Magnesium: An old player revisited in the context of CKD-MBD.
Study Goal
The researchers aimed to evaluate the role of metallic elements like calcium in managing CKD-MBD (chronic kidney disease-mineral and bone disorder).
Results Summary
The abstract suggests that calcium-based P binders are among the strategies studied to mitigate CKD-MBD progression, but the focus shifts to magnesium's potential benefits, with no specific results reported for calcium.
Population
Patients with chronic kidney disease (CKD) and associated mineral and bone disorders (CKD-MBD).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
aluminum-based P binders | decrease | CKD-MBD progression | patients with CKD | - | strategies to avoid, reduce, or slow down CKD-MBD progression | #1 |
magnesium-based P binders | decrease | CKD-MBD progression | patients with CKD | - | strategies to avoid, reduce, or slow down CKD-MBD progression | #2 |
calcium-based P binders | decrease | CKD-MBD progression | patients with CKD | - | strategies to avoid, reduce, or slow down CKD-MBD progression | #3 |
magnesium | decrease | CKD-MBD | patients with CKD | - | has been used to treat CKD-MBD | #4 |
magnesium supplementation | decrease | vascular calcification | patients with CKD | - | efficacy on vascular calcification | #5 |
magnesium supplementation | increase | renal function | patients with CKD | - | efficacy on renal function | #6 |
magnesium supplementation | decrease | bone disorders | patients with CKD | - | efficacy on bone disorders | #7 |
magnesium | decrease | CKD-MBD | patients with CKD | - | potential beneficial effects in the management of CKD-MBD | #8 |
Chronic kidney disease (CKD) is associated with a wide number of abnormalities in mineral metabolism. Often, these alterations are the leading players in the development of comorbidities associated with CKD, which are risk factors of mortality. In this context, mineral and bone disorder associated with CKD (CKD-MBD) are highlighted, connecting bone, renal, and cardiovascular disorders. Many studies have been led to propose strategies to avoid, reduce, or slow down CKD-MBD progression using different compositions of metallic elements-based P binders such as aluminum, magnesium, or calcium. Magnesium, the aim of this review, has been used by nephrologists to treat CKD-MBD with a variable acceptation due mainly to different results on bone homeostasis. Nowadays, we have new evidence about the efficacy of magnesium supplementation on vascular calcification, renal function, and bone disorders, suggesting potential beneficial effects of Magnesium in the management of CKD-MBD.