10
13
8
↑10
↓13
—8
Evidence suggests Vitamin D maydecreaseOsteoporosis.
41 studies (31 claims)
Conflicting evidence
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| calcium and vitamin D | No effect - have been the primary focus | nutritional prevention of osteoporosis | Human | — | Not specified | Update on nutrients involved in maintaining healthy bone.cited 22× |
| calcium and Vitamin D | Decreases - can prevent the development | osteoporosis | Human | patients during ADT | Not available | The use of dietary supplements to alleviate androgen deprivation therapy side effects during prostate cancer treatment.cited 17× |
| calcium and vitamin D | Decreases - considered crucial in the prevention and treatment | osteoporosis | Human | — | Not specified | Calcium supplementation in osteoporosis: useful or harmful?cited 43× |
| vitamin D supplementation | Decreases - is a key pillar of osteoporosis prevention | osteoporosis | Human | postmenopausal women | Not specified | Which vitamin D oral supplement is best for postmenopausal women?cited 7× |
| vitamin D supplementation | Decreases - are important | osteoporosis | Human | CKD patients | Not specified | Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.cited 88× |
| vitamin D supplementation | Decreases - treatment and prevention | osteoporosis | Human | — | Not specified | Vitamin D, the natural way.cited 19× |
| controlled sun exposure and proper vitamin D diet | Decreases - preventive strategy | osteoporosis and other diseases associated with low vitamin D | Human | general population | Not specified | Vitamin D, the natural way.cited 19× |
| vitamin D supplementation | No effect - should be considered | prevention of osteomalacia and as a basis for the treatment of osteoporosis | Human | patients with distal radius fractures | Not specified | Pre-existing osteoporosis and serum vitamin D levels in patients with distal radius fractures: are we missing something?cited 1× |
| vitamin D | No effect - not demonstrated convincing evidence that could improve | bone mineral density (BMD), osteoporosis and fracture | Human | — | Not specified | Circulating serum vitamin D levels and total body bone mineral density: A Mendelian randomization study.cited 17× |
| vitamin D in combination with calcium supplementation | No effect - not demonstrated convincing evidence that could improve | bone mineral density (BMD), osteoporosis and fracture | Human | — | Not specified | Circulating serum vitamin D levels and total body bone mineral density: A Mendelian randomization study.cited 17× |
| vitamin D | No effect - main use was in treating | osteoporosis and rickets | Human | — | Not mentioned | Immune Modulation by Vitamin D: Special Emphasis on Its Role in Prevention and Treatment of Cancer.cited 38× |
| vitamin D | No effect - used by | osteoporosis prevention | Human | patients with recent falls | Not specified | Pharmacological management of osteoporosis in nursing home residents: the Shelter study.cited 6× |
| vitamin D | No effect - used by | osteoporosis prevention | Human | residents with severe cognitive impairment | Not specified | Pharmacological management of osteoporosis in nursing home residents: the Shelter study.cited 6× |
| vitamin D | No effect - used by | osteoporosis prevention | Human | bisphosphonate users | Not specified | Pharmacological management of osteoporosis in nursing home residents: the Shelter study.cited 6× |
| vitamin D | No effect - used by | osteoporosis prevention | Human | nursing home residents | Not specified | Pharmacological management of osteoporosis in nursing home residents: the Shelter study.cited 6× |
| vitamin D | No effect - Often prescribed for treating | rickets and osteoporosis | Human | — | Not specified. | Revisiting the significance of nano-vitamin D for food fortification and therapeutic application. |
| adequate intake of calcium and supplementation of vitamin D | No effect - baseline therapeutic approach | osteoporosis treatment | Human | — | Not mentioned | Monoclonal antibodies for treatment of osteoporosis.cited 3× |
| Low levels of vitamin D | Increases - is associated with | osteoporosis | Human | SLE patients | Not specified | Vitamin D and systemic lupus erythematosus: an update.cited 62× |
| adequate intakes of calcium and vitamin D | No effect - are essential preventive strategies and essential parts | osteoporosis | Human | — | 800 to 1000 mg/d total calcium intake (including supplements if dietary intake is insufficient). | Calcium supplementation, osteoporosis and cardiovascular disease.cited 21× |
| inadequate intake of calcium and vitamin D | Increases - has been associated with a rising incidence of | osteoporosis | Human | regions such as Asia and Africa | Not specified | Strategies for preventing bone loss in populations with insufficient calcium and vitamin D intake. |
| vitamin D and calcium supplementation | No effect - should be added to | every specific medical treatment of osteoporosis | Human | — | Not specified | The effect of Vitamin D on falls and fractures.cited 29× |
| vitamin D metabolites 25(OH)D and 1,25(OH)(2)D | No effect - important for | all types and clinical stages of osteoporosis | Human | — | Not specified | The effect of Vitamin D on falls and fractures.cited 29× |
