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Evidence suggests Vitamin D maydecreaseFalls.
61 studies (92 claims)
Emerging evidence
Typical effective dose 1000 (1000–1500) IUacross 3 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| high-dose vitamin D (≥ 700 IU) | Decreases - can prevent | falls | Human | adults older than 50 years | 700 IU to 2000 IU of vitamin D per day (calcium dosage not specified). | Association Between Vitamin D Supplementation and Fall Prevention.cited 15× |
| vitamin D | Decreases - prevented | falls | Human | adults older than 50 years | 700 IU to 2000 IU of vitamin D per day (calcium dosage not specified). | Association Between Vitamin D Supplementation and Fall Prevention.cited 15× |
| low-dose vitamin D (<700 IU) | No effect - was not significantly associated with | falls | Human | adults older than 50 years | 700 IU to 2000 IU of vitamin D per day (calcium dosage not specified). | Association Between Vitamin D Supplementation and Fall Prevention.cited 15× |
| the active form of vitamin D | Decreases - prevented | falls | Human | adults older than 50 years | 700 IU to 2000 IU of vitamin D per day (calcium dosage not specified). | Association Between Vitamin D Supplementation and Fall Prevention.cited 15× |
| Vitamin D supplementation | Decreases - yielded conflicting results with regard to decreasing rates | bone loss, falls and fractures | Human | — | 12,000 IU, 24,000 IU, or 48,000 IU of vitamin D3 orally each month. | Vitamin D supplementation in older people (VDOP): Study protocol for a randomised controlled intervention trial with monthly oral dosing with 12,000 IU, 24,000 IU or 48,000 IU of vitamin D₃.cited 11× |
| vitamin D supplementation | No effect - positive and negative effects | bone mineral density, musculoskeletal pain, incidence of falls | Human | — | Not specified. | Crucial Role of Vitamin D in the Musculoskeletal System.cited 142× |
| vitamin D supplementation | Decreases - reduces the risk | falls | Human | adults | Not specified | Vitamin D insufficiency.cited 498× |
| Vitamin D supplementation | Decreases - can prevent | falls | Human | the vitamin D deficient elderly | Not specified | Vitamin D and the musculoskeletal health of older adults.cited 14× |
| vitamin D supplementation | Decreases - reductions | falls | Animal | older adults with low vitamin D status | Not specified | Vitamin D and its role in skeletal muscle.cited 194× |
| vitamin D supplementation | No effect - does not reduce falls by 15% or more | falls | Human | — | Not specified | Vitamin D supplementation and falls: a trial sequential meta-analysis.cited 117× |
| vitamin D supplements | No effect - does not alter the relative risk by 15% or more | falls | Human | participants in 20 existing randomised controlled trials | Not specified | Vitamin D supplementation and falls: a trial sequential meta-analysis.cited 117× |
| vitamin D with calcium | No effect - does not reduce falls by 15% or more | falls | Human | — | Not specified | Vitamin D supplementation and falls: a trial sequential meta-analysis.cited 117× |
| vitamin D supplementation | Decreases - may benefit from | falls | Human | frail, elderly subjects | — | Vitamin D and muscle function in the elderly: the elixir of youth?cited 15× |
| vitamin D supplementation | No effect - does not decrease | falls | Human | generally healthy populations | Not specified | Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies.cited 23× |
| vitamin D supplementation | No effect - no compelling evidence for benefit was found | falls | Human | — | Not specified | Vitamin D, respiratory infections, and chronic disease: Review of meta-analyses and randomized clinical trials.cited 29× |
| Vitamin D supplementation | No effect - does not prevent | falls | Human | vitamin D-replete adults | Not specified | The health effects of vitamin D supplementation: evidence from human studies.cited 274× |
| vitamin D supplementation | Decreases - showed a significant risk reduction | falls | Human | patients with vitamin D deficiency | 800 to 1,000 IU daily | Effect of Vitamin D Supplementation on Risk of Fractures and Falls According to Dosage and Interval: A Meta-Analysis.cited 28× |
| daily administration of vitamin D | Decreases - associated with the reduced risk | falls | Human | — | 800 to 1,000 IU daily | Effect of Vitamin D Supplementation on Risk of Fractures and Falls According to Dosage and Interval: A Meta-Analysis.cited 28× |
| intermittent dose of vitamin D | No effect - was not | falls | Human | — | 800 to 1,000 IU daily | Effect of Vitamin D Supplementation on Risk of Fractures and Falls According to Dosage and Interval: A Meta-Analysis.cited 28× |
| vitamin D supplementation | Increases - has been linked to | falls and fractures | Human | older people | 800-1000 IU daily | A review of vitamin D insufficiency and its management: a lack of evidence and consensus persists.cited 5× |
