Effects of Vitamin D Supplementation on Bone Turnover and Bone Mineral Density in Healthy Men: A Post-Hoc Analysis of a Randomized Controlled Trial.
Study Goal
The researchers aimed to examine the effects of vitamin D on bone turnover markers (CTX and osteocalcin) and bone mineral density in healthy men with low vitamin D levels.
Results Summary
The study analyzed the impact of vitamin D supplementation on bone health markers, but specific results regarding calcium's effects were not detailed in the provided abstract.
Population
200 healthy men with serum 25-hydroxyvitamin D levels <75 nmol/L.
Effective Dosage
20,000 IU of vitamin D3 per week.
Duration
Conducted between December 2012 and November 2017 (exact intervention duration not specified).
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D | neutral | calcium and mineral metabolism | - | - | well known for its effects | #1 |
vitamin D | no change | bone turnover markers (BTMs) | - | - | effects are less clear | #2 |
vitamin D | neutral | BTMs (beta-cross laps (CTX) and osteocalcin (OC)) and BMD | healthy men with serum 25-hydroxyvitamin D (25(OH)D) levels <75 nmol/L | - | examined effects | #3 |
20,000 IU of vitamin D3/week | neutral | - | Subjects | - | received | #4 |
Vitamin D is well known for its effects on calcium and mineral metabolism. However, vitamin D effects on bone turnover markers (BTMs), which are used together with bone mineral density (BMD) to evaluate bone health, are less clear. We therefore examined vitamin D effects on BTMs (beta-cross laps (CTX) and osteocalcin (OC)) and BMD in a post-hoc analysis of a randomized controlled trial (RCT). This is a post-hoc analysis of the Graz Vitamin D&TT-RCT, a single-center, double-blind, randomized placebo-controlled trial conducted between December 2012 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. A total of 200 healthy men with serum 25-hydroxyvitamin D (25(OH)D) levels <75 nmol/L participated in the trial. Subjects were randomized to receive 20,000 IU of vitamin D3/week (