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Evidence suggests Magnesium mayincreaseImmune function.
31 studies (32 claims)
Emerging evidence
Typical effective dose 300 (250–412.5) mgacross 4 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| arginine and magnesium | Increases - improve | inflammation, oxidative stress, endothelial function and blood pressure | Human | — | — | Benefits of Nut Consumption on Insulin Resistance and Cardiovascular Risk Factors: Multiple Potential Mechanisms of Actions. |
| Oral selenium and magnesium co-supplementation | Decreases - inhibited an increase | lipid and liver profile and liver function index induced by a high-fat diet | Animal | — | — | Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet. |
| both doses of selenium and magnesium co-supplementation | Decreases - notably decreased | liver function indexes ALT and AST | Animal | hyperlipidemic rat model | — | Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet. |
| oral magnesium (Mg) supplementation | No effect - might not improve | endothelial function (CRP level and FMD) | Human | hemodialysis (HD) patients | 440 mg of magnesium oxide, 3 times per week | Effect of magnesium supplementation on carotid intima-media thickness and flow-mediated dilatation among hemodialysis patients: a double-blind, randomized, placebo-controlled trial.cited 72× |
| oral magnesium supplementation | No effect - No significant differences | lung function | Human | COPD patients | — | Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients.cited 21× |
| Magnesium dititanate (MgTi2O5) nanoparticles | Increases - improved | mitochondrial function | HumanMolecular | human endothelial cells | — | Magnesium dititanate (MgTi |
| daily intake of a homotaurine, carnosine, forskolin, vitamins B1, B2, and B6, folic acid, and magnesium based supplement (GANGLIOLIFE®) | Increases - improved | visual function | Human | patients with progressive POAG despite good tonometric compensation | 2 tablets/day for the first 2 months, then 1 tablet/day for the next 4 months (exact Vitamin B6 dosage not specified). | Assessing the Performance of Daily Intake of a Homotaurine, Carnosine, Forskolin, Vitamin B2, Vitamin B6, and Magnesium Based Food Supplement for the Maintenance of Visual Function in Patients with Primary Open Angle Glaucoma.cited 10× |
| magnesium isoglycyrrhizinate | Increases - general liver protection methods to improve | hepatic function | Human | 90-year-old female patient | 456 mg, 3 times daily. | Sacubitril/valsartan-induced liver injury: A case report and literature review.cited 1× |
| magnesium therapy | No effect - seems to be safe | liver function | Human | patients with moderate atherosclerotic plaque | 300 mg MgSO4 daily. | Magnesium Sulfate Administration in Moderate Coronary Artery Disease Patients Improves Atherosclerotic Risk Factors: A Double-Blind Clinical Trial Study.cited 6× |
| magnesium supplementation | Increases - improves | bladder function | HumanMolecular | overactive bladder (OAB) patients | Not available | Big-conductance Cacited 7× |
| magnesium supplementation | No effect - were also not different | Changes in reactive hyperemia index, retinal microvascular caliber and plasma markers for microvascular endothelial function (sVCAM-1, sICAM-1 and sE-selectin) | Human | overweight and obese subjects | 350 mg daily (three times daily dosing). | Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults.cited 31× |
| a daily magnesium supplement of 350 mg for 24 weeks | No effect - does not improve | endothelial function and cardiometabolic risk markers | Human | overweight and obese middle-aged and elderly adults | 350 mg daily (three times daily dosing). | Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults.cited 31× |
| Magnesium supplementation | Increases - significantly improved | endothelial function | Human | patients with metabolic syndrome | — | Synergistic effects of |
| magnesium supplementation | Increases - improved | endothelial function | Human | thiazide-treated hypertensive women | 600 mg/day (magnesium chelate) | Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women.cited 45× |
| magnesium supplementation | Increases - was shown to improve | endothelial function | HumanMolecular | — | Not specified | Effects of Magnesium on the Phosphate Toxicity in Chronic Kidney Disease: Time for Intervention Studies.cited 31× |
| magnesium supplementation | No effect - did not affect | ex vivo monocyte function | Human | adults with insulin-treated type 2 diabetes and low magnesium levels | 15 mmol/day | Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels.cited 4× |
