Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis.
Study Goal
The researchers aimed to determine whether intermittent or single high-dose vitamin D supplementation affects the risk of falls and fractures in adults.
Results Summary
The meta-analysis found no significant preventive effect of high-dose vitamin D on falls or fractures and suggested a potential increase in fall risk. The pooled relative risk for falls was 1.03 (95% CI, 0.98-1.09).
Population
Adults (specific age or health status not detailed in the abstract).
Effective Dosage
High-dose (specific amounts not detailed in the abstract).
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
intermittent or single high-dose vitamin D supplementation | no change | risk of falls and fractures | adults | - | had no preventive effect | #1 |
intermittent or single high-dose vitamin D supplementation | increase | risk of falls | adults | - | might even increase | #2 |
intermittent or single high-dose vitamin D supplementation | no change | prevention of falls | - | RR, 1.03 [95% CI, 0.98-1.09] | showed no significant beneficial effect | #3 |
UNLABELLED: Previous randomized controlled trials have reported inconsistent findings regarding the effects of high-dose vitamin D supplementation on a risk of falls and fractures. This meta-analysis of 15 trials shows that intermittent or single high-dose vitamin D supplementation had no preventive effect on the risk of falls and fractures and might even increase the risk of falls. PURPOSE: Randomized controlled trials (RCTs) have reported controversial findings regarding the associations between intermittent or single high-dose vitamin D supplementation and a risk of falls and fractures in adults. This study aimed to investigate those associations using a systematic review and meta-analysis. METHODS: We searched PubMed, EMBASE, and Cochrane Library from inception to May 25, 2022. Data were extracted for a random-effects meta-analysis to calculate a pooled relative risk (RR) with a 95% confidence interval (CI). RESULTS: Out of 527 articles, a total of 15 RCTs were included in the final analysis. In a meta-analysis of RCTs, intermittent or single high-dose vitamin D supplementation showed no significant beneficial effect in the prevention of either falls (RR, 1.03 [95% CI, 0.98-1.09]; I CONCLUSIONS: Intermittent or single high-dose vitamin D supplementation had no preventive effect on the risk of falls and fractures and might even increase the risk of falls.