| Vitamin D and calcium supplementation | No effect - is recommended for | osteoporosis | Human | all patients with osteoporosis | Not specified | Osteoporosis in chronic liver disease.cited 23× |
| Vitamin D and calcium supplementation | Decreases - should be recommended | osteoporosis | Human | all patients with chronic liver diseases and osteoporosis | Not specified | Hepatic Osteodystrophy: A Global (Re)View of the Problem.cited 16× |
| Combined calcium and vitamin D supplementation | Decreases - could prevent | osteoporosis hip fracture | Human | postmenopausal women | Vitamin D dose ≤400 IU/day (specific calcium dosage not mentioned). | Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.cited 89× |
| supplements of calcium and vitamin D | No effect - are given with | drug treatments for osteoporosis | Human | — | 300 to 2,000 mg/day (mentioned as adaptable range, not study-specific dosage). | Calcium and Bone.cited 7× |
| supplement of nutritional vitamin D | Decreases - is important in treating | uremic osteoporosis and vascular calcification | Human | — | Not specified | Mineral bone disorders in chronic kidney disease.cited 62× |
| supplementation with calcium and vitamin D | No effect - recommended | glucocorticoid-induced osteoporosis | Human | adults under long-term glucocorticoid therapy | Not specified | German Society of Rheumatology recommendations for management of glucocorticoid-induced osteoporosis.cited 9× |
| vitamin D use | No effect - additional focus should be on sufficient | osteoporosis treatment | Human | rheumatoid arthritis patients | — | Management of osteoporosis in rheumatoid arthritis patients.cited 59× |
| calcium and vitamin D supplementation | Decreases - used for the treatment | osteoporosis | Human | — | Not specified. | Pharmacological agents and natural compounds: available treatments for osteoporosis.cited 76× |
| calcium and vitamin D supplementation | No effect - is a key component of prevention and treatment of | osteoporosis | Human | patients unless calcium intake and vitamin D status are optimal | 800 IU/day vitamin D (calcium dosage not specified) | Reducing fracture risk with calcium and vitamin D.cited 122× |
| calcium and vitamin D supplementation | No effect - are non-pharmacologic treatment options | osteoporosis | Human | — | Not specified | Fragility Fractures: Diagnosis and Treatment.cited 14× |
| calcium and vitamin D supplementation | Decreases - can be prevented by the use of | osteoporosis and fractures | Human | patients at high risk of osteoporosis and fractures | Not specified | Cancer Treatment and Bone Health.cited 43× |
| calcium and vitamin D supplementation | No effect - is less effective | prevention of glucocorticoid-induced osteoporosis | Human | patients receiving or initiating glucocorticoid therapy | — | Glucocorticoid-induced osteoporosis: who to treat with what agent?cited 124× |
| calcium and vitamin D supplementation | No effect - generally advised | secondary osteoporosis | Human | — | — | Current and future treatments of secondary osteoporosis.cited 16× |
| subclinical vitamin D deficiency | Increases - is associated with | osteoporosis | Human | — | 400 international units of vitamin D daily for breastfed infants. | Vitamin D and health - The missing vitamin in humans.cited 192× |
| Vitamin D deficiency | Increases - linked to the development | diabetes mellitus, hypertension, cancer, and osteoporosis | Human | — | Not available. | Phosphocalcic metabolism and the role of vitamin D, vitamin K2, and nattokinase supplementation.cited 15× |
| vitamin D deficiency | No effect - relevant nongenetic factor | etiology of osteoporosis and hypertension | Human | — | Not specified | The relationship among hypertension, antihypertensive medications, and osteoporosis: a narrative review.cited 75× |
| Vitamin D deficiency | No effect - causes | osteopenia and osteoporosis | Human | — | 2000 IU/d for adults, 1000 IU/d for children. | Vitamin D: a d-lightful solution for health.cited 138× |
| vitamin D deficiency | Increases - may lead to | osteoporosis (osteomalacia in adults and rickets in children) | Human | adults and children | Not specified | Prevalence of hypovitaminosis D in India & way forward.cited 41× |
| Vitamin D deficiency | Increases - can cause or exacerbate | osteoporosis | Human | adults | Not specified | Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review.cited 45× |
| Vitamin D deficiency | Increases - increases the risk of | osteoporosis | Human | — | Not specified | Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review.cited 45× |
| Vitamin D deficiency | Increases - is closely associated with | osteoporosis prevalence | Human | — | Not specified | Vitamin D deficiency and chronic obstructive pulmonary disease: a vicious circle.cited 47× |
| vitamin D deficiency | Increases - can lead to | skeletal complications of osteopenia and osteoporosis | Human | individuals with cystic fibrosis (CF) | Higher doses of vitamin D (specific amounts not provided) | Vitamin D deficiency and its treatment in cystic fibrosis.cited 38× |
| vitamin D intake | Increases - had significantly greater knowledge | osteoporosis knowledge | Human | patients with prostate cancer receiving androgen-deprivation therapy | Not specified | Osteoporosis knowledge, health beliefs, and healthy bone behaviours in patients on androgen-deprivation therapy (ADT) for prostate cancer.cited 31× |