PREECLAMPSIA AND IRON EXCHANGE. ARE THERE ANY COMMON PATTERNS?
Study Goal
The researchers aimed to determine the correlation between serum iron and hemoglobin levels with clinical symptoms of preeclampsia in pregnant women.
Results Summary
The study found a direct correlation between serum iron levels and blood pressure, as well as between endothelin-1 and both total hemoglobin and serum iron concentrations, suggesting iron's role in preeclampsia pathogenesis.
Population
Nulliparous women with moderate or severe preeclampsia (30-39 weeks gestation) and healthy non-pregnant women as controls.
Effective Dosage
Not specified (iron supplementation was given when total hemoglobin was < 115 g/l).
Duration
Not specified (measurements taken before and 2 hours after delivery).
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
iron supplementation | decrease | total hemoglobin | nulliparous women with preeclampsia moderate degree and severe degree | < 115 g/l | was a condition for inclusion | #1 |
- | increase | serum iron level | women with preeclampsia | r = 0.5412 and r = 0.6229 | has a direct correlation | #2 |
- | increase | endothelin-1 | women with preeclampsia | r = 0.6446 | has a direct correlation | #3 |
- | increase | endothelin-1 | women with preeclampsia | r = 0.7841 | has a direct correlation | #4 |
THE AIM: Detarmination of correlation between the level ofserm iron and hemoglobin with clinical symptoms ofpreeclampsia. MATERIALS AND METHODS: A prospective randomized controlled investigation of 62 women in the gestation of 30 to 39 weeks. Women were divided into 2 main groups. The first group included 38 nulliparous women with preeclampsia moderate degree (Io group) gestational age from 30 to 39 weeks, at the age of 26,8±2,7 years. The second main group included 24 nulliparous women with preeclampsia severe degree (II group) in gestational age from 30 to 39 weeks of similar age. The conditionfor inclusion in the main groups was iron supplementation in the period of total hemoglobin reducing < 115 g/l. The first control group (I) included 26 nulliparous women average 26,2±1,6 years, which admitted to a maternity hospital for planned Cesarean section. The second group (IQ included 22 healthy non-pregnant women at the age of 25,8±4,4 years. During hospitalization, before delivery and at 2 hours after delivery was investigated the concentration of total hemoglobin, serum iron, total bilirubin, creatinine, urea, endothelin-1 (immediately before delivery and after delivery). The total analyses of urine examined the number of red blood cells and white blood cells and protein concentration. RESULTS: It''s revealed that the serum iron level has a direct correlation with the level of blood preasure (r = 0,5412 and r = 0,6229) and concentration of endothelin- with total hemoglobin (r = 0,6446 in p < 0,03) and with serum iron concentration (r = 0,7841 in p < 0,02). Conclusuion. The analysis of conducted investigation allows to approve about the pathogenetic importance of iron in the development ofpreeclampsia and post-partum complications, that require new approaches of iron during gestation.