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13
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Evidence suggests Magnesium maydecreaseDepression.
17 studies (18 claims)
Moderate consensus
Typical effective dose 400 (287–500) mgacross 4 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| magnesium and zinc | Decreases - significantly reduced | Beck Depression Inventory index (BDI) | Human | patients suffering from coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) | — | The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease.cited 41× |
| magnesium orotate | No effect - adding | psychiatric disorders' treatment, such as major depression and anxiety | Human | — | Not specified | Magnesium Orotate and the Microbiome-Gut-Brain Axis Modulation: New Approaches in Psychological Comorbidities of Gastrointestinal Functional Disorders.cited 20× |
| magnesium ions (120 mg/day as magnesium aspartate) | No effect - showed no significant differences | Hamilton Depression Rating Scale (HDRS) scores | Human | participants with recurrent depressive disorder who developed a depressive episode | — | Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response.cited 22× |
| higher intake of dietary magnesium | Decreases - seems to be associated with lower | depression symptoms | Human | humans | Not specified. | Magnesium and depression: a systematic review.cited 72× |
| oral magnesium supplementation | Decreases - may prevent | depression | Human | — | Not specified. | Magnesium and depression: a systematic review.cited 72× |
| oral magnesium supplementation | Decreases - might be used as an adjunctive therapy for | depression | Human | — | Not specified. | Magnesium and depression: a systematic review.cited 72× |
| magnesium | Decreases - seems to be effective in the treatment of | depression | Human | — | Not specified. | Magnesium and depression: a systematic review.cited 72× |
| vitamin D and/or magnesium supplementation | Decreases - significant reduction | depression score | Human | obese women with mild to moderate depressive symptoms | — | Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms.cited 21× |
| magnesium preparations | No effect - seem to be a valuable addition to the pharmacological armamentarium for management of | depression | Human | — | Not mentioned. | Magnesium in depression.cited 61× |
| magnesium sulfate | No effect - beneficial effect of | agitated depression | Human | patients with agitated depression | Not mentioned. | Magnesium in depression.cited 61× |
| supplementation with over-the-counter magnesium chloride | Decreases - improves | symptoms of depression | Human | 126 adults diagnosed with and currently experiencing mild-to-moderate symptoms with Patient Health Questionnaire-9 (PHQ-9) scores of 5-19 | 248 mg of elemental magnesium per day. | Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.cited 68× |
| magnesium | Decreases - effective | mild-to-moderate depression | Human | adults | 248 mg of elemental magnesium per day. | Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.cited 68× |
| Daily consumption of 500 mg magnesium oxide tablets for ≥8 wk | Decreases - leads to improvements | depression status | Human | depressed patients suffering from magnesium deficiency | 500 mg magnesium oxide daily (two 250-mg tablets). | Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: A randomized, double-blind, placebo-controlled trial.cited 46× |
| magnesium supplementation | Decreases - improve | depression | Human | — | Not specified | Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression.cited 14× |
| Magnesium supplementation (300 mg daily) | Increases - observed a noteworthy enhancement in | depression score | Human | hospitalized patients with COVID-19 | 300 mg daily | A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients.cited 6× |
| magnesium supplementation | No effect - demonstrated equivocal results concerning its supplementary effectiveness | effectiveness in the treatment of depression | Human | clinical studies | — | The role of magnesium and zinc in depression: similarities and differences.cited 24× |
| magnesium supplementation | Decreases - significantly lower | mean level of anxiety and depression | Human | patients after open-heart surgery | 500 mg daily (two 250-mg magnesium oxide tablets). | Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.cited 9× |
| magnesium supplementation | Increases - could be a valuable addition | standard treatments for depression | HumanAnimal | — | Not specified | Magnesium and depression.cited 46× |
| magnesium deficiency | No effect - inconclusive | depression | Human | — | Not specified | Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications.cited 192× |
| Magnesium-L-threonate (MgT) | Decreases - decreased | depression-like symptoms | Animal | healthy rats | 50 mg/kg, 100 mg/kg, and 150 mg/kg | Neurobehavioral and biochemical effects of magnesium chloride (MgCl2), magnesium sulphate (MgSO4) and magnesium-L-threonate (MgT) supplementation in rats: A dose dependent comparative study.cited 8× |