p < 0.0001) correlated statistically significant. There was a remarkable correlation between fetal Pv and gestational age (r = 0.197; p < 0.001). Iron supplementation during pregnancy led to increased fetal Hb, Hct as well as E0 and E1 (p < 0.0001), did not have a significant impact on neonatal Pv (p = 0.068). Smoking mothers gave birth to neonates with significantly higher Pv (p = 0.049), E0 (p = 0.016) and E1 (p = 0.013). CONCLUSIONS: The increase of fetal plasma viscosity at advanced delivery time-points refers to a more gaining protein synthesis by the fetal liver and thus maturity of the fetus. Iron supplementation as well as smoking during pregnancy is associated with a relative hyper-viscosity in the fetus at delivery.