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Evidence suggests Vitamin D mayincreaseMetabolism.
82 studies (36 claims)
Emerging evidence
Typical effective dose 2800 (1900–3900) IUacross 3 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| vitamin D supplementation | Decreases - may help prevent | alterations in bone metabolism | Human | children newly diagnosed with partial epilepsy | Not specified | Effect of carbamazepine therapy on vitamin D and parathormone in epileptic children.cited 31× |
| vitamin D supplementation | No effect - has a significant impact on | bone metabolism | Human | — | Not specified | Vitamin D: Analytical Advances, Clinical Impact, and Ongoing Debates on Health Perspectives.cited 8× |
| vitamin D supplementation | No effect - plays a key role | calcium and phosphate metabolism | Human | — | 400 IU/day for infants; supplementation beyond 1 year for high-risk groups. | Vitamin D in the healthy European paediatric population.cited 316× |
| vitamin D supplementation | No effect - would alter | circulating long-chain ceramides and related metabolites involved in sphingolipid metabolism | Human | humans | 600, 2000, or 4000 IU/day of vitamin D. | Vitamin Dcited 12× |
| vitamin D supplementation | No effect - would alter | circulating long-chain ceramides and related metabolites involved in sphingolipid metabolism | Human | overweight/obese African-Americans | 600, 2000, or 4000 IU/day of vitamin D. | Vitamin Dcited 12× |
| Vitamin D supplementation | Increases - demonstrated improvements | glucose metabolism | Human | people | Not specified | The Role of Vitamin D and Its Molecular Bases in Insulin Resistance, Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the Art.cited 53× |
| Vitamin D supplementation | Increases - demonstrated improvements | lipid metabolism | Human | people | Not specified | The Role of Vitamin D and Its Molecular Bases in Insulin Resistance, Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the Art.cited 53× |
| vitamin D supplementation | No effect - effect | glucose metabolism | HumanAnimal | prediabetic participants | 1600 IU/day. | Vitamin Dcited 4× |
| vitamin D supplementation | No effect - effect | glucose metabolism | HumanAnimal | mice | 1600 IU/day. | Vitamin Dcited 4× |
| vitamin D supplementation | Increases - demonstrating improvements | insulin sensitivity, glucose and lipid metabolism | Human | humans | Not specified | Vitamin D, sub-inflammation and insulin resistance. A window on a potential role for the interaction between bone and glucose metabolism.cited 93× |
| Vitamin D supplementation | Increases - has beneficial effects on | lipid metabolism | Human | — | Not specified | Vitamin D and Polycystic Ovary Syndrome: a Narrative Review.cited 32× |
| Vitamin D supplementation | Increases - improves | maternal glucose metabolism | Human | pregnant women | Not specified | Vitamin D and gestational diabetes: an update.cited 26× |
| vitamin D supplementation | No effect - will be assessed for effectiveness | serum parameters of calcium phosphorus metabolism | Human | preterm infants | 500 IU plus 150-300 IU/kg in human milk fortifiers or 190 IU/kg in milk formulas. | MOnitored supplementation of VItamin D in preterm infants (MOSVID trial): study protocol for a randomised controlled trial.cited 11× |
| Vitamin D supplementation | Decreases - can reduce | the negative impact on other markers of bone mineral metabolism | Human | children, 2-12 y of age with newly diagnosed epilepsy, and vitamin D sufficient status, and started on valproate monotherapy | 600 IU vitamin D daily | Effect of Daily Vitamin D Supplementation on Serum Vitamin D Levels in Children with Epilepsy Receiving Sodium Valproate Monotherapy: A Randomized, Controlled Trial.cited 7× |
| vitamin D supplementation | No effect - no treatment effect | various parameters of bone metabolism | Human | participants with functional vitamin D deficiency | 2,800 international units of vitamin D per day. | Classification of Vitamin D Status Based on Vitamin D Metabolism: A Randomized Controlled Trial in Hypertensive Patients.cited 2× |
| vitamin D supplementation | Increases - treatment effects often noted only in | vitamin D metabolism | Human | the most deficient women | 400 IU/day for infants; 6,400 IU/day for mothers. | Early-Life Effects of Vitamin D: A Focus on Pregnancy and Lactation.cited 28× |
