Vitamin D in gestational diabetes: A broadened frontier.
Study Goal
The researchers aimed to review the relationship between vitamin D deficiency and gestational diabetes mellitus (GDM), its pathophysiological mechanisms, and the role of vitamin D intervention in preventing and treating GDM.
Results Summary
The study found mixed results regarding the impact of vitamin D deficiency on GDM development, glycemic control, and maternal-fetal outcomes. It recommended vitamin D supplementation for pregnant women with deficiency, especially those with GDM, but noted unresolved questions about mechanisms and optimal dosage.
Population
Women of reproductive age, particularly pregnant women and those with GDM.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | decrease | gestational diabetes mellitus (GDM) | pregnant women with vitamin D deficiency | - | efficacy in reducing the risk of developing | #1 |
vitamin D deficiency | increase | gestational diabetes mellitus (GDM) | women of reproductive age during pregnancy | - | affects the development and progression of | #2 |
vitamin D deficiency | neutral | glycemic control | patients with hyperglycemia | - | affects | #3 |
vitamin D deficiency | neutral | maternal-fetal outcomes | women during pregnancy | - | affects | #4 |
vitamin D deficiency | neutral | glucose metabolism | women during pregnancy | - | underlying mechanisms of effect on | #5 |
vitamin D supplementation | neutral | prevention and treatment of GDM | all pregnant women with vitamin D deficiency, especially those with GDM | - | recommended for | #6 |
Vitamin D deficiency is very common among women of reproductive age, even during pregnancy. Different studies have yielded vastly different results regarding whether vitamin D deficiency during pregnancy affects the development and progression of gestational diabetes mellitus (GDM), glycemic control in patients with hyperglycemia, and maternal-fetal outcomes. In addition, concerns, such as the mechanisms underlying the effect of vitamin D deficiency on glucose metabolism during pregnancy, efficacy of vitamin D supplementation in reducing the risk of developing GDM, and recommended supplemental dose of vitamin D, are yet to be elucidated. This article reviewed the latest domestic and international studies in this field, with a focus on the relationship between vitamin D deficiency and GDM, their underlying pathophysiological mechanisms, and the role of vitamin D intervention in the prevention and treatment of GDM. We recommend vitamin D supplementation as soon as possible for all pregnant women with vitamin D deficiency, especially those with GDM.