| Vitamin D supplementation | Decreases - most cost-effective | falls prevention | Human | residential aged-care facilities | Not available | An economic evaluation of community and residential aged care falls prevention strategies in NSW.cited 48× |
| vitamin D supplementation | No effect - inconsistent strengths of the recommendations | falls prevention and management | Human | adults 60 years or older | Not specified | Evaluation of Clinical Practice Guidelines on Fall Prevention and Management for Older Adults: A Systematic Review.cited 169× |
| vitamin D supplementation | Decreases - may reduce | falls risk | Human | — | Not specified | The role of calcium supplementation in healthy musculoskeletal ageing : An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF).cited 116× |
| vitamin D supplementation | Decreases - does decrease | number of falls | Human | older adults at risk | Not specified | Electrolytes: Calcium Disorders.cited 3× |
| vitamin D supplementation | Decreases - support an effect of | prevention of falls | Human | older or institutionalized patients | Not specified | Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity.cited 82× |
| vitamin D supplementation | Decreases - likely benefit | rate of falls | Human | — | ≥800 IU vitamin D (with calcium, though exact calcium dosage not specified). | Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs.cited 27× |
| vitamin D supplementation | Decreases - a reduced risk of falls has been attributed to | risk of falls | HumanMolecular | — | Not specified | Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty.cited 163× |
| Vitamin D supplementation | Decreases - needed | risk of falls and fractures | Human | Frail patients | Not specified for Mediterranean Diet; protein intake recommended at 1-1.2 g per kg of body weight per day. | The role of nutrition in ageing: A narrative review from the perspective of the European joint action on frailty - ADVANTAGE JA.cited 31× |
| vitamin D therapy with adjunctive calcium | Decreases - found significant intergroup differences favoring | falls | Human | older adults | 200-1,000 IU of vitamin D, with adjunctive calcium supplementation noted in some subgroups. | Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis.cited 153× |
| vitamin D therapy with dose of 800 IU or greater | Decreases - had significantly fewer falls | falls | Human | older adults | 200-1,000 IU of vitamin D, with adjunctive calcium supplementation noted in some subgroups. | Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis.cited 153× |
| vitamin D treatment | Decreases - effectively reduces the risk | falls | Human | older adults | 200-1,000 IU of vitamin D, with adjunctive calcium supplementation noted in some subgroups. | Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis.cited 153× |
| vitamin D therapy | Decreases - had significantly fewer falls | falls | Human | older adults with no history of fractures or falls | 200-1,000 IU of vitamin D, with adjunctive calcium supplementation noted in some subgroups. | Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis.cited 153× |
| vitamin D therapy | Decreases - yielded smaller benefit | falls | Human | older adults | 200-1,000 IU of vitamin D, with adjunctive calcium supplementation noted in some subgroups. | Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis.cited 153× |
| vitamin D therapy (200-1,000 IU) | Decreases - resulted in fewer falls | falls | Human | older adults (aged > or = 60) | 200-1,000 IU of vitamin D, with adjunctive calcium supplementation noted in some subgroups. | Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis.cited 153× |
| vitamin D therapy | Decreases - had significantly fewer falls | falls | Human | community-dwelling (aged <80) | 200-1,000 IU of vitamin D, with adjunctive calcium supplementation noted in some subgroups. | Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis.cited 153× |
| vitamin D therapy with duration longer than 6 months | Decreases - had significantly fewer falls | falls | Human | older adults | 200-1,000 IU of vitamin D, with adjunctive calcium supplementation noted in some subgroups. | Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis.cited 153× |
| vitamin D therapy with adjunctive calcium supplementation | Decreases - had significantly fewer falls | falls | Human | older adults | 200-1,000 IU of vitamin D, with adjunctive calcium supplementation noted in some subgroups. | Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis.cited 153× |
| high-dose intermittent vitamin D | Increases - increase | falls | Human | — | High-dose intermittent vs. lower-dose daily (specific amounts not detailed). | A Systematic Review Supporting the Endocrine Society Clinical Practice Guidelines on Vitamin D.cited 19× |
