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Evidence suggests Melatonin mayincreaseBone strength.
8 studies (8 claims)
Emerging evidence
Typical effective dose 3 (3–3) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| Melatonin | Increases - increases | bone strength | AnimalMolecular | ovariectomized rats | Not provided in the abstract. | Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis.cited 23× |
| melatonin | Increases - increased | bone strength | AnimalMolecular | ovariectomized rats | — | Melatonin membrane receptors MT |
| Melatonin | No effect - evaluated treatments included | correcting oxidative stress parameters, enhancing exogenous antioxidant capacity, modifying electrocardiographic abnormalities, and improving heart contraction strength | Human | — | Not specified | Discovering the most impactful treatments for aluminum phosphide cardiotoxicity gleaned from systematic review of animal studies. |
| Melatonin | No effect - evaluated treatments included | correcting oxidative stress parameters, enhancing exogenous antioxidant capacity, modifying electrocardiographic abnormalities, and improving heart contraction strength | Human | — | Not specified | Discovering the most impactful treatments for aluminum phosphide cardiotoxicity gleaned from systematic review of animal studies. |
| melatonin | Increases - increase | muscle strength | Human | patients with sarcopenia | Not specified | The role of melatonin in sarcopenia: Advances and application prospects.cited 11× |
| melatonin | No effect - no significant changes were observed | muscle strength in lower extremities | Human | postmenopausal women with osteopenia | 1 mg or 3 mg nightly. | The effect of melatonin treatment on postural stability, muscle strength, and quality of life and sleep in postmenopausal women: a randomized controlled trial.cited 41× |
| melatonin | No effect - no significant changes were observed | muscle strength in upper extremities | Human | postmenopausal women with osteopenia | 1 mg or 3 mg nightly. | The effect of melatonin treatment on postural stability, muscle strength, and quality of life and sleep in postmenopausal women: a randomized controlled trial.cited 41× |
| melatonin | Increases - work in concert with oxytocin to enhance | strength of uterine contractions | Human | — | Not specified | Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology.cited 198× |
| 4-week intervention of melatonin and essential aminoacid supplementation | No effect - No significant changes | strength | Human | 159 elderly sarcopenic patients | 4 g EAA daily. | Is a Combination of Melatonin and Amino Acids Useful to Sarcopenic Elderly Patients? A Randomized Trial.cited 6× |
| intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation | Increases - improved | muscle strength | Human | hemodialysis (HD) patients | Not specified | Effects of intradialytic exercise in combination with melatonin supplementation on functional capacity, postural balance, and quality of life in hemodialysis patients.cited 2× |