| 40 μg (1,600 IU) per day of vitamin D(3) | No effect - was evaluated | serum 25-hydroxyvitamin D (25(OH)D) and markers of bone and mineral metabolism | Human | community-dwelling subjects (32 females), age 55-84 years, at 58° North latitude | 1,000 mg calcium per day. | Is a daily supplementation with 40 microgram vitamin D3 sufficient? A randomised controlled trial.cited 13× |
| native vitamin D supplementation | Increases - minimal and varied benefit | outcomes beyond mineral metabolism | Human | patients with ESKD | Not specified | Does Native Vitamin D Supplementation Have Pleiotropic Effects in Patients with End-Stage Kidney Disease? A Systematic Review of Randomized Trials.cited 3× |
| Increasing dietary intake of calcium and vitamin D | Increases - appears to be effective in producing favorable changes | several bone metabolism and bone mass indices | Human | osteopenic postmenopausal women | 1,200 mg calcium and 7.5 μg vitamin D3 (first 12 months), increased to 22.5 μg vitamin D3 (remaining 18 months), delivered via fortified dairy products. | Calcium and vitamin D supplementation through fortified dairy products counterbalances seasonal variations of bone metabolism indices: the Postmenopausal Health Study.cited 18× |
| Vitamin D | No effect - is an important factor influencing | bone and calcium metabolism | Human | — | Not specified | Effects of Vitamin D on Cardiovascular Risk and Oxidative Stress.cited 53× |
| Vitamin D | No effect - has been appreciated beyond | bone health and calcium metabolism | Human | — | Not specified | Vitamin D and Respiratory Diseases : Based on 11th Dr. I. C. Verma Excellence in Research Award for Young Pediatricians Delivered as Oration on 15th Oct. 2023. |
| vitamin D | No effect - control | bone metabolism | Human | — | Not mentioned | Novel roles of vitamin D in disease: what is new in 2011?cited 73× |
| vitamin D | Increases - may benefit | bone metabolism | Human | — | — | Editorial Commentary: Testosterone, Growth Hormone, and Vitamin D Supplementation Is Not Routinely Indicated for Orthopaedic Surgery Patients. |
| vitamin D | No effect - important in | bone metabolism | Human | — | Not specified | Vitamin D in Foot and Ankle Fracture Healing: A Literature Review and Research Design.cited 2× |
| vitamin D | No effect - plays a key role in | bone metabolism | Human | — | Not specified | Vitamin D and Bone fragility in Individuals with Osteogenesis Imperfecta: A Scoping Review.cited 5× |
| vitamin D | No effect - well-established effects on | bone metabolism | Human | — | Not specified | A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research.cited 1× |
| Vitamin D | No effect - plays an important role | bone metabolism | Human | — | Not mentioned. | The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health.cited 124× |
| vitamin D | No effect - has a profound effect on | calcium and bone metabolism | Human | — | Not specified | Vitamin D efficacy in type 1 and type 2 diabetes.cited 3× |
| Vitamin D | No effect - has well-established roles | calcium and bone metabolism | Human | — | — | Vitamin D and systemic lupus erythematosus: continued evolution.cited 28× |
| vitamin D | No effect - well known for its effects | calcium and mineral metabolism | Human | — | 20,000 IU of vitamin D3 per week. | Effects of Vitamin D Supplementation on Bone Turnover and Bone Mineral Density in Healthy Men: A Post-Hoc Analysis of a Randomized Controlled Trial.cited 17× |
| Vitamin D | No effect - regulates | calcium and phosphate metabolism | Human | — | — | Vitamin D: a new player in kidney transplantation?cited 13× |
| Vitamin D | No effect - plays a vital role in regulating | calcium and phosphate metabolism | Human | — | Not specified | Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention.cited 8× |
| Vitamin D | No effect - regulating | calcium and phosphate metabolism | Human | — | Not mentioned | Recent Updates and Advances in the Association Between Vitamin D Deficiency and Risk of Thrombotic Disease.cited 2× |
| Vitamin D | No effect - intervenes in | calcium and phosphate metabolism and bone homeostasis | HumanMolecular | — | Not specified (recommended serum levels: 30-60 ng/mL). | An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases.cited 126× |