| vitamin D supplements | No effect - fails to establish their efficacy | prevention of falls | Human | — | ≤800 IU/day | Skeletal and nonskeletal effects of vitamin D: is vitamin D a tonic for bone and other tissues?cited 32× |
| various doses and routes of administration of vitamin D | No effect - did not show efficacy | preventing falls | Human | — | Not specified | Vitamin D: 100 years of discoveries, yet controversy continues.cited 54× |
| high doses of vitamin D supplementation | Increases - increased | falls | Human | older people (aged >65 years) | Not specified | Vitamin D: 100 years of discoveries, yet controversy continues.cited 54× |
| intermittent or single high-dose vitamin D supplementation | No effect - showed no significant beneficial effect | prevention of falls | Human | — | High-dose (specific amounts not detailed in the abstract). | Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis.cited 7× |
| intermittent or single high-dose vitamin D supplementation | Increases - might even increase | risk of falls | Human | adults | High-dose (specific amounts not detailed in the abstract). | Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis.cited 7× |
| intermittent or single high-dose vitamin D supplementation | No effect - had no preventive effect | risk of falls and fractures | Human | adults | High-dose (specific amounts not detailed in the abstract). | Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis.cited 7× |
| vitamin D | Decreases - recommend | falls | Human | — | Not specified | Which vitamin D oral supplement is best for postmenopausal women?cited 7× |
| vitamin D | Decreases - may be beneficial | falls | Human | community-dwelling populations | Not specified | Effectiveness of fall prevention interventions in residential aged care and community settings: an umbrella review.cited 8× |
| vitamin D | No effect - not beneficial | falls | Human | RAC settings | Not specified | Effectiveness of fall prevention interventions in residential aged care and community settings: an umbrella review.cited 8× |
| vitamin D | Decreases - may reduce | falls | Human | people with lower vitamin D levels before treatment | Not specified | Interventions for preventing falls in older people living in the community.cited 1,989× |
| vitamin D | No effect - did not reduce | rate of falls | Human | community-dwelling older people | Not specified | Interventions for preventing falls in older people living in the community.cited 1,989× |
| vitamin D | Decreases - may reduce | falls | Human | those with the lowest serum 25-hydroxyvitamin D (25OHD) levels | Not specified | MANAGEMENT OF ENDOCRINE DISEASE: Therapeutics of Vitamin D.cited 51× |
| vitamin D | Decreases - reduced risk of | falls | Human | — | Not specified | Vitamin D and hip protectors in osteosarcopenia: a combined hip fracture preventing approach. |
| vitamin D | No effect - role remains unclear | prevention of falls and frailty | Human | — | Not specified | Prevalence of vitamin D insufficiency and evidence for disease prevention in the older population.cited 8× |
| Protein, calcium, and vitamin D supplementation | Decreases - is associated with a reduction in | falls | Human | malnourished patients | Not specified | Management of osteoporosis in patients hospitalized for hip fractures.cited 29× |
| Vitamin D and calcium supplementation (CaD) | Decreases - may reduce the risk | falls | Human | institutionalized individuals and/or those from the community | Not specified | Impact of vitamin D supplementation on falls and fractures-A critical appraisal of the quality of the evidence and an overview of the available guidelines.cited 20× |
| Vitamin D and calcium supplementation | Decreases - can reduce | risk of falls | Human | older adults in non-institutional settings | Not specified | Interventions to reduce the number of falls among older adults with/without cognitive impairment: an exploratory meta-analysis.cited 46× |
| combined vitamin D plus calcium supplementation | Decreases - has a significant effect on the reduction | risk of falls | Human | elderly individuals | Not specified in the abstract. | The effect of vitamin D and calcium supplementation on falls in older adults : A systematic review and meta-analysis.cited 28× |
| oral vitamin D regimens | No effect - failed to detect any efficacy | prevention of fracture and falls | Human | vitamin D-replete and healthy individuals | 200-2000 IU/day (recommended), 2000-100,000 IU/month (tested). | Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group.cited 47× |
| plain vitamin D (cholecalciferol) with sufficient calcium intake | Decreases - able to reduce | risk of falls and fractures | Human | — | Not specified | The effect of Vitamin D on falls and fractures.cited 29× |
| 800-1000IU/d of vitamin D | Decreases - has a benefit on prevention | falls | Human | population received daily dose regimens | 800-1000 IU/d | Effect of vitamin D, calcium, or combined supplementation on fall prevention: a systematic review and updated network meta-analysis.cited 8× |
