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Evidence suggests Melatonin maydecreaseInflammation.
118 studies (125 claims)
Strong consensus
Typical effective dose 10 (5–19.5) mgacross 10 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| night-time melatonin | Decreases - attenuated capacity to dampen | residual daytime inflammation | Human | — | Not specified | A More Holistic Perspective of Alzheimer's Disease: Roles of Gut Microbiome, Adipocytes, HPA Axis, Melatonergic Pathway and Astrocyte Mitochondria in the Emergence of Autoimmunity.cited 7× |
| melatonin administration | No effect - modulating | inflammation | Human | — | 5 mg melatonin tablets twice daily. | Effects of melatonin supplementation on metabolic parameters, oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: study protocol for a double-blind, randomized controlled trial.cited 1× |
| melatonin | Decreases - alleviated | adipocyte inflammation | AnimalMolecular | — | Not specified. | Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice.cited 136× |
| melatonin | Decreases - inhibition of | adipose inflammation | AnimalMolecular | — | Not specified. | Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice.cited 136× |
| melatonin | Decreases - attenuated | adipose inflammation | AnimalMolecular | chronic jet-lag mice | Not specified. | Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice.cited 136× |
| melatonin | Decreases - alleviated | inflammation | AnimalMolecular | obese mice | Not specified. | Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice.cited 136× |
| melatonin | Decreases - alleviates | metabolic inflammation | AnimalMolecular | — | Not specified. | Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice.cited 136× |
| melatonin | Increases - plays a role in | anti-inflammation | Human | — | Not specified | Melatonin in Alzheimer's disease.cited 147× |
| melatonin | Decreases - is potentially effective | cancer, inflammation and neurodegenerative diseases | Human | — | Not specified. | Antioxidant Nanoplatforms for Dermal Delivery: Melatonin.cited 10× |
| melatonin | Decreases - able to reduce or mitigate | cell damage associated with oxidative stress and inflammation | Human | — | Not specified | The role of melatonin in multiple sclerosis, Huntington's disease and cerebral ischemia.cited 43× |
| melatonin | Decreases - could yield beneficial effects | chronic inflammation | Human | — | Not specified | Anti-inflammatory effects of Melatonin: A mechanistic review.cited 95× |
| melatonin | Decreases - attenuated | chronic inflammation | Human | animal models of CKD | Not specified | Melatonin and renal protection: novel perspectives from animal experiments and human studies (review).cited 35× |
| melatonin | No effect - immunomodulatory effect | chronic inflammation | Human | — | 3 mg/day | Impact of Melatonin on Motor, Cognitive and Neuroimaging Indices in Patients with Multiple Sclerosis.cited 22× |
| melatonin | Decreases - inhibits | chronic inflammation and metastasis | Molecular | — | — | Melatonin: A Potential Antineoplastic Agent in Breast Cancer. |
| melatonin | Decreases - inhibits | chronic inflammation and metastasis | Molecular | — | — | Melatonin: A Potential Antineoplastic Agent in Breast Cancer. |
| melatonin | Decreases - may act as a potential therapeutic agent for alleviating | chronic inflammation associated with COPD | HumanAnimal | — | — | An Integrative Transcriptomic and Metabolomic Study Revealed That Melatonin Plays a Protective Role in Chronic Lung Inflammation by Reducing Necroptosis. |
| melatonin | Decreases - alleviate | chronic lung inflammation | HumanAnimal | mouse model | — | An Integrative Transcriptomic and Metabolomic Study Revealed That Melatonin Plays a Protective Role in Chronic Lung Inflammation by Reducing Necroptosis. |
| melatonin | No effect - protective effect | chronic lung inflammation | HumanAnimal | mouse model | — | An Integrative Transcriptomic and Metabolomic Study Revealed That Melatonin Plays a Protective Role in Chronic Lung Inflammation by Reducing Necroptosis. |
| melatonin | No effect - long-term prevention | chronic inflammation that leads to gastroesophageal reflux disease (GERD) and Barrett's esophagus | Human | — | Not specified | Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett's Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives.cited 20× |
| melatonin | Decreases - exerts a significant cytoprotective action | free radicals and inflammation | Human | — | 2-10mg/day in humans (clinical trials), 100mg/day suggested for cytoprotective effects (animal studies). | Melatonin and healthy aging.cited 37× |
| melatonin | Decreases - suppression | low degree inflammation | Human | — | 2-10mg/day in humans (clinical trials), 100mg/day suggested for cytoprotective effects (animal studies). | Melatonin and healthy aging.cited 37× |
| melatonin | Decreases - alleviated | gouty inflammation | HumanAnimalMolecular | — | — | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. |
| melatonin | Decreases - reduce | inflammation index | HumanAnimalMolecular | C57BL/6 mice (gouty arthritis model) | — | Melatonin Alleviates Acute Gouty Inflammation In Vivo and In Vitro. |
