Vitamin D deficiency: concern for rheumatoid arthritis and COVID-19?
Study Goal
The researchers aimed to review the association of Vitamin D (and its role in calcium metabolism) with immune-related diseases, specifically Rheumatoid Arthritis and COVID-19, and evaluate supplementation benefits.
Results Summary
The abstract notes mixed evidence regarding Vitamin D's association with Rheumatoid Arthritis and COVID-19, with some studies linking lower levels to these diseases but also reporting contrasting data. The review critically evaluates the literature on risk factors and supplementation benefits.
Population
General population with focus on immune-related diseases (Rheumatoid Arthritis and COVID-19).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D | neutral | calcium and phosphate metabolism and skeletal mineralization | - | - | is an immunomodulatory hormone with an established role | #1 |
Vitamin D | neutral | the innate and adaptive immune system | - | - | showing its immunological benefits by regulating essential components | #2 |
Vitamin D deficiency | neutral | various immune-related diseases | - | - | is found to be associated | #3 |
lower Vitamin D levels | neutral | Rheumatoid Arthritis and COVID-19 | - | - | found an association to be associated | #4 |
Vitamin D | neutral | Rheumatoid Arthritis and COVID-19 | - | - | review the available scientific data on risk factor association and supplementation benefits | #5 |
Vitamin D is an immunomodulatory hormone with an established role in calcium and phosphate metabolism and skeletal mineralization. Evidence showing its immunological benefits by regulating essential components of the innate and adaptive immune system is prevalent. Vitamin D deficiency is reported worldwide and is thereby found to be associated with various immune-related diseases. Rheumatoid Arthritis and COVID-19 are two such diseases, sharing a similar hyperinflammatory response. Various studies have found an association of lower Vitamin D levels to be associated with both these diseases. However, contrasting data is also reported. We review here the available scientific data on risk factor association and supplementation benefits of Vitamin D in Rheumatoid Arthritis and COVID-19, intending to critically evaluate the literature.