9
14
10
↑9
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—10
Evidence suggests Caffeine maydecreaseTime to fatigue.
26 studies (33 claims)
Conflicting evidence
Typical effective dose 9 (6–100) mgacross 9 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| caffeine supplementation | Decreases - delaying the negative effects of fatigue | fatigue | Human | athletes | — | Acute Effects of Caffeine on Overall Performance in Basketball Players-A Systematic Review.cited 9× |
| caffeine supplementation | No effect - had no effect | fatigue index | Human | physically active individuals | — | Effect of Caffeine Supplementation on Quadriceps Performance After Eccentric Exercise.cited 5× |
| caffeine supplementation | No effect - had not found differences between sexes | fatigue index | Human | men and women athletes | — | Effect of Caffeine Supplementation on Sports Performance Based on Differences Between Sexes: A Systematic Review.cited 73× |
| caffeine supplementation | No effect - without affecting | fatigue levels in the lower limbs | Human | Olympic-level boxers | — | Caffeine Supplementation Improves Anaerobic Performance and Neuromuscular Efficiency and Fatigue in Olympic-Level Boxers.cited 41× |
| caffeine supplementation | Decreases - reduction in fatigue perception | fatigue perception | Human | non-athlete subjects | — | Effect of acute caffeine supplementation before intermittent high-intensity exercise on cytokine levels and psychobiological parameters: A randomized, cross-over, placebo-controlled trial.cited 1× |
| caffeine-containing supplement | Increases - resulted in a significant increase | fatigue | Human | recreationally active men | — | Acute Effects of a Caffeine-Containing Supplement on Anaerobic Power and Subjective Measurements of Fatigue in Recreationally Active Men.cited 14× |
| caffeine-containing supplement | Decreases - improved | perceived measures of fatigue | Human | recreationally active men | — | Acute Effects of a Caffeine-Containing Supplement on Anaerobic Power and Subjective Measurements of Fatigue in Recreationally Active Men.cited 14× |
| caffeine beverage | Decreases - may be beneficial for reducing | perceived fatigue during acute anaerobic exercise | Human | — | — | Acute Effects of a Caffeine-Containing Supplement on Anaerobic Power and Subjective Measurements of Fatigue in Recreationally Active Men.cited 14× |
| caffeine-containing supplement (CAF) | Decreases - reported less fatigue | perceived feelings of fatigue | Human | male golfers with a United States Golf Association handicap of 3-10 | 1.9 ± 0.3 mg/kg, consumed before and after nine holes during each 18-hole round. | Effect of Caffeine on Golf Performance and Fatigue during a Competitive Tournament.cited 16× |
| moderate dose (1.9 ± 0.3 mg · kg(-1)) of caffeine | Decreases - reduces | fatigue | Human | skilled golfers | 1.9 ± 0.3 mg/kg, consumed before and after nine holes during each 18-hole round. | Effect of Caffeine on Golf Performance and Fatigue during a Competitive Tournament.cited 16× |
| multi-ingredient supplement containing 400 mg/d PS and 100 mg/d caffeine (supplement [SUP]) | Decreases - appears to attenuate | perception of fatigue | Human | recreationally trained individuals | 100 mg/d caffeine | Phosphatidylserine and caffeine attenuate postexercise mood disturbance and perception of fatigue in humans.cited 13× |
| caffeine (80 mg) and taurine (1 g) | No effect - unclear, trivial | intersprint fatigue index | Human | 11 male subjects (age 21 ± 2 years; stature 178 ± 7 cm; body mass 80 ± 13 kg) | 80 mg caffeine and 1 g taurine, administered once | Energy Drink Doses of Caffeine and Taurine Have a Null or Negative Effect on Sprint Performance.cited 13× |
| caffeine (80 mg) and taurine (1 g) | Increases - greater | intrasprint fatigue | Human | 11 male subjects (age 21 ± 2 years; stature 178 ± 7 cm; body mass 80 ± 13 kg) | 80 mg caffeine and 1 g taurine, administered once | Energy Drink Doses of Caffeine and Taurine Have a Null or Negative Effect on Sprint Performance.cited 13× |
| caffeine and taurine at doses equivalent to commercial energy drinks | Increases - seemed to induce greater fatigue | fatigue within selected sprints | Human | 11 male subjects (age 21 ± 2 years; stature 178 ± 7 cm; body mass 80 ± 13 kg) | 80 mg caffeine and 1 g taurine, administered once | Energy Drink Doses of Caffeine and Taurine Have a Null or Negative Effect on Sprint Performance.cited 13× |
