melatonin Decreases - diminishing inflammation inflammation Human
— Not specified Melatonin, a promising supplement in inflammatory bowel disease: a comprehensive review of evidences. cited 45× melatonin Decreases - potential as an alternative to conventional drug therapies for the disorders associated with the MS inflammation Human
experimental animal models of diabetes, obesity and MS Pharmacological doses between 5 and 20 mg/kg body weight in animal models; clinical studies used 0.050–0.16 mg/kg body weight. Melatonin and metabolic regulation: a review. cited 56× melatonin Decreases - reduces inflammation inflammation Human
CNS Not specified Peripheral and central effects of melatonin on blood pressure regulation. melatonin Decreases - may be potential agents for counteracting inflammation Animal
aging heart Not specified Protective actions of melatonin and growth hormone on the aged cardiovascular system. cited 22× melatonin Decreases - anti-inflammatory features inflammation Human
— Not specified Clinical Uses of Melatonin in Neurological Diseases and Mental and Behavioural Disorders. cited 50× melatonin (MLT) Decreases - possesses a number of antidiabetic health benefits inflammation Human Molecular
in vitro and in vivo studies Not specified Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer. cited 7× melatonin Decreases - alleviated inflammation Animal Molecular
obese mice Not specified. Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice. cited 136× melatonin Decreases - protective roles against inflammation Human
AD at early stage Not specified Melatonin in Synaptic Impairments of Alzheimer's Disease. melatonin No effect - modulation inflammation Human
— Not available A Review of Data of Findings on Night Shift Work and the Development of DM and CVD Events: a Synthesis of the Proposed Molecular Mechanisms. cited 58× melatonin Decreases - helpful in controlling inflammation Human Molecular
cancer-cell Not specified Mitochondrial functions and melatonin: a tour of the reproductive cancers. cited 39× melatonin Decreases - reduced inflammation Human
human participants — Differential Function of Melatonin MT melatonin Decreases - anti-inflammatory activities inflammation Human
— Not specified Melatonin is a potential inhibitor of ovarian cancer: molecular aspects. cited 26× melatonin Decreases - leads to inhibition inflammation Human
PD Not specified Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms. cited 47× melatonin Decreases - anti-inflammatory inflammation Human
— Not specified Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies. cited 23× Melatonin Decreases - reduced inflammation Human
human participants — Nociceptive responses in melatonin MT melatonin Decreases - has remarkable anti-inflammatory effects inflammation Human
— Not specified Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19. cited 52× Melatonin Decreases - reduced inflammation Human
patients with hypertension — Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. Melatonin Decreases - reduced inflammation Human
patients with metabolic syndrome — Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. Melatonin Decreases - reduced inflammation Human
patients with coronary artery disease — Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. Melatonin Decreases - reduced inflammation Human
patients with heart failure — Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. melatonin Decreases - protects against inflammation inflammation Human
— Not specified Role of melatonin in periodontal disease - A systematic review. cited 12× melatonin Decreases - reported protective effects inflammation Human
several organs including the heart, brain, and teeth Not specified Effects of melatonin in wound healing of dental pulp and periodontium: Evidence from in vitro, in vivo and clinical studies. cited 9× melatonin Decreases - has been shown to reduce inflammation Human
— Not specified Effects of melatonin in wound healing of dental pulp and periodontium: Evidence from in vitro, in vivo and clinical studies. cited 9× melatonin Decreases - anti-inflammation inflammation Human
— Not provided The Potentials of Melatonin in the Prevention and Treatment of Bacterial Meningitis Disease. cited 9× melatonin Decreases - has a significant beneficial effect on inflammation inflammation Human
— Not specified The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review. cited 20× melatonin (MEL) Decreases - anti-inflammatory agent inflammation Human
— Not specified (wide range reported). Effects of Melatonin on Diabetic Neuropathy and Retinopathy. cited 14× melatonin Decreases - downregulates the overreaction of innate immune response inflammation Human
— Not specified Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality. cited 16× melatonin (MLT) Decreases - inhibiting inflammation Molecular
— — Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury. melatonin Decreases - may reduce inflammation Human
— — Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer's disease model. Melatonin Decreases - seems to reduce inflammation Human
patients suffering from insomnia disorder Not specified Sleep Immune Cross Talk and Insomnia. cited 23× melatonin Decreases - alleviates inflammation Human
— Not specified Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer. cited 3× melatonin Decreases - decreasing inflammation Molecular
cardiac cells Not specified Insight into the cardioprotective effects of melatonin: shining a spotlight on intercellular Sirt signaling communication. cited 1× melatonin Decreases - reduction of inflammation Molecular
— Not specified Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review. cited 5× melatonin No effect - impacts inflammation Molecular
— Not specified Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review. cited 5× melatonin (MEL) Decreases - reduced inflammation Animal
rats — The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta. melatonin Decreases - regulating inflammation inflammation Human
— Suggested effective cytoprotective dose: 100 mg/day; current clinical trial doses: 2-10 mg. Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant. cited 3× melatonin Decreases - demonstrated protective effects inflammation Human
— Not specified Unveiling the Protective Roles of Melatonin on Glial Cells in the Battle Against Alzheimer's Disease-Insights from In Vivo and In Vitro Studies. 
