Vitamin D and Visceral Obesity in Humans: What Should Clinicians Know?
Study Goal
The researchers aimed to investigate the effects of vitamin D on adipose tissue biology, including anti-inflammatory effects, adipocyte differentiation, and energy metabolism, in the context of human obesity and bariatric surgery.
Results Summary
The study found that vitamin D has consistent anti-inflammatory effects on adipose tissue, but its impact on adipocyte differentiation, adipogenesis, and energy metabolism remains inconclusive. Vitamin D supplementation showed minimal or no improvement in vitamin D status post-bariatric surgery, and benefits for visceral adipose tissue reduction were only seen in a few studies.
Population
Human obesity and bariatric surgery patients.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D | decrease | inflammation | human adipose tissue | - | anti-inflammatory effects are evident and consistent | #1 |
vitamin D | no change | adipocyte differentiation | human adipose tissue | - | effects are inconclusive | #2 |
vitamin D | no change | adipogenesis | human adipose tissue | - | effects are inconclusive | #3 |
vitamin D | no change | energy metabolism | human adipose tissue | - | effects are inconclusive | #4 |
vitamin D supplementation | no change | adipokine levels | human adipose tissue | - | effects are inconclusive | #5 |
medical and surgical weight loss | no change | vitamin D status | humans | - | have shown small or no improvement | #6 |
vitamin D supplementation | decrease | visceral adipose tissue | - | - | benefit has only been demonstrated in a few studies | #7 |
vitamin D | no change | visceral adipose tissue | humans | - | relationship is still inconclusive | #8 |
The extraskeletal effect of vitamin D on adipose tissue biology and modulation in human obesity is of great interest and has been extensively investigated. Current evidence from preclinical and clinical studies in human adipose tissue suggests that the anti-inflammatory effects of vitamin D are evident and consistent, whereas the effects of vitamin D on adipocyte differentiation, adipogenesis, and energy metabolism and the effects of vitamin D supplementation on adipokine levels are inconclusive. Interventional studies related to medical and surgical weight loss in humans have shown small or no improvement in vitamin D status. Additionally, the benefit of vitamin D supplementation for the reduction in visceral adipose tissue has only been demonstrated in a few studies. Overall, the findings on the relationship between vitamin D and visceral adipose tissue in humans are still inconclusive. Further studies are required to confirm the beneficial effects of vitamin D on ameliorating adipose tissue dysfunction.