Phosphocalcic metabolism and the role of vitamin D, vitamin K2, and nattokinase supplementation.
Study Goal
The researchers aimed to explore the roles of vitamins D and K in calcium and phosphorus metabolism and their broader physiological impacts.
Results Summary
The study highlights the importance of vitamins D and K in calcium and phosphorus metabolism, linking vitamin D deficiency to conditions like diabetes, hypertension, cancer, and osteoporosis, and associating vitamin K with reduced risks of osteoporosis, cancer, and cardiovascular diseases.
Population
Not specified (general review, no specific population studied).
Effective Dosage
Not available.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D | neutral | bone formation, carbohydrate metabolism, immune responses, and cardiovascular regulation | - | - | plays a regulatory role | #1 |
Vitamin D deficiency | increase | diabetes mellitus, hypertension, cancer, and osteoporosis | - | - | linked to the development | #2 |
Vitamin K | decrease | osteoporosis, cancer, and cardiovascular diseases | - | - | associated with a reduced risk | #3 |
Vitamin K | increase | vascular elasticity | - | - | improved | #4 |
nattokinase | decrease | thrombotic events | - | - | role in thrombotic prevention | #5 |
nattokinase | increase | fibrinolysis | - | - | due to its fibrinolytic activity | #6 |
Calcium is involved in bone metabolism, regulation of nerve signaling, and release of neurotransmitters. Phosphorus is a structural component of ATP, participates in metabolic energy regulation, and ensures stability to biological membranes and cells. Vitamin D and vitamin K are important for intestinal absorption and renal excretion of calcium and phosphorus. Vitamin D plays a regulatory role in bone formation, carbohydrate metabolism, immune responses, and cardiovascular regulation. Research has linked vitamin D deficiency to the development of diabetes mellitus, hypertension, cancer, and osteoporosis. Vitamin K has been associated with a reduced risk of osteoporosis, cancer, and cardiovascular diseases (due to improved vascular elasticity). This review highlights the importance of vitamins D and K in the metabolism of calcium and phosphorus and explores various molecular mechanisms that help maintain the system's mineral homeostasis. Moreover, the paper reviews the enzyme nattokinase's role in thrombotic prevention due to its fibrinolytic activity.