The Effect of Three-Month Vitamin D Supplementation on the Levels of Homocysteine Metabolism Markers and Inflammatory Cytokines in Sera of Psoriatic Patients.
Study Goal
The researchers aimed to investigate the effects of high-dose vitamin D supplementation on homocysteine metabolism and cytokine levels in psoriatic patients with vitamin D deficiency.
Results Summary
Vitamin D supplementation (5000 IU/day) significantly improved clinical features of psoriasis (measured by PASI score) and positively affected homocysteine metabolism and cytokine levels in patients.
Population
40 psoriatic patients with vitamin D deficiency.
Effective Dosage
5000 IU/day
Duration
3 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
high doses of vitamin D supplementation | neutral | parameters of Hcy metabolism and cytokines in sera | psoriatic patients | - | investigate the effects | #1 |
vitamin D 5000 IU/day | neutral | - | 40 psoriatic patients who had the vitamin D deficiency | three months | received | #2 |
vitamin D supplementation | decrease | severity of clinical features, measured by the psoriasis area severity index (PASI) score | patients | - | considerably improved | #3 |
Psoriasis is an autoimmune and inflammatory skin disease. Psoriatic patients express higher levels of plasma homocysteine (Hcy) concentration and pro-inflammatory mediators than healthy people; this is frequently associated with vitamin D deficiency. The aim of this clinical study was to investigate the effects of high doses of vitamin D supplementation on the parameters of Hcy metabolism and cytokines in sera of psoriatic patients. This prospective study was conducted on 40 psoriatic patients who had the vitamin D deficiency. All patients received vitamin D 5000 IU/day for three months. Clinical and biochemical measurements were taken at baseline and at follow up (3 months). The results showed that the severity of clinical features, measured by the psoriasis area severity index (PASI) score, were considerably improved in patients after vitamin D supplementation. After vitamin D supplementation, most of the patients (