Vitamin D and Ovarian Cancer: Systematic Review of the Literature with a Focus on Molecular Mechanisms.
Study Goal
The researchers aimed to review the effects of vitamin D on ovarian cancer cell proliferation, progression, angiogenesis, and inflammation.
Results Summary
The study found that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer, and supplementation is linked to decreased cancer mortality. Molecular mechanisms suggest vitamin D influences cancer cell behavior.
Population
Ovarian cancer patients or models (specific population not detailed in abstract).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D | neutral | calcium metabolism | - | - | involved primarily in | #1 |
lower circulating vitamin D levels | increase | a higher risk of ovarian cancer | - | - | associated with | #2 |
vitamin D supplementation | decrease | decreased cancer mortality | - | - | associated with | #3 |
vitamin D | neutral | cancer cell proliferation | - | - | affects | #4 |
vitamin D | neutral | cancer progression | - | - | affects | #5 |
vitamin D | neutral | angiogenesis | - | - | affects | #6 |
vitamin D | neutral | inflammation | - | - | affects | #7 |
Vitamin D is a lipid soluble vitamin involved primarily in calcium metabolism. Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell.