The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta.
Journal of bioenergetics and biomembranes
October 1, 2024
Nazar M Shareef Mahmood et al. (3 authors)
Journal ArticleAnimal Study
Extracted Claims (24)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin (MEL) | decrease | blood pressure | rats | - | reduced | #1 |
melatonin (MEL) | decrease | heart rate | rats | - | reduced | #2 |
melatonin (MEL) | decrease | serum angiotensin II | rats | - | reduced | #3 |
melatonin (MEL) | increase | serum angiotensin-(1-7) | rats | - | increased | #4 |
melatonin (MEL) | increase | ACE2 activity | rats | - | increased | #5 |
melatonin (MEL) | increase | MT1 receptor expression | rats | - | increased | #6 |
melatonin (MEL) | increase | MT2 receptor expression | rats | - | increased | #7 |
melatonin (MEL) | increase | ACE2 expression | rats | - | increased | #8 |
melatonin (MEL) | decrease | angiotensin II type 1 receptor expression | rats | - | reduced | #9 |
melatonin (MEL) | increase | Mas receptor expression | rats | - | increased | #10 |
melatonin (MEL) | decrease | myocardial fibrosis | rats | - | reduced | #11 |
melatonin (MEL) | decrease | myocardial hypertrophy | rats | - | reduced | #12 |
melatonin (MEL) | decrease | myocardial apoptosis | rats | - | reduced | #13 |
melatonin (MEL) | increase | cardiac function | rats | - | improved | #14 |
melatonin (MEL) | decrease | oxidative stress | rats | - | reduced | #15 |
melatonin (MEL) | decrease | inflammation | rats | - | reduced | #16 |
melatonin (MEL) | decrease | myocardial injury | rats | - | reduced | #17 |
melatonin (MEL) | decrease | myocardial remodeling | rats | - | reduced | #18 |
melatonin (MEL) | decrease | myocardial dysfunction | rats | - | reduced | #19 |
melatonin (MEL) | decrease | myocardial damage | rats | - | reduced | #20 |
melatonin (MEL) | decrease | myocardial injury | rats | - | reduced | #21 |
melatonin (MEL) | decrease | myocardial remodeling | rats | - | reduced | #22 |
melatonin (MEL) | decrease | myocardial dysfunction | rats | - | reduced | #23 |
melatonin (MEL) | decrease | myocardial damage | rats | - | reduced | #24 |
Abstract
The current study explored melatonin (MEL) and its receptors, including MEL type 1 receptor (MT1) receptor and MEL type 2 receptor (MT2), along with the angiotensin-converting enzyme 2 (ACE
Medical Subject Headings (MeSH)
AnimalsMelatoninAngiotensin IIRatsDiabetes Mellitus, ExperimentalEndothelium, VascularMaleAortaAngiotensin-Converting Enzyme 2Rats, Wistar
Study Links
PubMed ID39083188
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