Vitamin D and gestational diabetes: an update.
Study Goal
The researchers aimed to examine the relationship between vitamin D status (linked to sunlight exposure) and gestational diabetes mellitus (GDM), and whether supplementation could reduce GDM risk or improve glucose tolerance.
Results Summary
Observational studies on maternal vitamin D status and GDM risk were conflicting, and few interventional studies showed that supplementation optimizes maternal vitamin D status or improves glucose metabolism. High-quality RCTs are needed to clarify these effects.
Population
Pregnant women, particularly those with poor diets, dark skin, and living in temperate climates with limited sunlight exposure.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D supplementation | increase | maternal vitamin D status | pregnant women | - | optimizes | #1 |
Vitamin D supplementation | increase | maternal glucose metabolism | pregnant women | - | improves | #2 |
Vitamin D supplementation | decrease | risk of GDM | - | - | decreases | #3 |
Vitamin D supplementation | increase | glucose tolerance | diabetic women | - | improves | #4 |
PURPOSE OF REVIEW: Vitamin D status (which is involved in glucose homeostasis) is related to gestational diabetes mellitus (GDM). GDM is characterized by increased resistance to and impaired secretion of insulin and results in higher risk of adverse pregnancy outcomes including operative delivery, macrosomia, shoulder dystocia and neonatal hypoglycemia. Women with GDM and their babies are at increased risk for developing type II diabetes. RECENT FINDINGS: International definitions of vitamin D deficiency and normality are inconsistent. Vitamin D deficiency is common in pregnant women particularly those with poor diets and who have dark skins living in temperate climes with lack of exposure to sunlight. SUMMARY: Few interventional studies indicate that supplementation optimizes maternal vitamin D status or improves maternal glucose metabolism. Observational studies about maternal vitamin D status and risk of GDM are conflicting. This could be because of measurement of vitamin D or differences in population characteristics such as ethnicity, geographic location, gestational age at sampling and diagnostic criteria for GDM. Good-quality randomized controlled trials are required to determine whether vitamin D supplementation decreases the risk of GDM or improves glucose tolerance in diabetic women.