| Vitamin D | No effect - is an immunomodulatory hormone with an established role | calcium and phosphate metabolism and skeletal mineralization | Human | — | Not specified | Vitamin D deficiency: concern for rheumatoid arthritis and COVID-19?cited 3× |
| Vitamin D | No effect - plays an essential role | calcium homeostasis and bone metabolism | HumanAnimalMolecular | — | Not specified | Vitamin D and vitamin D receptor activators in treatment of hypertension and cardiovascular disease.cited 28× |
| vitamin D | No effect - extend far beyond the control | calcium metabolism | Human | — | Not mentioned. | Vitamin D and cardiovascular prevention.cited 23× |
| vitamin D | No effect - has a role in | calcium metabolism | Human | — | Not specified | Therapeutic use of vitamin D and its analogues in autoimmunity.cited 15× |
| vitamin D | No effect - has an undisputed role | calcium metabolism | Human | — | Not specified | Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus.cited 87× |
| vitamin D | No effect - involved primarily in | calcium metabolism | Human | — | Not specified | Vitamin D and Ovarian Cancer: Systematic Review of the Literature with a Focus on Molecular Mechanisms.cited 21× |
| vitamin D | No effect - has important roles in | calcium metabolism | Human | — | Not specified | Vitamin D, and Maternal and Child Health.cited 26× |
| Vitamin D | No effect - maintaining optimal health | calcium metabolism and skeletal health | Human | — | Not specified | Vitamin D and health in the Mediterranean countries.cited 12× |
| vitamin D | Increases - has some well-known effects | calcium, phosphate and bone metabolism | Human | — | Not specified | Vitamin D and rheumatic diseases.cited 9× |
| vitamin D | No effect - plays a pivotal role in the regulation | calcium-phosphorus metabolism | Human | pediatric age | Not specified | Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians.cited 134× |
| Vitamin D | Increases - influences the cell metabolism and maintenance specific nuclear programs | cell metabolism and maintenance specific nuclear programs | Human | — | Not specified | The Role of Vitamin D in SARS-CoV-2 Infection and Acute Kidney Injury.cited 7× |
| vitamin D | No effect - caused alterations in choline metabolism | choline metabolism | Human | — | Not specified for betaine (study used 0.5 mg folic acid, 50 mg B6, and 0.5 mg B12 alongside 1200 IU vitamin D3 and 800 mg calcium) | Plasma trimethylamine-N-oxide following supplementation with vitamin D or D plus B vitamins.cited 22× |
| Vitamin D | No effect - plays an important role in the development and maintenance of the skeleton, as well as bone and cartilage metabolism | development and maintenance of the skeleton, bone and cartilage metabolism | Human | — | Not specified | Role of Fat-Soluble Vitamins in Osteoarthritis Management.cited 10× |
| Vitamin D | No effect - is involved in the regulation of | energetic metabolism | Human | — | Not specified | Vitamin D supplementation in cancer prevention and the management of cancer therapy.cited 1× |
| vitamin D | No effect - effects are inconclusive | energy metabolism | Human | human adipose tissue | Not specified | Vitamin D and Visceral Obesity in Humans: What Should Clinicians Know?cited 19× |
| vitamin D | No effect - exerts important pleiotropic effects | extracellular calcium homeostasis and bone metabolism | Human | — | — | The role of vitamin D for cardiovascular disease and overall mortality.cited 28× |
| vitamin D | No effect - associated with activation mechanisms of transcription factors related to genes of the glucide metabolism and the insulin receptor | genes of the glucide metabolism and the insulin receptor | Human | — | Not specified. | Molecular mechanisms from insulin-mimetic effect of vitamin D: treatment alternative in Type 2 diabetes mellitus.cited 10× |
| vitamin D | No effect - involvement in | glucose metabolism and cardiovascular system | Human | — | Maintain serum 25(OH)D of at least 30 ng/mL (preferred range 40-60 ng/mL). | Association of vitamin D status with COVID-19 and its severity : Vitamin D and COVID-19: a narrative review.cited 43× |
| vitamin D | No effect - had no positive effects in ameliorating | glycolipid metabolism profiles | Human | women with PCOS | Not specified | The effectiveness of coenzyme Q10, vitamin E, inositols, and vitamin D in improving the endocrine and metabolic profiles in women with polycystic ovary syndrome: a network Meta-analysis.cited 15× |
| vitamin D | No effect - involved in | lipid metabolism | Human | — | Not specified | Links between Vitamin D Deficiency and Cardiovascular Diseases.cited 167× |
| vitamin D | No effect - plays an important role in | regulation of calcium and phosphorus metabolism | Human | human body | Not mentioned | Roles of Vitamin D in Reproductive Systems and Assisted Reproductive Technology.cited 22× |
| vitamin D | No effect - plays an essential role in the regulation | skeletal metabolism | Human | — | Not mentioned | A therapeutic role for vitamin D on obesity-associated inflammation and weight-loss intervention.cited 32× |
| Magnesium combined with vitamin E or zinc-calcium-vitamin D | Increases - significantly improved | glucose and lipid metabolism | Human | PCOS patients | — | The effect of magnesium alone or its combination with other supplements on the markers of inflammation, OS and metabolism in women with polycystic ovarian syndrome (PCOS): A systematic review.cited 5× |
| daily vitamin D dose of 4000 IU (moderately high dose) for 3 years | No effect - had no effect | parameters of bone metabolism | Human | patients with heart failure | 4000 IU daily | Vitamin D supplementation and bone turnover in advanced heart failure: the EVITA trial.cited 8× |
| daily vitamin D dose of 4000 IU (moderately high dose) for 3 years | No effect - had no effect | parameters of bone metabolism | Human | patients with very low vitamin D status | 4000 IU daily | Vitamin D supplementation and bone turnover in advanced heart failure: the EVITA trial.cited 8× |
| Nutritional intervention with olive oil, vitamin D and omega-3 fatty acids | No effect - targeting genes involved | genes involved in fatty acid metabolism and transposable elements in the sperm genome | Human | participants enrolled in the PREPARE trial | Not specified | Short-term diet intervention comprising of olive oil, vitamin D, and omega-3 fatty acids alters the small non-coding RNA (sncRNA) landscape of human sperm. |
| magnesium-zinc-calcium-vitamin D co-supplementation | No effect - had beneficial effects | insulin metabolism | Human | patients with PCOS | 100 mg magnesium, 4 mg zinc, 400 mg calcium, and 200 IU vitamin D twice daily | A Trial on The Effects of Magnesium-Zinc-Calcium-Vitamin D Co-Supplementation on Glycemic Control and Markers of Cardio-Metabolic Risk in Women with Polycystic Ovary Syndrome.cited 15× |
| oral vitamin D supplementation | Increases - can favor the state of | iron metabolism | Human | athlete with a deficiency | 3000 IU/day of vitamin D3. | Effects of Vitamin D Supplementation on Haematological Values and Muscle Recovery in Elite Male Traditional Rowers.cited 29× |
| supplementation of vitamin D or estrogen | No effect - should be considered in the treatment | impaired calcium metabolism | Human | individuals with frequent recurrences of BPPV | Not specified | Impaired Calcium Metabolism in Benign Paroxysmal Positional Vertigo: A Topical Review.cited 31× |
| vitamin D-fortified yogurt | Increases - may be beneficial in improving | glucose metabolism | Human | pregnant women and adult and elderly subjects with or without diabetes, prediabetes, or metabolic syndrome | Vitamin D fortification ranged from 400 to 2,000 IU; calcium dosage not specified. | Is vitamin D-fortified yogurt a value-added strategy for improving human health? A systematic review and meta-analysis of randomized trials.cited 18× |
| vitamin D treatment | No effect - did not change | markers of bone metabolism | Human | postmenopausal women | 400 IU or 1000 IU vitamin D3 daily. | Hip bone loss is attenuated with 1000 IU but not 400 IU daily vitamin D3: a 1-year double-blind RCT in postmenopausal women.cited 48× |
| routine supplementation of calcium and vitamin D | No effect - is not likely sufficient to compensate | obesity-associated deficiencies in bone metabolism | Human | — | — | Markers of Bone Metabolism in Obese Individuals Undergoing Laparoscopic Sleeve Gastrectomy.cited 17× |
| nutritional vitamin D | Increases - achieve mineral-bone metabolism balance | mineral-bone metabolism balance | Human | human body | Not specified | Mini review: A reevaluation of nutritional vitamin D in the treatment of chronic kidney disease.cited 1× |
