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Magnesium Orotate and the Microbiome-Gut-Brain Axis Modulation: New Approaches in Psychological Comorbidities of Gastrointestinal Functional Disorders.

Nutrients
January 1, 1970
Cristina Schiopu et al. (12 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to review the efficiency of magnesium orotate therapy and probiotic supplementation in patients with both digestive and psychiatric symptoms, focusing on gut-brain axis modulation.

Results Summary

The abstract suggests magnesium orotate may be effective as an adjuvant in gastroenterological and psychiatric disorders, particularly in cases with overlapping symptoms, but does not provide specific outcome data.

Population

Pediatric and adult patients with gastroenterological and psychiatric symptoms.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (6)
InterventionDirectionEndpointPopulationDosageImpactClaim #
magnesium orotate
neutral
pediatric and adult gastroenterological disorders associated with dysbiosis
-
-
possible adjuvant
#1
magnesium orotate
neutral
psychiatric disorders' treatment, such as major depression and anxiety
-
-
adding
#2
magnesium orotate therapy
neutral
cases with both gastroenterological and psychiatric symptoms
-
-
efficiency
#3
magnesium orotate treatment and probiotic supplementation
neutral
patients with both digestive and psychiatric symptoms
patients with both digestive and psychiatric symptoms
-
targeting
#4
magnesium orotate and probiotics
neutral
both the pediatric and adult communities
pediatric and adult communities
-
compare the efficiency
#5
magnesium orotate and probiotics
neutral
clinical evolution of these patients
these patients
-
focusing on the possibility of gut-brain axis modulation
#6
Abstract

Magnesium orotate has been cited in the medical literature for the past three years as a possible adjuvant in some pediatric and adult gastroenterological disorders associated with dysbiosis. Studies also focus on the possibility of adding magnesium orotate in psychiatric disorders' treatment, such as major depression and anxiety. The most relevant element in these studies is the efficiency of magnesium orotate therapy in cases with both gastroenterological and psychiatric symptoms. This article proposes a literature review, focused on the studies published in the last three years, targeting magnesium orotate treatment and probiotic supplementation in patients with both digestive and psychiatric symptoms. Moreover, this review will compare the efficiency of magnesium orotate and probiotics within both the pediatric and adult communities, focusing on the possibility of gut-brain axis modulation and its involvement in the clinical evolution of these patients.

Medical Subject Headings (MeSH)
AdultBrain-Gut AxisChildGastrointestinal DiseasesHumansMicrobiotaOrotic AcidProbiotics
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality65/10
Citation Metrics
Total Citations20
Citations/Year6.7
Relative Citation Ratio2.80
NIH Percentile83.4%
Research Impact Scores
APT Score0.50
Weight Score1.54
Normalized Score0.63
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