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Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults?

Current osteoporosis reports
November 1, 2024
Darren G Candow et al. (2 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the potential benefits of creatine monohydrate supplementation in counteracting age-related sarcopenia, including its effects on muscle mass, strength, functional ability, cognitive function, and bone health in older adults.

Results Summary

The study found that creatine monohydrate supplementation, combined with resistance training, improved lean mass, muscle thickness, strength, and functional ability in older adults. While some cognitive benefits were noted, creatine showed minimal impact on bone mass.

Population

Older adults experiencing age-related sarcopenia.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (7)
InterventionDirectionEndpointPopulationDosageImpactClaim #
creatine monohydrate supplementation and resistance training
increase
measures of lean mass
older adults
-
improves
#1
creatine monohydrate supplementation and resistance training
increase
regional (limb) muscle thickness
older adults
-
improves
#2
creatine monohydrate supplementation and resistance training
increase
upper- and lower-body muscle strength
older adults
-
improves
#3
creatine monohydrate supplementation and resistance training
increase
functional ability
older adults
-
improves
#4
creatine (supplementation or habitual diet)
increase
some aspects of cognitive function
-
-
provides a ray of 'hope' for improving
#5
creatine
no change
measures of bone mass
older adults
-
is more 'hype' than 'hope' for improving
#6
creatine monohydrate supplementation
neutral
-
older adults
-
provides some anti-sarcopenic benefits for
#7
Abstract

PURPOSE OF REVIEW: Sarcopenia, generally characterized by the age-related reduction in muscle strength, lean/muscle mass and functional ability, is also associated with reduced bone mass and strength and impaired brain health and function. One potential intervention which has received much 'hype' over the past few decades to countermeasure these negative consequences of biological aging is creatine monohydrate supplementation. RECENT FINDINGS: From a skeletal muscle perspective, the combination of creatine monohydrate supplementation and resistance training provides 'hope' for older adults as it improves measures of lean mass, regional (limb) muscle thickness, upper- and lower-body muscle strength and functional ability. Further, there is some evidence that creatine (supplementation or habitual diet) provides a ray of 'hope' for improving some aspects of cognitive function. The majority of research suggests that creatine is more 'hype' than 'hope' for improving measures of bone mass in older adults. Creatine monohydrate supplementation provides some anti-sarcopenic benefits for older adults.

Medical Subject Headings (MeSH)
HumansCreatineDietary SupplementsMuscle, SkeletalSarcopeniaMuscle StrengthAgedBrainBone DensityResistance TrainingAgingCognition
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality80/10
Citation Metrics
Total Citations3
Citations/Year3.0
Research Impact Scores
APT Score0.25
Weight Score2.77
Normalized Score0.66
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