| 800-1000IU/d of vitamin D | Decreases - has a benefit on prevention | falls | Human | population with vitamin D deficiency | 800-1000 IU/d | Effect of vitamin D, calcium, or combined supplementation on fall prevention: a systematic review and updated network meta-analysis.cited 8× |
| vitamin D supplementation at 800-1000 IU/d | Decreases - is associated with a lower risk | falls | Human | older adults | 800-1000 IU/d | Effect of vitamin D, calcium, or combined supplementation on fall prevention: a systematic review and updated network meta-analysis.cited 8× |
| adequate vitamin D intake | Decreases - is associated with decreased risk | falls | Human | the elderly | Not specified | Vitamin D in health and disease.cited 36× |
| calcium plus vitamin D combination | Decreases - was more effective than calcium alone or placebo in reducing | falls | HumanAnimalMolecular | some elderly subgroups | Not specified | Vitamin D "insufficiency" in adults. Beware of vague concepts with uncertain clinical relevance. |
| daily high dose of vitamin D | No effect - had no benefit | incidence of total falls | Human | generally healthy, active, and vitamin D-replete older adults | 2000 international units/day of vitamin D3 | Effects of vitamin D, omega-3 fatty acids, and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial.cited 21× |
| daily supplemental vitamin D | No effect - had no benefit | injurious falls | Human | generally healthy and active older adults | 2000 international units/day of vitamin D3 | Effects of vitamin D, omega-3 fatty acids, and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial.cited 21× |
| daily supplemental vitamin D | No effect - had no benefit | total falls | Human | generally healthy and active older adults | 2000 international units/day of vitamin D3 | Effects of vitamin D, omega-3 fatty acids, and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial.cited 21× |
| vitamin D formulations (with or without calcium) | No effect - showed no significant difference | falls | Human | community-dwelling adults 65 years and older | One trial used annual high-dose cholecalciferol (500,000 IU); others unspecified. | Interventions to Prevent Falls in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.cited 254× |
| vitamin D-calcium supplement | No effect - some studies failed to show any effect | falls and fractures | Human | — | Not specified | Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects.cited 84× |
| vitamin D-calcium supplement | Decreases - others reported a significant decrease | falls and fractures | Human | — | Not specified | Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects.cited 84× |
| exercise including progressive resistance training and nutritional strategies, including protein and vitamin D supplementation | Decreases - thereby reducing | falls and fracture risk | Human | this population | Not specified | Fall and Fracture Risk in Sarcopenia and Dynapenia With and Without Obesity: the Role of Lifestyle Interventions.cited 70× |
| calcium and vitamin D supplementation | Decreases - effective in the prevention of | falls | Human | elderly population | 1000 mg of calcium and 800 IU of vitamin D daily. | Prevention of falls and fractures in old people by administration of calcium and vitamin D, randomized clinical trial.cited 7× |
| calcium and vitamin D supplementation | Decreases - determine the effectiveness in decreasing | number of falls | Human | person aged over 65 years | 1000 mg of calcium and 800 IU of vitamin D daily. | Prevention of falls and fractures in old people by administration of calcium and vitamin D, randomized clinical trial.cited 7× |
| Calcium and vitamin D supplementation | Decreases - widely recommended for prevention | falls and fracture | Human | the elderly | Not specified | The vitamin D and calcium controversy: an update.cited 9× |
| holistic vitamin D supplementation with or without calcium | No effect - unlikely to be an effective primary prevention strategy | falls or fracture | Human | — | Not specified | The vitamin D and calcium controversy: an update.cited 9× |
| calcium and vitamin D supplementation | Decreases - decreased | incidence of multiple falls requiring medical attention | Human | entire trial population | 1000mg calcium carbonate + 800IU cholecalciferol daily. | Does daily vitamin D 800 IU and calcium 1000 mg supplementation decrease the risk of falling in ambulatory women aged 65-71 years? A 3-year randomized population-based trial (OSTPRE-FPS).cited 40× |
| calcium and vitamin D supplementation | No effect - showed no association | risk of falls | Human | null | 1000mg calcium carbonate + 800IU cholecalciferol daily. | Does daily vitamin D 800 IU and calcium 1000 mg supplementation decrease the risk of falling in ambulatory women aged 65-71 years? A 3-year randomized population-based trial (OSTPRE-FPS).cited 40× |