| vitamin D deficiency | Increases - is plausibly implicated in | adverse health outcomes including mortality, malignancy, cardiovascular disease, immune functioning and glucose metabolism | Human | human | Not specified | Vitamin D and pregnancy: An old problem revisited.cited 70× |
| vitamin D deficiency | No effect - underlying mechanisms of effect on | glucose metabolism | Human | women during pregnancy | Not specified | Vitamin D in gestational diabetes: A broadened frontier.cited 9× |
| vitamin D deficiency | No effect - is better characterized in | situations that involve the musculoskeletal system and bone metabolism | Human | — | Not specified | Is there an association between vitamin D and hypertension?cited 8× |
| vitamin D status | No effect - does not affect | energy metabolism | Human | young, healthy, non-obese adults | Not mentioned | 25-Hydroxyvitamin D status does not affect energy metabolism among young, healthy, non-obese adults: a metabolic chamber study. |
| conventional approaches of restricting dietary phosphate, administering phosphate binders, and use of active vitamin D and calcimimetics | No effect - remains controversial | control of mineral metabolism | Human | patients with CKD | Not specified | Current and potential therapeutic strategies for the management of vascular calcification in patients with chronic kidney disease including those on dialysis.cited 37× |
| Sarcomeal® supplement plus vitamin D | Decreases - reducing | glucose metabolism | Human | diabetic people who also have sarcopenia | 1000 IU of vitamin D daily. | The effect of Sarcomeal® oral supplementation plus vitamin D3 on muscle parameters and metabolic factors in diabetic sarcopenia patients: study protocol of a randomized controlled clinical trial. |
| novel vitamin D analogues | Decreases - with more pronounced immune modulatory effect and lower activity on calcium metabolism | activity on calcium metabolism | HumanMolecular | autoimmune disorders | Not specified | Vitamin D levels and potential impact in systemic sclerosis.cited 24× |
| Combined supplementation with vitamin D and omega-3 fatty acids | Increases - effectively improve | glucose and lipid metabolism | Human | patients with GDM | 40,000 IU of vitamin D and 8,000 mg of omega-3 fatty acids twice daily. | The effect of combined supplementation with vitamin D and omega-3 fatty acids on blood glucose and blood lipid levels in patients with gestational diabetes.cited 10× |
| active hormonal vitamin D | Decreases - could counteract | harmful effects of obesity on metabolism | Human | — | Not specified | Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities.cited 52× |
| vitamin D supplementation during pregnancy for at least three months before delivery | Increases - has the potential of positively influencing | calcium metabolism | Human | newborns and infants | 23 different doses, regimens, and times of use (specific amounts not detailed in abstract). | EFFECTS OF VITAMIN D SUPPLEMENTATION DURING PREGNANCY ON NEWBORNS AND INFANTS: AN INTEGRATIVE REVIEW.cited 3× |
| combined treatment with vitamin D and beta-glucans | Increases - enhanced | changes in energy metabolism | HumanMolecular | human macrophages | 100 µg/mL beta-glucans | Vitamin D and Beta-Glucans Synergically Stimulate Human Macrophage Activity.cited 8× |
| addition of collagen peptides (CPs) in a calcium and vitamin D supplement | Increases - may enhance its already known positive effect | bone metabolism | Human | — | Group A: 500 mg elemental calcium (as calcium lactate), 400 IU vitamin D3, and 5 g CPs daily; Group B: 500 mg elemental calcium (as calcium carbonate) and 400 IU vitamin D3 daily. | Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia.cited 8× |
| high doses of vitamin D supplementation | No effect - investigate the effects | parameters of Hcy metabolism and cytokines in sera | Human | psoriatic patients | 5000 IU/day | The Effect of Three-Month Vitamin D Supplementation on the Levels of Homocysteine Metabolism Markers and Inflammatory Cytokines in Sera of Psoriatic Patients.cited 14× |
| administration of vitamin D metabolites | Decreases - Management of heritable types of rickets associated with defects in vitamin D metabolism or activation involves the | heritable types of rickets associated with defects in vitamin D metabolism or activation | Human | — | Not specified | Rickets.cited 129× |