| melatonin | No effect - modulation | inflammation | Human | — | Not available | A Review of Data of Findings on Night Shift Work and the Development of DM and CVD Events: a Synthesis of the Proposed Molecular Mechanisms.cited 58× |
| melatonin | Decreases - anti-inflammation | inflammation | Human | — | Not provided | The Potentials of Melatonin in the Prevention and Treatment of Bacterial Meningitis Disease.cited 9× |
| melatonin | Decreases - diminishing inflammation | inflammation | Human | — | Not specified | Melatonin, a promising supplement in inflammatory bowel disease: a comprehensive review of evidences.cited 45× |
| melatonin | Decreases - potential as an alternative to conventional drug therapies for the disorders associated with the MS | inflammation | Human | experimental animal models of diabetes, obesity and MS | Pharmacological doses between 5 and 20 mg/kg body weight in animal models; clinical studies used 0.050–0.16 mg/kg body weight. | Melatonin and metabolic regulation: a review.cited 56× |
| melatonin | Decreases - may be potential agents for counteracting | inflammation | Animal | aging heart | Not specified | Protective actions of melatonin and growth hormone on the aged cardiovascular system.cited 22× |
| melatonin | Decreases - anti-inflammatory features | inflammation | Human | — | Not specified | Clinical Uses of Melatonin in Neurological Diseases and Mental and Behavioural Disorders.cited 50× |
| melatonin (MLT) | Decreases - possesses a number of antidiabetic health benefits | inflammation | HumanMolecular | in vitro and in vivo studies | Not specified | Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer.cited 7× |
| melatonin | Decreases - protective roles against | inflammation | Human | AD at early stage | Not specified | Melatonin in Synaptic Impairments of Alzheimer's Disease. |
| melatonin | Decreases - protective roles against | inflammation | Human | AD at early stage | Not specified | Melatonin in Synaptic Impairments of Alzheimer's Disease. |
| melatonin | Decreases - helpful in controlling | inflammation | HumanMolecular | cancer-cell | Not specified | Mitochondrial functions and melatonin: a tour of the reproductive cancers.cited 39× |
| melatonin | Decreases - anti-inflammatory activities | inflammation | Human | — | Not specified | Melatonin is a potential inhibitor of ovarian cancer: molecular aspects.cited 26× |
| melatonin | Decreases - leads to inhibition | inflammation | Human | PD | Not specified | Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms.cited 47× |
| melatonin | Decreases - anti-inflammatory | inflammation | Human | — | Not specified | Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies.cited 23× |
| melatonin | Decreases - has remarkable anti-inflammatory effects | inflammation | Human | — | Not specified | Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19.cited 52× |
| melatonin | Decreases - protects against inflammation | inflammation | Human | — | Not specified | Role of melatonin in periodontal disease - A systematic review.cited 12× |
| melatonin | Decreases - reported protective effects | inflammation | Human | several organs including the heart, brain, and teeth | Not specified | Effects of melatonin in wound healing of dental pulp and periodontium: Evidence from in vitro, in vivo and clinical studies.cited 9× |
| melatonin | Decreases - has been shown to reduce | inflammation | Human | — | Not specified | Effects of melatonin in wound healing of dental pulp and periodontium: Evidence from in vitro, in vivo and clinical studies.cited 9× |
| melatonin | Decreases - has a significant beneficial effect on inflammation | inflammation | Human | — | Not specified | The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review.cited 20× |
| melatonin | No effect - orchestrates several molecular mechanisms involved in obesity and associated inflammation | obesity and associated inflammation | Human | — | Not specified | The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review.cited 20× |
| melatonin (MEL) | Decreases - anti-inflammatory agent | inflammation | Human | — | Not specified (wide range reported). | Effects of Melatonin on Diabetic Neuropathy and Retinopathy.cited 14× |
| Melatonin | Decreases - seems to reduce | inflammation | Human | patients suffering from insomnia disorder | Not specified | Sleep Immune Cross Talk and Insomnia.cited 23× |
| melatonin | Decreases - alleviates | inflammation | Human | — | Not specified | Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer.cited 3× |
| melatonin | Decreases - decreasing | inflammation | Molecular | cardiac cells | Not specified | Insight into the cardioprotective effects of melatonin: shining a spotlight on intercellular Sirt signaling communication.cited 1× |
| melatonin | Decreases - reduction of | inflammation | Molecular | — | Not specified | Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review.cited 5× |
| melatonin | No effect - impacts | inflammation | Molecular | — | Not specified | Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review.cited 5× |
