Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review.
Study Goal
The researchers aimed to investigate the link between Vitamin D deficiency, osteoporosis, and associated chronic diseases.
Results Summary
The study found that Vitamin D deficiency is correlated with osteoporosis and various chronic diseases, including autoimmune, inflammatory, and metabolic disorders. Adequate Vitamin D supplementation may help manage these conditions.
Population
Adults (general population, with focus on those at risk for osteoporosis and chronic diseases).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D deficiency | increase | osteoporosis | adults | - | can cause or exacerbate | #1 |
Vitamin D deficiency | increase | osteomalacia | adults | - | can induce | #2 |
Vitamin D deficiency | decrease | organs (brain, heart, stomach, pancreas, skin, gonads, immune cells) | - | - | may modify the function of | #3 |
reduction in VD amount | increase | numerous chronic diseases | - | - | has been correlated with | #4 |
Vitamin D deficiency | increase | osteoporosis | - | - | increases the risk of | #5 |
Vitamin D deficiency | increase | several other diseases and complications characterized by impaired bone metabolisms | - | - | increases the risk of | #6 |
adequate vitamin supplementation and restoration of metabolic normality | decrease | these pathologies | - | - | could be useful for better management of | #7 |
Vitamin D (VD) is essential for bone homeostasis, but it is also involved in pleiotropic effects on various organs and tissues. In adults, VD deficiency can cause or exacerbate osteoporosis and induce osteomalacia. However, every tissue and cell in the body has a VD receptor, including the brain, heart, stomach, pancreas, skin, gonads, and immune cells, and a deficiency may modify the function of these organs. Thus, the wide-ranging actions of VD help to explain why a reduction in VD amount has been correlated with numerous chronic diseases. In fact, VD deficiency increases the risk of osteoporosis and several other diseases and complications characterized by impaired bone metabolisms, such as autoimmune diseases, inflammatory bowel diseases, allergy, endocrinological diseases, hematological malignancies, and bone marrow transplantation. This review aims to investigate the link between VD deficiency, osteoporosis, and its concomitant diseases. Further epidemiological and mechanistic studies are necessary in order to ascertain the real role of hypovitaminosis in causing the reported diseases; however, adequate vitamin supplementation and restoration of metabolic normality could be useful for better management of these pathologies.