Creatine
→Lean mass

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Evidence suggests Creatine mayincreaseLean mass.

10 studies (15 claims)

Moderate consensus

Study Claims

15 of 15

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
one-year low-dose creatine supplementation (1g/d)	No effect - No significant changes	body lean mass	Human	older postmenopausal women	1g/d	Effects of long-term low-dose dietary creatine supplementation in older women.cited 41×
creatine monohydrate supplementation and resistance training	Increases - improves	measures of lean mass	Human	older adults	Not specified	Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults?cited 3×
creatine supplementation with resistance training	Increases - showed greater accrual	appendicular lean mass	Human	vulnerable older women	Not specified in the abstract.	Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial.cited 72×
creatine supplementation combined with resistance training	Increases - improved	appendicular lean mass	Human	older vulnerable women	Not specified in the abstract.	Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial.cited 72×
creatine supplementation	Increases - changes	appendicular lean mass	Human	vulnerable older women	Not specified in the abstract.	Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial.cited 72×
creatine supplementation	Increases - experienced comparable gains	appendicular lean mass	Human	vulnerable older women	Not specified in the abstract.	Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial.cited 72×
creatine (CR) supplementation combined with strengthening exercises	Increases - presented a significant improvement	lower limb lean mass	Human	postmenopausal women with knee OA	20 g/day for 1 week, then 5 g/day thereafter	Beneficial effect of creatine supplementation in knee osteoarthritis.cited 43×
continuous and daily low-dose creatine supplementation combined with at least 12 weeks of resistance training	Increases - would require	additive ergogenic creatine effects on upper and/or lower body strength, functional capacity, and lean mass	Human	older population	Continuous and daily low-dose creatine (specific amount not stated).	The Additive Effects of Creatine Supplementation and Exercise Training in an Aging Population: A Systematic Review of Randomized Controlled Trials.cited 16×
creatine supplementation combined with exercise	Increases - additive ergogenic creatine effects	upper and/or lower body strength, functional capacity, and lean mass	Human	older population	Continuous and daily low-dose creatine (specific amount not stated).	The Additive Effects of Creatine Supplementation and Exercise Training in an Aging Population: A Systematic Review of Randomized Controlled Trials.cited 16×
creatine supplementation	No effect - there were no significant changes	lean mass	Human	C-SLE patients with mild disease activity	0.1 g/kg/day	Efficacy and safety of creatine supplementation in childhood-onset systemic lupus erythematosus: a randomized, double-blind, placebo-controlled, crossover trial.cited 18×
creatine supplementation	Increases - can improve	lean mass and muscle function	Human	older populations	Not specified	Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain.cited 67×
creatine	Increases - appears to be applicable	lean mass and muscle function	Human	older individuals regardless of sex, fitness or health status	Not specified	Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain.cited 67×
Creatine	Increases - further increasing	lean mass	Human	—	Not specified	Dietary Amino Acids and Immunonutrition Supplementation in Cancer-Induced Skeletal Muscle Mass Depletion: A Mini-Review.cited 42×
whey protein and creatine supplementation	Increases - increased	DXA lean mass	Human	resistance-trained women	24 g whey protein (PRO group) or 24 g whey protein plus 5 g creatine monohydrate (PRO + CRE group) post-exercise.	A Pilot Study Examining the Effects of 8-Week Whey Protein versus Whey Protein Plus Creatine Supplementation on Body Composition and Performance Variables in Resistance-Trained Women.cited 5×
oral creatine (Cr) supplementation	Increases - increased	appendicular lean mass (ALM; a surrogate measure of muscle mass)	Human	RA patients	Not specified (only duration mentioned).	Can Creatine Supplementation Improve Body Composition and Objective Physical Function in Rheumatoid Arthritis Patients? A Randomized Controlled Trial.cited 30×