| melatonin | Decreases - regulating inflammation | inflammation | Human | — | Suggested effective cytoprotective dose: 100 mg/day; current clinical trial doses: 2-10 mg. | Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant.cited 3× |
| melatonin | Decreases - suppressing low-grade inflammation | low-grade inflammation | Human | — | Suggested effective cytoprotective dose: 100 mg/day; current clinical trial doses: 2-10 mg. | Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant.cited 3× |
| melatonin treatment | Decreases - prevents | a wide range of low-inflammation-linked alterations | Human | animal models of NCDs | Suggested effective cytoprotective dose: 100 mg/day; current clinical trial doses: 2-10 mg. | Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant.cited 3× |
| melatonin | Decreases - demonstrated protective effects | inflammation | Human | — | Not specified | Unveiling the Protective Roles of Melatonin on Glial Cells in the Battle Against Alzheimer's Disease-Insights from In Vivo and In Vitro Studies. |
| Melatonin | Decreases - reduced | inflammation | Human | human participants | — | Nociceptive responses in melatonin MT |
| Melatonin | Decreases - reduced | inflammation | Human | patients with hypertension | — | Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. |
| Melatonin | Decreases - reduced | inflammation | Human | patients with metabolic syndrome | — | Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. |
| Melatonin | Decreases - reduced | inflammation | Human | patients with coronary artery disease | — | Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. |
| Melatonin | Decreases - reduced | inflammation | Human | patients with heart failure | — | Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. |
| melatonin | Decreases - may reduce | inflammation | Human | — | — | Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer's disease model. |
| melatonin (MEL) | Decreases - reduced | inflammation | Animal | rats | — | The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta. |
| melatonin | Decreases - reduces inflammation | inflammation | Human | CNS | Not specified | Peripheral and central effects of melatonin on blood pressure regulation. |
| melatonin | Decreases - reduces inflammation | inflammation | Human | CNS | Not specified | Peripheral and central effects of melatonin on blood pressure regulation. |
| melatonin (MLT) | Decreases - inhibiting | inflammation | Molecular | — | — | Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury. |
| melatonin | Decreases - reduced | inflammation | Human | human participants | — | Differential Function of Melatonin MT |
| melatonin | Decreases - downregulates the overreaction of innate immune response | inflammation | Human | — | Not specified | Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality.cited 16× |
| melatonin | Decreases - is an anti-inflammatory and anti-oxidative molecule | inflammation and oxidation | Human | — | Not specified | Clinical Trials for Use of Melatonin to Fight against COVID-19 Are Urgently Needed.cited 45× |
| melatonin | Decreases - modulating | inflammation and oxidative stress | Human | — | Not specified | Melatonin: Evolving Physiological Understanding and Potential Therapeutic Role in Pain Medicine Including Intervertebral Disc Degeneration.cited 1× |
| Melatonin | Decreases - effective anti-inflammatory agent | inflammation and sepsis | Human | various animal models | Not specified | Melatonin in septic shock: some recent concepts.cited 64× |
| melatonin | Decreases - reduces | inflammation associated with periodontitis | Human | — | Not specified | Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms.cited 2× |
| melatonin | Decreases - mitigates | inflammation in acrylamide-induced lung injury | Animal | rats | — | The effects of melatonin on oxidative stress, inflammation, apoptosis and Nrf2/HO-1 in acrylamide-induced lung injury in rats. |
| melatonin | Decreases - notably alleviated | inflammation in the PVN | AnimalMolecular | mice | — | Alleviation of inflammation in paraventricular nucleus and sympathetic outflow by melatonin efficiently repairs endplate porosities and attenuates spinal hyperalgesia. |
| melatonin via activation of MT2 | Decreases - inhibits | inflammation in endplate | AnimalMolecular | mice | — | Alleviation of inflammation in paraventricular nucleus and sympathetic outflow by melatonin efficiently repairs endplate porosities and attenuates spinal hyperalgesia. |
| melatonin via activation of MT2 | Decreases - inhibits | inflammation in PVN | AnimalMolecular | mice | — | Alleviation of inflammation in paraventricular nucleus and sympathetic outflow by melatonin efficiently repairs endplate porosities and attenuates spinal hyperalgesia. |
| melatonin | Decreases - use in the control of inflammation | inflammation underlying the above mentioned diseases | Human | patients with neurodegenerative and bowel diseases | Not specified | Role of Melatonin in the Inflammatory Process and its Therapeutic Potential.cited 73× |
