Phosphatidylserine and caffeine attenuate postexercise mood disturbance and perception of fatigue in humans.
Study Goal
The researchers aimed to determine whether a supplement containing caffeine and phosphatidylserine could attenuate post-exercise fatigue and maintain cognitive function and mood in recreationally trained individuals.
Results Summary
The study found that the supplement did not significantly affect reaction time or cognitive function but attenuated post-exercise perception of fatigue and mood scores compared to the control.
Population
Recreationally trained individuals
Effective Dosage
100 mg/d caffeine
Duration
2 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
multi-ingredient supplement containing 400 mg/d PS and 100 mg/d caffeine (supplement [SUP]) | decrease | postexercise MD scores | recreationally trained individuals | - | appears to attenuate | #1 |
multi-ingredient supplement containing 400 mg/d PS and 100 mg/d caffeine (supplement [SUP]) | decrease | perception of fatigue | recreationally trained individuals | - | appears to attenuate | #2 |
multi-ingredient supplement containing 400 mg/d PS and 100 mg/d caffeine (supplement [SUP]) | no change | CF | recreationally trained individuals | - | does not affect | #3 |
multi-ingredient supplement containing 400 mg/d PS and 100 mg/d caffeine (supplement [SUP]) | no change | RT | recreationally trained individuals | - | does not affect | #4 |
Phosphatidylserine (PS) | decrease | pre- to postexercise perception of fatigue | - | - | significantly attenuated | #5 |
- | decrease | RT performance in the 60-second reaction drill | - | - | significant decrease | #6 |
- | increase | performance of the serial subtraction test | - | - | significant increase | #7 |
- | increase | number of correct answers | - | 8.9% and 7.1% | significant increase | #8 |
- | decrease | time to answer | - | 8.0% and 7.5% | significant decrease | #9 |
control (CON) | increase | total MD score | - | - | significant increase | #10 |
Phosphatidylserine (PS) | no change | total MD score | - | - | not for | #11 |
Phosphatidylserine (PS) may attenuate the adverse effects of physical fatigue. Therefore, we investigated the effects of a multi-ingredient supplement containing 400 mg/d PS and 100 mg/d caffeine (supplement [SUP]) for 2 weeks on measures of cognitive function (CF), reaction time (RT), and mood (MD) following an acute exercise stress. It is hypothesized that PS will maintain preexercise CF and RT scores, while attenuating postexercise fatigue. Participants completed 2 acute bouts of resistance exercise (T1 and T2) separated by 2-week ingestion of SUP or control (CON). Outcome measures were assessed pre- and postexercise. When collapsed across groups, a significant decrease in RT performance was seen in the 60-second reaction drill from pre- to postexercise at T1. All other RT tests were similar from pre- to postexercise at T1. Reaction time was not significantly changed by PS. When collapsed across groups, a significant increase in performance of the serial subtraction test was seen. A significant increase (8.9% and 7.1%) in the number of correct answers and a significant decrease (8.0% and 7.5%) in time to answer were seen from pre- to postworkout at T1 and T2, respectively. A significant increase in total MD score from pre- to postworkout was observed for CON but not for PS at T2. Phosphatidylserine significantly attenuated pre- to postexercise perception of fatigue compared to CON. Ingestion of SUP for 14 days appears to attenuate postexercise MD scores and perception of fatigue, but does not affect CF or RT, in recreationally trained individuals.