Effects of intradialytic exercise in combination with melatonin supplementation on functional capacity, postural balance, and quality of life in hemodialysis patients.
Study Goal
The researchers aimed to determine whether combining intradialytic concurrent training with melatonin supplementation improves functional capacity, muscle strength, postural balance, and quality of life in hemodialysis patients.
Results Summary
Melatonin combined with exercise improved postural balance in dual-task conditions and some quality-of-life domains more than exercise alone, while both exercise groups showed benefits in functional capacity, muscle strength, and postural balance.
Population
Hemodialysis patients
Effective Dosage
Not specified
Duration
12 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation | increase | functional capacity | hemodialysis (HD) patients | - | improved | #1 |
intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation | increase | muscle strength | hemodialysis (HD) patients | - | improved | #2 |
intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation | increase | quality of life (QoL) | hemodialysis (HD) patients | - | improved | #3 |
intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation | increase | postural balance parameters in eyes open and eyes closed conditions | hemodialysis (HD) patients | - | improved | #4 |
intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation | increase | postural balance parameters in the dual task condition | hemodialysis (HD) patients | - | improved | #5 |
intradialytic concurrent (resistance-endurance) training | increase | physical function, muscle strength, postural balance, and QoL | HD patients | - | induced beneficial effects | #6 |
MEL supplementation combined with intradialytic exercise | increase | postural balance and QoL | - | - | lead to better improvements | #7 |
INTRODUCTION: We evaluated the effect of intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation on functional capacity, muscle strength, postural balance, and quality of life (QoL) in hemodialysis (HD) patients. METHODS: Thirty-three HD patients were randomized into three groups: Exercise (EX)-MEL (n = 11); EX-Placebo (PLA) (n = 11) and Control (C)-PLA (n = 11). Participants included in the EX-MEL and EX-PLA groups were submitted to concurrent training for 12 weeks. RESULTS: EX-MEL and EX-PLA improved functional capacity, muscle strength, QoL, and postural balance parameters in eyes open and eyes closed conditions. Parameters of postural balance in the dual task condition were improved only in EX-MEL. EX-MEL induced better results in some domains of QoL compared with EX-PLA. CONCLUSION: Intradialytic concurrent training induced beneficial effects on physical function, muscle strength, postural balance, and QoL in HD patients. MEL supplementation combined with intradialytic exercise lead to better improvements in postural balance and QoL.