| Melatonin | No effect - Cytoprotective effects | involve a myriad of prominent receptor-mediated pathways/molecules associated with inflammation | Human | — | Not specified | Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes.cited 88× |
| melatonin | Decreases - therapeutic interventions specifically aimed at reducing | levels of inflammation and oxidative stress | Human | — | Not specified | The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders.cited 39× |
| melatonin | Decreases - had an inhibitory effect | LPS-induced endometrial epithelial cell inflammation | AnimalMolecular | sheep | — | Melatonin protects sheep endometrial epithelial cells against lipopolysaccharide-induced inflammation in vitro. |
| Melatonin | No effect - has beneficial effects on | mucus production and inflammation | Human | — | Not available | Diurnal variation in asthma symptoms: Exploring the role of melatonin. |
| Melatonin | No effect - has beneficial effects on | mucus production and inflammation | Human | — | Not available | Diurnal variation in asthma symptoms: Exploring the role of melatonin. |
| melatonin | Decreases - protects | ocular tissues against inflammation | Human | — | Not specified | Melatonin as a Therapeutic Resource for Inflammatory Visual Diseases.cited 13× |
| melatonin | Decreases - protection | oxidative stress and inflammation | Human | renal disorders | Not specified | The role of melatonin treatment in chronic kidney disease.cited 38× |
| Melatonin | Decreases - has been effectively used to combat | oxidative stress, inflammation and cellular apoptosis | Human | human trials | Not specified | Melatonin as an antioxidant: under promises but over delivers.cited 1,080× |
| melatonin | No effect - shed light on the modulatory functions | pain, local inflammation and motility in the gastrointestinal tract | Human | — | — | Agomelatine, a novel therapeutic option for the management of irritable bowel syndrome. |
| melatonin | Decreases - reduces | pro-inflammation cytokines | Animal | rats and mice | — | A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies.cited 9× |
| melatonin | No effect - play a part in | regulation of inflammation | Human | — | — | Could melatonin have a potential adjuvant role in the treatment of the lasting anosmia associated with COVID-19? A review.cited 2× |
| melatonin | Decreases - reduce | SAH-associated inflammation | Human | — | Not specified | Role of Adaptor Protein Myeloid Differentiation 88 (MyD88) in Post-Subarachnoid Hemorrhage Inflammation: A Systematic Review.cited 17× |
| melatonin | Decreases - showed high potency in reduction of | the oxidative stress and inflammation markers | Human | — | Not specified | Exercise-induced oxidative stress and melatonin supplementation: current evidence.cited 49× |
| melatonin | Decreases - may reduce | uncontrolled hyper-inflammation | Human | — | Not specified | Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders.cited 22× |
| melatonin | No effect - review the evidence on the effect | vascular inflammation | Human | — | Not specified | The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis.cited 13× |
| melatonin type 2 receptor agonist IIK-7 | Decreases - suppression of | proteins involved in inflammation and apoptosis | AnimalMolecular | — | — | Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats. |
| exogenous application of melatonin in pharmacological doses | Decreases - has been associated with reduced | inflammation | Human | a variety of animal models | Pharmacological doses (specific amounts not provided) | Detection of melatonin production from the intestinal epithelium using electrochemical methods.cited 16× |
| melatonin treatment (HFD-Mi + M) | Decreases - significantly reduced | inflammation | Animal | — | Not specified | Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics. |
| melatonin (MEL) intake associated with intradialytic exercise | Decreases - displays potential immunoregulatory and anti-inflammatory effects | systemic inflammation and immune responses | Human | hemodialysis (HD) patients | 3 mg, ingested 1 hour before exercise or equivalent time in control condition. | Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients.cited 9× |
| melatonin (MEL) intake | Decreases - displays potential immunoregulatory and anti-inflammatory effects | systemic inflammation and immune responses | Human | hemodialysis (HD) patients | 3 mg, ingested 1 hour before exercise or equivalent time in control condition. | Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients.cited 9× |
| 4-week intervention of melatonin and essential aminoacid supplementation | No effect - No significant changes | inflammation | Human | 159 elderly sarcopenic patients | 4 g EAA daily. | Is a Combination of Melatonin and Amino Acids Useful to Sarcopenic Elderly Patients? A Randomized Trial.cited 6× |
| sublingual consumption of melatonin | Decreases - reducing | necrosis and inflammation | Human | patients undergoing CABG | 12 mg sublingual melatonin the evening before and 1 hour before surgery. | The Effects of Melatonin on the Oxidative Stress and Duration of Atrial Fibrillation after Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial.cited 16× |
