Vitamin D supplementation and bone turnover in advanced heart failure: the EVITA trial.
Study Goal
The researchers aimed to investigate the effect of a daily vitamin D supplement on bone metabolism in male heart failure patients.
Results Summary
The study found that a daily vitamin D dose of 4000 IU for 3 years increased vitamin D levels but had no significant effect on bone metabolism parameters, even in patients with very low vitamin D status.
Population
158 male heart failure patients (80 in the vitamin D group, 78 in the placebo group).
Effective Dosage
4000 IU daily
Duration
3 years
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
daily vitamin D dose of 4000 IU (moderately high dose) for 3 years | no change | parameters of bone metabolism | patients with heart failure | no significant change | had no effect | #1 |
daily vitamin D dose of 4000 IU (moderately high dose) for 3 years | no change | parameters of bone metabolism | patients with very low vitamin D status | no significant change | had no effect | #2 |
vitamin D | increase | 25OHD | 158 male HF patients | 54.3 nmol/L | increased | #3 |
vitamin D | no change | calciotropic hormones (25OHD, 1,25-dihydroxyvitamin D [1,25(OH)2D], parathyroid hormone, fibroblast growth factor-23) | 158 male HF patients | no significant change | had no effect | #4 |
vitamin D | no change | bone turnover markers (procollagen type 1 N-terminal propeptide, osteocalcin, C-terminal telopeptide of type 1 collagen) | 158 male HF patients | no significant change | had no effect | #5 |
UNLABELLED: Low vitamin D status is common in patients with heart failure and may influence bone health. A daily vitamin D dose of 4000 IU (moderately high dose) for 3 years had however no effect on parameters of bone metabolism, even in patients with very low vitamin D status. INTRODUCTION: Low vitamin D status is common in patients with heart failure (HF) and has been related to disturbed bone turnover. The present study investigated the effect of a daily vitamin D METHODS: In this pre-specified secondary analysis of a randomized controlled trial, we assessed in 158 male HF patients (vitamin D group: n = 80; placebo group: n = 78) between-group differences in calciotropic hormones (25OHD, 1,25-dihydroxyvitamin D [1,25(OH) RESULTS: Compared with placebo, vitamin D increased 25OHD on average by 54.3 nmol/L. At study termination, 25OHD and 1,25(OH) CONCLUSIONS: A daily vitamin D