| magnesium supplementation | Decreases - changes in | homeostasis model of assessment-estimated β-cell function | Human | women with GDM | 250 mg magnesium oxide daily. | Retracted: Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial.cited 50× |
| magnesium supplementation | Increases - A significant improvement was observed | pulmonary function | Human | patients with cystic fibrosis (CF) | Not specified for choline alone. | Antioxidant Micronutrients and Essential Fatty Acids Supplementation on Cystic Fibrosis Outcomes: A Systematic Review.cited 8× |
| magnesium supplementation | Increases - efficacy on renal function | renal function | Human | patients with CKD | Not specified | Magnesium: An old player revisited in the context of CKD-MBD.cited 10× |
| 250 mg magnesium in the form of magnesium oxide daily for 8 weeks | No effect - do not lead to a significant greater gain | muscle strength and function | Human | 74 healthy middle-aged overweight women (25 ≤ BMI ≤ 30 kg/m²) | 250 mg magnesium (as magnesium oxide) daily. | Does magnesium supplementation improve body composition and muscle strength in middle-aged overweight women? A double-blind, placebo-controlled, randomized clinical trial.cited 30× |
| vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) co-supplementation | Increases - could improve | behavioral function | Human | children with ADHD | — | The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial.cited 23× |
| Magnesium | Increases - improved | cardiac function | AnimalMolecular | ISO-induced HF rats | Not specified | Magnesium-assisted hydrogen improves isoproterenol-induced heart failure. |
| Magnesium | Increases - improves | human endothelial function | Human | — | Not specified | Magnesium and cardiovascular system.cited 86× |
| Magnesium | Decreases - inhibits | platelet function | Human | — | Not specified | Magnesium and cardiovascular system.cited 86× |
| magnesium | No effect - vital for | muscle function | Human | COPD patients | Not specified | The Role of Trace Elements in COPD: Pathogenetic Mechanisms and Therapeutic Potential of Zinc, Iron, Magnesium, Selenium, Manganese, Copper, and Calcium.cited 2× |
| Vitamin D and Magnesium (Mg) | Increases - beneficial effects | muscle protein synthesis, muscle strength, and/or muscle function | Human | middle-aged and older females | Not specified | Nutrition Interventions on Muscle-Related Components of Sarcopenia in Females: A Systematic Review of Randomized Controlled Trials.cited 6× |
| magnesium administration | Increases - could improve | parameters of vascular function and calcification and mineral metabolism | Human | people with CKD | Daily dosage of elemental magnesium varied highly between studies (not specified). | Magnesium Administration in Chronic Kidney Disease.cited 18× |
| magnesium hydroxide | No effect - will be assessed for | proportion of patients with a score of < 30 on the Bowel Function Index (BFI) | Human | patients with incurable cancer starting with opioids for pain management | Not specified in the abstract. | Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study).cited 1× |
| magnesium deficiency | Decreases - appear to play a role | physical function | Human | twenty consecutive female patients with FM | Not available | Role of micronutrients in the symptoms of fibromyalgia: a review of the literature and analysis of an Italian female sample.cited 1× |
| magnesium supplements | No effect - showed no beneficial effect | BP, vascular function and glycolipid profile | Human | young men with a family history of MetS/T2DM | 8.1 mmol of magnesium-pidolate twice daily. | Effects of magnesium supplements on blood pressure, endothelial function and metabolic parameters in healthy young men with a family history of metabolic syndrome.cited 47× |
| magnesium-L-threonate | No effect - did not show improvement | cognitive function | Human | patients who underwent breast cancer procedure | Not specified in the abstract. | A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Therapeutic Effect of Magnesium-L-Threonate Supplementation for Persistent Pain After Breast Cancer Surgery.cited 1× |
| Compound Danshen injection combined with magnesium sulfate | Increases - improve | coagulation function | Human | patients with PIH syndrome | Not specified | Effects of Compound Danshen Injection Combined with Magnesium Sulfate on Pregnancy-Induced Hypertension Syndrome under the Guidance of Empirical Mode Decomposition Algorithm-Based Ultrasound Image.cited 5× |