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The effect of vitamin D and calcium supplementation on falls in older adults : A systematic review and meta-analysis.

Der Orthopade
September 1, 2017
Haiting Wu et al. (2 authors)
Journal ArticleMeta-AnalysisReviewSystematic ReviewHuman Study
Study Details

Study Goal

The researchers aimed to assess the effect of vitamin D, particularly when combined with calcium, on reducing the risk of falls in elderly individuals.

Results Summary

The meta-analysis found that combined calcium plus vitamin D supplementation significantly reduced the risk of falls (OR 0.87; 95% CI, 0.80-0.94), while vitamin D2 or D3 alone showed no significant effect.

Population

Elderly individuals (16,540 in the intervention group, 16,146 in control groups).

Effective Dosage

Not specified in the abstract.

Duration

Not specified in the abstract.

Interactions

None mentioned.

Extracted Claims (4)
InterventionDirectionEndpointPopulationDosageImpactClaim #
combined vitamin D plus calcium supplementation
decrease
risk of falls
elderly individuals
OR, 0.87; 95% CI, 0.80-0.94
has a significant effect on the reduction
#1
vitamin D2
no change
reduction in the risk of falls
elderly individuals
OR, 0.77; 95% CI, 0.58-1.03
no significant association
#2
vitamin D3
no change
reduction in the risk of falls
elderly individuals
OR, 1.08; 95% CI, 0.98-1.20
no significant association
#3
combined calcium plus vitamin D supplementation
decrease
fall risks
various populations
-
statistically significantly associated with a reduction
#4
Abstract

OBJECTIVES: A number of studies have hypothesized that vitamin D is a potential factor in the prevention of falls in the elderly; however, the effect of vitamin D is still inconsistent and not quantitative. We conducted this meta-analysis to assess the effect of vitamin D on falls among elderly individuals. METHODS: The PubMed and Cochrane Library databases were searched from the earliest possible year up to December 2016. Two authors working independently reviewed the trials, and odds ratios (ORs) were calculated using a fixed-effect or random-effect model by Review Manager 5.3. We included only double-blind randomized, controlled trials (RCTs) of vitamin D in elderly populations that examined fall results. RESULTS: A total of 26 articles were included in which 16,540 elderly individuals received vitamin D supplementation, while 16,146 were assigned to control groups. The meta-analysis showed that combined vitamin D plus calcium supplementation has a significant effect on the reduction in the risk of falls (OR for the risk of suffering at least one fall, 0.87; 95% CI, 0.80-0.94). However, no significant association between vitamin D2 or D3 and a reduction in the risk of falls was found (OR, 0.77; 95% CI, 0.58-1.03 for vitamin D2, and OR, 1.08; 95% CI, 0.98-1.20 for vitamin D3). CONCLUSIONS: Combined calcium plus vitamin D supplementation is statistically significantly associated with a reduction in fall risks across various populations.

Medical Subject Headings (MeSH)
Accidental FallsAgedAged, 80 and overCalcium CarbonateDietary SupplementsDrug Therapy, CombinationFemaleFrail ElderlyHumansMaleRandomized Controlled Trials as TopicVitamin D
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality90/10
Citation Metrics
Total Citations28
Citations/Year3.5
Relative Citation Ratio1.37
NIH Percentile61.8%
Research Impact Scores
APT Score0.75
Weight Score2.20
Normalized Score0.72
Related Supplements
The effect of vitamin D and calcium supplementation on falls... | Panacea Index