Big-conductance Ca
Channels (Austin, Tex.)
January 1, 1970
Shankar P Parajuli et al. (4 authors)
Journal ArticleReviewHuman StudyMolecular Study
Study Details
Study Goal
The researchers were attempting to determine the role of ion channels, including big-conductance Ca, in regulating contractile responses in urinary bladder smooth muscle cells (UBSMCs).
Results Summary
The abstract does not provide specific findings regarding Inositol's effects, only mentioning the regulation of UBSMC contractions by ion channels.
Population
Urinary bladder smooth muscle cells (UBSMCs)
Effective Dosage
Not available
Duration
Not available
Interactions
None mentioned
Extracted Claims (5)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
big-conductance Ca²⁺-activated K⁺ (BK) channel activation | increase | UBSMC relaxation | urinary bladder smooth muscle cells (UBSMCs) | - | induces | #1 |
BK channel inhibition | increase | UBSMC contractility | urinary bladder smooth muscle cells (UBSMCs) | - | increases | #2 |
magnesium supplementation | increase | BK channel activity | urinary bladder smooth muscle cells (UBSMCs) | - | enhances | #3 |
magnesium supplementation | decrease | UBSMC contractility | urinary bladder smooth muscle cells (UBSMCs) | - | reduces | #4 |
magnesium supplementation | increase | bladder function | overactive bladder (OAB) patients | - | improves | #5 |
Abstract
Contraction and relaxation of urinary bladder smooth muscle cells (UBSMCs) represent the important physiological functions of the bladder. Contractile responses in UBSMCs are regulated by a number of ion channels including big-conductance Ca
Medical Subject Headings (MeSH)
AnimalsHumansInositol 1,4,5-Trisphosphate ReceptorsLarge-Conductance Calcium-Activated Potassium ChannelsMyocytes, Smooth MuscleReceptors, MuscarinicRyanodine Receptor Calcium Release ChannelUrinary Bladder
Study Links
PubMed ID27101440
Quality Scores
SafetyNot Assessed
Citation Metrics
Total Citations7
Citations/Year0.8
Relative Citation Ratio0.39
NIH Percentile20.8%
Research Impact Scores
APT Score0.05
Related Supplements