26
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3
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Evidence suggests Melatonin mayincreaseRetinal sensitivity.
29 studies (38 claims)
Moderate consensus
Typical effective dose 10 (9–10) mgacross 8 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin administration | Increases - significantly increased | insulin sensitivity | Human | patients with diabetic nephropathy (DN) | 10 mg/d | Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy.cited 17× |
| melatonin administration | Increases - increasing | insulin sensitivity | Human | — | 5 mg melatonin tablets twice daily. | Effects of melatonin supplementation on metabolic parameters, oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: study protocol for a double-blind, randomized controlled trial.cited 1× |
| melatonin administration | Increases - significantly increased | quantitative insulin sensitivity check index (QUICKI) | Human | women with polycystic ovary syndrome (PCOS) | 10 mg melatonin (two 5 mg capsules) once daily before bedtime. | Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.cited 58× |
| melatonin administration | Increases - significantly increased | quantitative insulin sensitivity check index | Human | diabetic hemodialysis (HD) patients | 2 x 5mg/day (10mg total daily dose), taken 1 hour before bedtime. | The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.cited 39× |
| melatonin administration | Decreases - significant reduction | serum high sensitivity C-reactive protein | Human | diabetic hemodialysis (HD) patients | 2 x 5mg/day (10mg total daily dose), taken 1 hour before bedtime. | The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.cited 39× |
| melatonin administration | Decreases - resulted in significant decreases | serum high sensitivity C-reactive protein (hs-CRP) levels | Human | diabetic patients with CHD | 10 mg melatonin (2 capsules of 5 mg each) once daily. | Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial.cited 94× |
| melatonin treatment | Increases - significantly increased | quantitative insulin sensitivity check index | Human | diabetic patients with CHD | 10 mg melatonin (2 capsules of 5 mg each) once daily. | Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial.cited 94× |
| high doses of melatonin | Decreases - significantly reduced | insulin sensitivity index | Human | whole group | Four doses of 10 mg oral melatonin. | Acute metabolic effects of melatonin-A randomized crossover study in healthy young men.cited 17× |
| high doses of melatonin | Decreases - significantly reduced | insulin sensitivity index | Human | homozygous carriers of the rs10830963 C-allele | Four doses of 10 mg oral melatonin. | Acute metabolic effects of melatonin-A randomized crossover study in healthy young men.cited 17× |
| acute administration of melatonin in supra-physiological doses | Decreases - may have a negative impact | insulin sensitivity | Human | — | Four doses of 10 mg oral melatonin. | Acute metabolic effects of melatonin-A randomized crossover study in healthy young men.cited 17× |
| melatonin | Increases - induction | cancer cells sensitivity to the chemotherapy agents | Human | — | Not specified. | The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor.cited 28× |
| melatonin | No effect - had no significant impact | high-sensitivity C-reactive protein (hs-CRP) | Human | children diagnosed with atopic dermatitis (AD) | 6 mg/d melatonin | The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double-blinded, placebo-controlled trial.cited 34× |
| melatonin | No effect - regulatory effects on | hormone production and insulin sensitivity | Human | PCOS individuals | Not specified | Melatonin: Current evidence on protective and therapeutic roles in gynecological diseases.cited 4× |
| Melatonin | Increases - increased | insulin sensitivity | HumanMolecular | animals fed with either high fat or high sucrose diet | Not specified. | Metabolic syndrome, its pathophysiology and the role of melatonin. |
| Melatonin | Increases - increased | insulin sensitivity | HumanMolecular | animals fed with either high fat or high sucrose diet | Not specified. | Metabolic syndrome, its pathophysiology and the role of melatonin. |
| melatonin | No effect - affects | insulin sensitivity | Human | — | Not specified | Chronomedicine and type 2 diabetes: shining some light on melatonin.cited 44× |
| melatonin | Increases - ameliorated | insulin sensitivity | Human | — | Not specified in the abstract. | Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.cited 8× |
