A Trial on The Effects of Magnesium-Zinc-Calcium-Vitamin D Co-Supplementation on Glycemic Control and Markers of Cardio-Metabolic Risk in Women with Polycystic Ovary Syndrome.
Study Goal
The researchers aimed to assess the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and cardio-metabolic risk markers in women with PCOS.
Results Summary
The co-supplementation significantly improved insulin metabolism (reduced serum insulin and insulin resistance, increased insulin sensitivity) and reduced cardio-metabolic risk markers (lower triglycerides, VLDL-cholesterol, total cholesterol, and total-/HDL-cholesterol ratio).
Population
Women with polycystic ovary syndrome (PCOS)
Effective Dosage
100 mg magnesium, 4 mg zinc, 400 mg calcium, and 200 IU vitamin D twice daily
Duration
12 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | serum insulin levels | women with polycystic ovary syndrome (PCOS) | -1.9 ± 4.6 vs. +0.4 ± 2.8 µIU/mL | significant reductions | #1 |
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | homeostatic model of assessment for insulin resistance | women with polycystic ovary syndrome (PCOS) | -0.4 ± 1.0 vs. +0.1 ± 0.6 | significant reductions | #2 |
magnesium-zinc-calcium-vitamin D co-supplementation | increase | quantitative insulin sensitivity check index | women with polycystic ovary syndrome (PCOS) | +0.01 ± 0.02 vs. -0.0003 ± 0.01 | significant increase | #3 |
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | serum triglycerides | women with polycystic ovary syndrome (PCOS) | -26.5 ± 42.9 vs. +8.9 ± 17.9 mg/dL | significantly decreased | #4 |
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | VLDL-cholesterol concentrations | women with polycystic ovary syndrome (PCOS) | -5.3 ± 8.6 vs. +1.8 ± 3.6 mg/dL | significantly decreased | #5 |
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | total cholesterol | women with polycystic ovary syndrome (PCOS) | -4.2 ± 30.7 vs. +11.1 ± 28.4 mg/dL | significantly decreased | #6 |
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | total-/HDL-cholesterol ratio | women with polycystic ovary syndrome (PCOS) | -0.04 ± 0.6 vs. +0.3 ± 0.9 | significantly decreased | #7 |
magnesium-zinc-calcium-vitamin D co-supplementation | neutral | insulin metabolism | patients with PCOS | - | had beneficial effects | #8 |
magnesium-zinc-calcium-vitamin D co-supplementation | neutral | markers of cardio-metabolic risk | patients with PCOS | - | had beneficial effects | #9 |
BACKGROUND: There is scarce data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk among women with polycystic ovary syndrome (PCOS). The objective of this study was to assess the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk in women with PCOS. METHODS: Sixty PCOS women were randomized into two groups and treated with 100 mg of magnesium, 4 mg of zinc, 400 mg of calcium plus 200 IU of vitamin D supplements (n = 30) or placebo (n = 30) twice a day for 12 weeks. Glycemic control and markers of cardio-metabolic risk were assessed at baseline and at the end of trial. RESULTS: After the 12-week intervention, compared with the placebo, magnesium-zinc-calcium-vitamin D co-supplementation supplementation resulted in significant reductions in serum insulin levels (-1.9 ± 4.6 vs. +0.4 ± 2.8 µIU/mL, P = 0.01), and homeostatic model of assessment for insulin resistance (-0.4 ± 1.0 vs. +0.1 ± 0.6, P = 0.02), as well as a significant increase in quantitative insulin sensitivity check index (+0.01 ± 0.02 vs. -0.0003 ± 0.01, P = 0.02). In addition, magnesium-zinc-calcium-vitamin D co-supplementation significantly decreased serum triglycerides (-26.5 ± 42.9 vs. +8.9 ± 17.9 mg/dL, P < 0.001), VLDL-cholesterol concentrations (-5.3 ± 8.6 vs. +1.8 ± 3.6 mg/dL, P < 0.001), total cholesterol (-4.2 ± 30.7 vs. +11.1 ± 28.4 mg/dL, P = 0.04) and total-/HDL-cholesterol ratio (-0.04 ± 0.6 vs. +0.3 ± 0.9, P = 0.04) compared with the placebo. CONCLUSION: Overall, the results of this study demonstrated that magnesium-zinc-calcium-vitamin D co-supplementation for 12 weeks among patients with PCOS had beneficial effects on insulin metabolism and markers of cardio-metabolic risk.