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Vitamin D: a d-lightful solution for health.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research
August 1, 2011
Michael F Holick
Journal ArticleResearch Support, N.I.H., ExtramuralReviewHuman Study
Study Details

Study Goal

The researchers aimed to highlight the critical role of vitamin D in calcium absorption and skeletal health, as well as its broader implications for various diseases.

Results Summary

The study found that vitamin D is essential for efficient intestinal calcium absorption, maintaining skeletal health, and preventing deficiencies linked to multiple diseases, including osteoporosis, diabetes, and cancer. It recommends sensible sun exposure and vitamin D supplementation (2000 IU/d for adults, 1000 IU/d for children) for optimal health.

Population

General population, with specific mention of children and adults.

Effective Dosage

2000 IU/d for adults, 1000 IU/d for children.

Duration

Not specified.

Interactions

None mentioned.

Extracted Claims (16)
InterventionDirectionEndpointPopulationDosageImpactClaim #
sunlight-produced vitamin D
neutral
health
-
-
has been critically important for
#1
vitamin D
increase
intestinal calcium and phosphate absorption
-
-
interacts with its receptor in the small intestine to increase the efficiency of
#2
vitamin D
neutral
the skeleton
-
-
maintenance of
#3
Vitamin D deficiency during the first few years of life
neutral
a flattened pelvis
-
-
results in
#4
Vitamin D deficiency
neutral
osteopenia and osteoporosis
-
-
causes
#5
Vitamin D deficiency
increase
fracture
-
-
increasing risk of
#6
vitamin D deficiency
increase
preeclampsia
-
-
has been linked to increased risk for
#7
vitamin D deficiency
increase
multiple sclerosis
-
-
has been linked to increased risk for
#8
vitamin D deficiency
increase
rheumatoid arthritis
-
-
has been linked to increased risk for
#9
vitamin D deficiency
increase
types I and II diabetes
-
-
has been linked to increased risk for
#10
vitamin D deficiency
increase
heart disease
-
-
has been linked to increased risk for
#11
vitamin D deficiency
increase
dementia
-
-
has been linked to increased risk for
#12
vitamin D deficiency
increase
deadly cancers
-
-
has been linked to increased risk for
#13
vitamin D deficiency
increase
infectious diseases
-
-
has been linked to increased risk for
#14
sensible sun exposure along with vitamin D supplementation of at least 2000 IU/d
neutral
health
adults
2000 IU/d
is essential to maximize
#15
sensible sun exposure along with vitamin D supplementation of at least 1000 IU/d
neutral
health
children
1000 IU/d
is essential to maximize
#16
Abstract

Throughout evolution, sunlight-produced vitamin D in the skin has been critically important for health. Vitamin D, known as the sunshine vitamin, is actually a hormone. Once it is produced in the skin or ingested from the diet, it is converted sequentially in the liver and kidneys to its biologically active form 1,25-dihydroxyvitamin D. This hormone interacts with its receptor in the small intestine to increase the efficiency of intestinal calcium and phosphate absorption for the maintenance of the skeleton throughout life. Vitamin D deficiency during the first few years of life results in a flattened pelvis, making it difficult for childbirth. Vitamin D deficiency causes osteopenia and osteoporosis, increasing risk of fracture. Essentially, every tissue and cell in the body has a vitamin D receptor. Therefore, vitamin D deficiency has been linked to increased risk for preeclampsia, requiring a cesarean section for birthing, multiple sclerosis, rheumatoid arthritis, types I and II diabetes, heart disease, dementia, deadly cancers, and infectious diseases. Therefore, sensible sun exposure along with vitamin D supplementation of at least 2000 IU/d for adults and 1000 IU/d for children is essential to maximize their health.

Medical Subject Headings (MeSH)
AdolescentAdultAgedCalciumChildChild, PreschoolDietDietary SupplementsFemaleHealthHumansInfantInfant, NewbornMaleMiddle AgedModels, BiologicalReceptors, CalcitriolSkinSunlightVitamin DVitamin D DeficiencyVitamins
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality75/10
Citation Metrics
Total Citations138
Citations/Year9.9
Relative Citation Ratio5.04
NIH Percentile93.1%
Research Impact Scores
APT Score0.95
Weight Score1.47
Normalized Score0.69
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