New evidence of melatonin receptor contribution to ram sperm functionality.
Reproduction, fertility, and development
June 1, 2016
Marta Gonzalez-Arto et al. (6 authors)
Journal ArticleAnimal Study
Extracted Claims (20)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | adipogenesis | 3T3-L1 preadipocytes | - | inhibited | #1 |
melatonin | decrease | lipid accumulation | 3T3-L1 preadipocytes | - | reduced | #2 |
melatonin | decrease | expression of adipogenic transcription factors | 3T3-L1 preadipocytes | - | downregulated | #3 |
melatonin | increase | phosphorylation of AMPK | 3T3-L1 preadipocytes | - | increased | #4 |
melatonin | increase | phosphorylation of ACC | 3T3-L1 preadipocytes | - | increased | #5 |
melatonin | increase | expression of UCP1 | 3T3-L1 preadipocytes | - | increased | #6 |
melatonin | increase | expression of PGC-1α | 3T3-L1 preadipocytes | - | increased | #7 |
melatonin | increase | mitochondrial biogenesis | 3T3-L1 preadipocytes | - | increased | #8 |
melatonin | increase | oxygen consumption rate | 3T3-L1 preadipocytes | - | increased | #9 |
melatonin | increase | energy expenditure | 3T3-L1 preadipocytes | - | increased | #10 |
melatonin | increase | browning of white adipocytes | 3T3-L1 preadipocytes | - | promoted | #11 |
melatonin | decrease | body weight gain | high-fat diet-induced obese mice | - | reduced | #12 |
melatonin | increase | glucose tolerance | high-fat diet-induced obese mice | - | improved | #13 |
melatonin | increase | insulin sensitivity | high-fat diet-induced obese mice | - | improved | #14 |
melatonin | increase | energy expenditure | high-fat diet-induced obese mice | - | increased | #15 |
melatonin | increase | thermogenesis | high-fat diet-induced obese mice | - | enhanced | #16 |
melatonin | increase | expression of UCP1 | high-fat diet-induced obese mice | - | increased | #17 |
melatonin | increase | expression of PGC-1α | high-fat diet-induced obese mice | - | increased | #18 |
melatonin | increase | mitochondrial content | high-fat diet-induced obese mice | - | increased | #19 |
melatonin | increase | browning of white adipose tissue | high-fat diet-induced obese mice | - | increased | #20 |
Abstract
The present study analysed the involvement of melatonin, acting via its receptors (MT
Medical Subject Headings (MeSH)
AnimalsMaleMelatoninReceptor, Melatonin, MT1Receptor, Melatonin, MT2SheepSperm CapacitationSpermatozoaTetrahydronaphthalenes
Study Links
PubMed ID25515626
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