| oral caffeine ingestion | Increases - enhances | fatigue resistance | Human | — | 6 mg/kg body weight | Caffeine intake improves intense intermittent exercise performance and reduces muscle interstitial potassium accumulation.cited 109× |
| caffeine capsules (3 mg/kg, 6 mg/kg, 9 mg/kg) | No effect - did not differ | fatigue index | Human | twelve active males | 3 mg/kg (LOW), 6 mg/kg (MOD), 9 mg/kg (HIGH), ingested once 1 hour before exercise | Dose-response effects of caffeine during repeated cycling sprints in normobaric hypoxia to exhaustion. |
| acute low-dose caffeine supplementation | Increases - significantly increased | electromyographic fatigue threshold (EMGFT) | Human | 10 physically active men | 200 mg (single dose) | Acute Low-Dose Caffeine Supplementation Increases Electromyographic Fatigue Threshold in Healthy Men.cited 10× |
| acute low-dose caffeine supplementation | Decreases - delays | neuromuscular fatigue | Human | — | 200 mg (single dose) | Acute Low-Dose Caffeine Supplementation Increases Electromyographic Fatigue Threshold in Healthy Men.cited 10× |
| low dose of caffeine (CAF) | No effect - had no effect | cognitive measures following physical fatigue | Human | n = 11 | 500 mg GUA (containing 130 mg caffeine) and 100 mg CAF, administered once. | Effects of Acute Guarana (Paullinia cupana) Ingestion on Mental Performance and Vagal Modulation Compared to a Low Dose of Caffeine. |
| caffeine consumption | Increases - significantly higher mean values | physical working capacity at the fatigue threshold (PWCFT) | Human | 8 healthy college-aged men | Not specified in the abstract. | Caffeine Expectancy Does Not Influence the Physical Working Capacity at the Fatigue Threshold. |
| caffeine consumption | No effect - no statistically significant mean differences | physical working capacity at the fatigue threshold (PWCFT) | Human | 8 healthy college-aged men | Not specified in the abstract. | Caffeine Expectancy Does Not Influence the Physical Working Capacity at the Fatigue Threshold. |
| caffeine ingestion | Decreases - tendency for reduced | fatigue (POMS) | Human | female team-game players taking low-dose monophasic oral contraceptives | 6 mg/kg anhydrous caffeine, single dose. | Caffeine ingestion enhances perceptual responses during intermittent exercise in female team-game players.cited 30× |
| caffeine | No effect - No effects were found | agility tests performed after fatigue | Human | adult female TSA | — | Does Acute Caffeine Supplementation Improve Physical Performance in Female Team-Sport Athletes? Evidence from a Systematic Review and Meta-Analysis.cited 25× |
| caffeine | Decreases - reduced | fatigue | Human | volunteers | 200 mg of caffeine (single dose). | Effects of 2 adenosine antagonists, quercetin and caffeine, on vigilance and mood.cited 22× |
| caffeine | Increases - significantly increased | fatigue index | Human | fifteen healthy male (n = 8) and female (n = 7) participants | Not specified | Effect of a Multi-Nutrient Over-the-Counter Supplement on Changes in Metabolic Rate and Markers of Lipolysis.cited 5× |
| caffeine | Decreases - reduced | feelings of fatigue | Human | 24-hour caffeine deprived habitual caffeine consumers | 200 mg caffeine, 2000 mg taurine, and 50 g glucose, administered in various combinations. | Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.cited 85× |
| caffeine (CAF) | Decreases - reverted | mental fatigue-induced increase in EEG theta wave | Human | — | — | Caffeine improved cycling trial performance in mentally fatigued cyclists, regardless of alterations in prefrontal cortex activation.cited 49× |
| caffeine (5 mg·kg⁻¹) | Increases - increases | neuromuscular fatigue | Human | cyclists | — | Caffeine increases peripheral fatigue in low- but not in high-performing cyclists.cited 11× |
| caffeine | Decreases - reduced | peripheral fatigue | Human | Fourteen men [age (means ± SD): 26 ± 6 yr] | — | No additive effect of acetaminophen when co-ingested with caffeine on cycling performance in well-trained young men.cited 7× |
| caffeine | No effect - no difference was observed | time to fatigue test | Human | soccer players | — | Effects of Caffeine Supplementation on Physical Performance of Soccer Players: Systematic Review and Meta-Analysis.cited 14× |