Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer's disease model.
IBRO neuroscience reports
June 1, 2023
Marcos K Andrade et al. (7 authors)
Journal ArticleHuman Study
Extracted Claims (8)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | neutral | circadian rhythms | - | - | can be associated with | #1 |
melatonin | neutral | aging | - | - | can be associated with | #2 |
melatonin | neutral | neuroprotection | - | - | can be associated with | #3 |
- | decrease | Melatonin levels | sporadic Alzheimer's disease (sAD) patients | - | decreased | #4 |
melatonin | decrease | inflammation | - | - | may reduce | #5 |
melatonin | decrease | oxidative stress | - | - | may reduce | #6 |
melatonin | decrease | TAU protein hyperphosphorylation | - | - | may reduce | #7 |
melatonin | decrease | formation of β-amyloid (Aβ) aggregates | - | - | may reduce | #8 |
Abstract
Melatonin is a hormone secreted by the pineal gland, it can be associated with circadian rhythms, aging and neuroprotection. Melatonin levels are decreased in sporadic Alzheimer's disease (sAD) patients, which suggests a relationship between the melatonergic system and sAD. Melatonin may reduce inflammation, oxidative stress, TAU protein hyperphosphorylation, and the formation of β-amyloid (Aβ) aggregates. Therefore, the objective of this work was to investigate the impact of treatment with 10 mg/kg of melatonin (i.p) in the animal model of
Study Links
PubMed ID36926592
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