The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor.
Study Goal
The researchers aimed to review melatonin's potential therapeutic effects on breast cancer by modulating cancer cell invasion and metastasis.
Results Summary
Melatonin demonstrated anti-metastatic properties, including suppression of tumor proliferation, induction of apoptosis, regulation of the cell cycle, modulation of angiogenesis, and enhancement of chemotherapy sensitivity. Recent findings also highlight its effects on cancer stem cells and vascular mimicry.
Population
Breast cancer (no specific patient subgroup mentioned).
Effective Dosage
Not specified.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | breast cancer | - | - | has the potential to prevent metastatic and invasive nature | #1 |
melatonin | decrease | cancer invasion and metastasis | - | - | protective effect | #2 |
melatonin | decrease | tumor proliferation | - | - | suppression | #3 |
melatonin | increase | tumor apoptosis | - | - | induction | #4 |
melatonin | neutral | the cell cycle | - | - | regulation | #5 |
melatonin | neutral | angiogenesis | - | - | modulating | #6 |
melatonin | decrease | invasion | - | - | impediment | #7 |
melatonin | increase | cancer cells sensitivity to the chemotherapy agents | - | - | induction | #8 |
melatonin | decrease | breast cancer | - | - | anti-metastatic effect | #9 |
Breast cancer is the most common cancer among women and its metastasis which generally observed at the last stage is the major cause of breast cancer-related death. Therefore, the agents that have the potential to prevent metastatic and invasive nature of breast cancer can open up new therapeutic strategies. Melatonin, a major hormone of pineal gland, is a powerful anti-cancer agent. There are growing evidence regarding the protective effect of melatonin against cancer invasion and metastasis. The anti-metastatic feature of melatonin accompanies with suppression of tumor proliferation, induction of tumor apoptosis, regulation of the cell cycle, modulating angiogenesis, impediment of invasion, and induction of cancer cells sensitivity to the chemotherapy agents. More recently, anti-metastatic effect of melatonin through affecting cancer stem cells and vascular mimicry has been identified. Thus, the aim of this review is to discuss the potential therapeutic effect of melatonin on breast cancer via modulating the cells invasion and metastasis.