The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health.
BioMed research international
January 1, 2018
R A G Khammissa et al. (6 authors)
Journal ArticleReviewHuman Study
Study Details
Study Goal
The researchers aimed to explore the role of vitamin D in calcium homeostasis and its broader physiological impacts, including immune function and keratinocyte regulation.
Results Summary
The abstract highlights vitamin D's critical role in calcium regulation, bone metabolism, immune modulation, and keratinocyte differentiation, but does not provide specific outcomes related to calcium supplementation.
Population
Not specified in the abstract.
Effective Dosage
Not mentioned.
Duration
Not mentioned.
Interactions
None mentioned.
Extracted Claims (6)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D | neutral | calcium homeostasis | - | - | plays an important role | #1 |
Vitamin D | neutral | bone metabolism | - | - | plays an important role | #2 |
Vitamin D | neutral | innate and adaptive immune function | - | - | has the capacity to modulate | #3 |
Vitamin D | neutral | cardiovascular function | - | - | has the capacity to modulate | #4 |
Vitamin D | neutral | proliferation and differentiation of normal keratinocytes | - | - | has the capacity to modulate | #5 |
Vitamin D | neutral | proliferation and differentiation of malignant keratinocytes | - | - | has the capacity to modulate | #6 |
Abstract
Vitamin D plays an important role in calcium homeostasis and bone metabolism, with the capacity to modulate innate and adaptive immune function, cardiovascular function, and proliferation and differentiation of both normal and malignant keratinocytes. 1,25(OH)
Medical Subject Headings (MeSH)
Bone and BonesCalciumCardiovascular Physiological PhenomenaCardiovascular SystemHomeostasisHumansImmune SystemNeoplasmsOral HealthReceptors, CalcitriolRetinoid X ReceptorsVitamin D
Study Links
PubMed ID29951549
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality60/10
Citation Metrics
Total Citations124
Citations/Year17.7
Relative Citation Ratio6.96
NIH Percentile96%
Research Impact Scores
APT Score0.95
Weight Score2.05
Normalized Score0.62
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