| melatonin supplementation | Increases - increased | quantitative insulin sensitivity check index (QUICKI) | Human | 376 participants | Not specified in the abstract. | Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.cited 8× |
| melatonin | Increases - may increase | insulin sensitivity | Human | — | — | The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal?cited 7× |
| melatonin | Increases - may also be associated with | insulin sensitivity | Human | ICU patients | — | Sleep in the intensive care unit.cited 7× |
| melatonin | Increases - improved | insulin sensitivity | Animal | high-fat diet-induced obese mice | — | New evidence of melatonin receptor contribution to ram sperm functionality. |
| Melatonin | Increases - improved | insulin sensitivity | Human | patients with metabolic syndrome | — | Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. |
| Melatonin | Increases - improved | insulin sensitivity | Human | Patients with rare MTNR1B variants | — | Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study. |
| Melatonin | Increases - improved | insulin sensitivity | Human | T2D MTNR1B variant carriers | — | Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study. |
| Melatonin | Increases - improved | insulin sensitivity | Human | patients with metabolic syndrome | — | Melanogenesis Is Directly Affected by Metabolites of Melatonin in Human Melanoma Cells. |
| Melatonin | Increases - increases | light sensitivity | Molecular | horizontal cells | — | Role of melatonin and its receptors in the vertebrate retina. |
| melatonin | No effect - effect was abolished | light sensitivity of rod photoreceptors | Animal | MT1(-/-) or MT2(-/-) mice | — | Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. |
| melatonin | No effect - effect was abolished | light sensitivity of rod photoreceptors | Animal | mice overexpressing a nonfunctional MT2 mutant | — | Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. |
| melatonin | Increases - mediated the effect on the light sensitivity | light sensitivity of rod photoreceptors | Animal | mice | — | Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. |
| melatonin | No effect - involved in | neuronal sensitivity | Human | — | Not specified | Ocular and systemic melatonin and the influence of light exposure.cited 76× |
| melatonin | Increases - has therapeutic mechanisms including | restoring insulin sensitivity | Human | — | Not specified | The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease.cited 38× |
| melatonin | Increases - correct these alterations in favour of sensitization to antineoplastic agents | sensitivity to antineoplastic agents | HumanMolecular | cancer cells | Not specified | Does the use of melatonin overcome drug resistance in cancer chemotherapy?cited 36× |
| melatonin | Increases - improves the sensitivity of cancers to inhibition | sensitivity to conventional drugs | Human | — | Not specified | Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.cited 310× |
| melatonin | Increases - renders cancers previously totally resistant to treatment sensitive | sensitivity to therapies | Human | — | Not specified | Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.cited 310× |
| long-term melatonin treatment (10 mg daily) | Decreases - decreased | insulin sensitivity | Human | male participants with type 2 diabetes | — | Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.cited 17× |
| long-term melatonin treatment (10 mg daily) | Decreases - decreased | insulin sensitivity | Human | male patients with type 2 diabetes | — | Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.cited 17× |
| melatonin supplementation | Increases - higher | quantitative insulin sensitivity check index | Human | patients under methadone maintenance treatment (MMT) | — | The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment.cited 35× |
| melatonin intake | Decreases - significant reduction in | serum high sensitivity C-reactive protein | Human | patients under methadone maintenance treatment (MMT) | — | The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment.cited 35× |
| melatonin supplementation | Decreases - significant reduction | serum high sensitivity C-reactive protein (hs-CRP) | Human | patients with PD | 10 mg melatonin (two 5 mg capsules) once daily before bedtime. | Melatonin supplementation and the effects on clinical and metabolic status in Parkinson's disease: A randomized, double-blind, placebo-controlled trial.cited 53× |
| oily emulsion of docosahexaenoic acid (DHA)-phospholipids containing melatonin and tryptophan | Increases - significant treatment effect | olfactory sensitivity assessment | Human | elderly subjects with mild cognitive impairment (MCI) | Not specified | Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment.cited 55× |