| calcium and vitamin D supplementation | No effect - was not associated with | single or multiple falls | Human | entire trial population | 1000mg calcium carbonate + 800IU cholecalciferol daily. | Does daily vitamin D 800 IU and calcium 1000 mg supplementation decrease the risk of falling in ambulatory women aged 65-71 years? A 3-year randomized population-based trial (OSTPRE-FPS).cited 40× |
| vitamin D and calcium | Decreases - reducing the risk | falls and fractures | Human | — | Not specified | Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk.cited 21× |
| subclinical vitamin D deficiency | Increases - is associated with | higher incidence of falls or fractures | Human | — | 400 international units of vitamin D daily for breastfed infants. | Vitamin D and health - The missing vitamin in humans.cited 192× |
| Daily vitamin D in addition to calcium supplementation | Decreases - reduces | falls and fractures | Human | older women | Participants were advised to increase dietary calcium intake, but no specific calcium dosage was provided. | Effects of three-monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility, and muscle strength in older postmenopausal women: a randomized controlled trial.cited 106× |
| an intermittent, high-dose vitamin D regimen | No effect - cannot be supported as a strategy to reduce | falls and fractures | Human | — | Participants were advised to increase dietary calcium intake, but no specific calcium dosage was provided. | Effects of three-monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility, and muscle strength in older postmenopausal women: a randomized controlled trial.cited 106× |
| intermittent large doses of vitamin D | No effect - are ineffective or have a deleterious effect | falls | Human | — | Participants were advised to increase dietary calcium intake, but no specific calcium dosage was provided. | Effects of three-monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility, and muscle strength in older postmenopausal women: a randomized controlled trial.cited 106× |
| large annual bolus administration of vitamin D | Increases - is detrimental | falls and fractures | Human | older adults at risk of fractures | 800-1000 IU daily or equivalent weekly/monthly doses; large annual bolus doses were harmful. | Should vitamin D administration for fracture prevention be continued? : A discussion of recent meta-analysis findings.cited 5× |
| daily vitamin D supplement of at least 400 IU or preferably 800 IU of vitamin D₃ | Decreases - can reduce the risk | falls | Human | elderly subjects | 400-800 IU/d of vitamin D₃ | Why modest but widespread improvement of the vitamin D status is the best strategy?cited 11× |
| high vitamin D doses | Increases - appear to be harmful | falls | Human | people without vitamin D deficiency and at low fracture risk | 1000-1200 mg/day calcium co-supplemented with at least 800 IU/day vitamin D. | Vitamin D supplementation and fracture risk: Evidence for a U-shaped effect.cited 20× |
| 500 000 IU of vitamin D annually for 5 y | No effect - did not contribute to reducing | fracture risk and falls | Human | women in postmenopause without osteoporosis | 400 IU, 800-1000 IU, 4000 IU, 15,000 IU/week, 500,000 IU annually (vitamin D); 1200 mg (calcium). | Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal women without osteoporosis: A systematic review of randomized clinical trials.cited 6× |
| vitamin D deficiency | Increases - has also been reported to increase the risk of | falls and osteoporotic fractures | Human | — | Not specified | New developments in our understanding of vitamin metabolism, action and treatment.cited 69× |
| supplemental vitamin D | No effect - does not indicate that should be used | primary prevention of falls | Human | the US population | 1 g/day | VITamin D and OmegA-3 TriaL (VITAL): Effects of Vitamin D Supplements on Risk of Falls in the US Population.cited 63× |
| mega doses and even moderate doses (as low as 4000IU a day) of vitamin D | Increases - may increase | falls | Human | older populations | 1000 mg calcium once daily. | A randomized, controlled pilot study of the effects of vitamin D supplementation on balance in Parkinson's disease: Does age matter?cited 49× |
| vitamin D supplementation alone | No effect - did not show a reduced risk | falls | Human | participants | Calcium: 1000-1200 mg daily; Vitamin D: 700-1000 IU daily. | Vitamin D supplementation reduces the risk of fall in the vitamin D deficient elderly: An updated meta-analysis.cited 24× |
| vitamin D supplementation alone | Decreases - does have a benefit | prevention of falls | Human | old adults with 25(OH)D levels lower than 50 nmol/L | Calcium: 1000-1200 mg daily; Vitamin D: 700-1000 IU daily. | Vitamin D supplementation reduces the risk of fall in the vitamin D deficient elderly: An updated meta-analysis.cited 24× |