Effect of vitamin D, calcium, or combined supplementation on fall prevention: a systematic review and updated network meta-analysis.
Study Goal
The researchers aimed to assess the efficacy of vitamin D, calcium, and combined supplementation in preventing falls among older adults.
Results Summary
Vitamin D supplementation at 800-1000 IU/d was associated with a lower risk of falls in older adults, particularly in those receiving daily doses and those with vitamin D deficiency. The study included 35 RCTs with low heterogeneity, supporting the conclusion.
Population
Older adults
Effective Dosage
800-1000 IU/d
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation at 800-1000 IU/d | decrease | falls | older adults | - | is associated with a lower risk | #1 |
800-1000IU/d of vitamin D | decrease | falls | population received daily dose regimens | - | has a benefit on prevention | #2 |
800-1000IU/d of vitamin D | decrease | falls | population with vitamin D deficiency | - | has a benefit on prevention | #3 |
BACKGROUND: The association between vitamin D supplementation and the risk of falls in older adults has been controversial. This systematic review and network meta-analysis aims to assess the efficacy of vitamin D, calcium, and combined supplementation in the prevention of falls. METHODS: Randomized controlled trials (RCTs) on the efficacy of vitamin D in fall prevention were systematically searched in PubMed, Embase, Cochrane Library, and Web of Science from inception to May 9, 2023. The network meta-analysis was performed using a random effects model in R4.1.3 and Stata15.0. Heterogeneity was evaluated by the I RESULTS: A total of 35 RCTs involving 58,937 participants were included in this study, among which 11 RCTs (31.4%) applied calcium combined with vitamin D. There was low heterogeneity (I CONCLUSION: Vitamin D supplementation at 800-1000 IU/d is associated with a lower risk of falls among older adults. 800-1000IU/d of vitamin D has a benefit on prevention of falls in population received daily dose regimens and in population with vitamin D deficiency.