| exogenously administered melatonin | Decreases - seems to attenuate | inflammation | Human | professional football players | 5-8 mg | The Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review.cited 6× |
| melatonin supplementation | Decreases - showed anti-inflammatory actions | inflammation | Human | — | 5-8 mg | The Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review.cited 6× |
| Knockout of both melatonin receptors type 1A (MT1) and 1B (MT2) | Increases - exacerbated | inflammation | Animal | aging mice | — | Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice. |
| Apigenin (APG) and Melatonin (MEL) in combination with nanostructured lipid carriers (NLC) | Decreases - may provide a synergistic effect | treating ocular inflammation | AnimalMolecular | — | Not specified in the abstract. | Combination of Apigenin and Melatonin with nanostructured lipid carriers as anti-inflammatory ocular treatment. |
| melatonin supplementation | Decreases - is a promising complementary strategy to attenuate | inflammation | Human | diabetic patients | Not specified in the abstract. | Effects of melatonin supplementation on markers of inflammation and oxidative stress in patients with diabetes: A systematic review and meta-analysis of randomized controlled trials.cited 11× |
| melatonin supplementation | Decreases - normalized | inflammation response | Animal | DSS-treated mice | — | Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways. |
| melatonin supplementation | Increases - was associated with enhanced | oxidative stress and inflammation status | Human | patients with MS | Not specified | Clinical efficacy and safety of melatonin supplementation in multiple sclerosis: a systematic review.cited 11× |
| melatonin supplementation | No effect - investigate the change in | systemic inflammation | Human | MS patients | 3 mg/night | 12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial. |
| pharmacological doses of melatonin | Decreases - have anti-inflammatory properties | inflammation | Molecular | various in vitro cellular models | Pharmacological doses mentioned (specific amounts not provided). | Melatonin in energy control: Circadian time-giver and homeostatic monitor.cited 7× |
| melatonin and tryptophan | Decreases - reduced | the inflammation in liver | Human | few patients with NASH | 2 x 5 mg/day | Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease--14 months follow up.cited 109× |
| melatonin receptors (MT1, MT2, MT3) | No effect - involvement in the regulation of | GI motility, inflammation and pain | Human | — | Not specified | Distribution, function and physiological role of melatonin in the lower gut. |
| melatonin receptors (MT1, MT2, MT3) | No effect - involvement in the regulation of | GI motility, inflammation and pain | Human | — | Not specified | Distribution, function and physiological role of melatonin in the lower gut. |
| melatonin therapy after the stroke | Decreases - cause to alleviate | inflammation | Human | — | Not specified | Effect of Melatonin on Endoplasmic Reticulum-Mitochondrial Crosstalk in Stroke.cited 17× |
| melatonin in combination with other drugs such as antibiotics, resveratrol, and anti-oxidants | Decreases - showing synergistic effects in reducing | inflammation | Human | — | Not specified | Melatonin as a potential treatment for septic cardiomyopathy.cited 11× |
| subcutaneous melatonin implants | Increases - exhibited varying degrees of | uterine inflammation | Animal | female cats | 18 mg melatonin implants (subcutaneous, single administration) | Effects of melatonin implants on uterine inflammation and ovarian progesterone receptor expression in female cats: A histopathological and molecular analysis. |
| subcutaneous melatonin implants | Increases - may induce | uterine inflammation | Animal | female cats | 18 mg melatonin implants (subcutaneous, single administration) | Effects of melatonin implants on uterine inflammation and ovarian progesterone receptor expression in female cats: A histopathological and molecular analysis. |
| Supplementation with propolis and melatonin | Decreases - by reducing | inflammation | Human | patients with primary pneumosepsis | — | Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients with Primary Pneumosepsis: A Randomized Controlled Clinical Trial.cited 17× |
| antioxidant hormones like melatonin | Decreases - target cellular signaling pathways to reduce intestinal inflammation | intestinal inflammation | Human | IBD | Not specified | Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease.cited 113× |
| Melatonin and Ginseng | Decreases - significantly inhibited | apoptosis, inflammation and autophagy markers | Animal | rats | 100 mg/kg (oral gavage). | Effect of Melatonin and Ginseng on rat testis and sperm quality against cadmium toxicity via inhibiting oxidative stress and autophagy pathways. |
| melatonin or analogs | Decreases - should be considered as a pharmacological approach to suppress | inflammation and circadian misalignment | Human | ASD patients | Not specified | Dysregulation of Circadian Rhythms in Autism Spectrum Disorders.cited 24× |