Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis.
International journal of molecular sciences
January 1, 1970
Iona J MacDonald et al. (6 authors)
Journal ArticleReviewAnimal StudyMolecular Study
Study Details
Study Goal
The researchers were attempting to determine the role of melatonin in the bone turnover cycle and its potential impact on bone-wasting diseases.
Results Summary
The abstract does not provide specific findings regarding melatonin's effects on bone turnover or bone-wasting diseases.
Population
Not specified in the abstract.
Effective Dosage
Not provided in the abstract.
Duration
Not specified in the abstract.
Interactions
None mentioned
Extracted Claims (8)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Melatonin | increase | osteoblast differentiation | in vitro cell cultures | - | promotes | #1 |
Melatonin | decrease | osteoclast differentiation | in vitro cell cultures | - | inhibits | #2 |
Melatonin | increase | bone mass | ovariectomized rats | - | increases | #3 |
Melatonin | increase | bone mineral density | ovariectomized rats | - | increases | #4 |
Melatonin | increase | bone strength | ovariectomized rats | - | increases | #5 |
Melatonin | decrease | bone loss | postmenopausal women | - | reduces | #6 |
Melatonin | increase | bone mineral density | postmenopausal women | - | improves | #7 |
Melatonin | decrease | bone turnover markers | postmenopausal women | - | reduces | #8 |
Abstract
Osteoblasts and osteoclasts are major cellular components in the bone microenvironment and they play a key role in the bone turnover cycle. Many risk factors interfere with this cycle and contribute to bone-wasting diseases that progressively destroy bone and markedly reduce quality of life. Melatonin (
Medical Subject Headings (MeSH)
AnimalsAntioxidantsBone NeoplasmsHumansMelatoninOsteoclastsOsteogenesisOsteoporosis
Study Links
PubMed ID34502344
Quality Scores
SafetyNot Assessed
Citation Metrics
Total Citations23
Citations/Year5.8
Relative Citation Ratio2.25
NIH Percentile77.9%
Research Impact Scores
APT Score0.50
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