Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D and/or magnesium supplementation | increase | 25(OH)-D levels | obese women with mild to moderate depressive symptoms | - | significant differences | #1 |
vitamin D and/or magnesium supplementation | increase | magnesium levels | obese women with mild to moderate depressive symptoms | - | significant differences | #2 |
vitamin D and/or magnesium supplementation | decrease | TNF-α levels | obese women with mild to moderate depressive symptoms | - | significant differences | #3 |
vitamin D and/or magnesium supplementation | decrease | IL-6 levels | obese women with mild to moderate depressive symptoms | - | significant differences | #4 |
vitamin D and/or magnesium supplementation | increase | BDNF levels | obese women with mild to moderate depressive symptoms | - | significant differences | #5 |
vitamin D and/or magnesium supplementation | no change | hs-CRP levels | obese women with mild to moderate depressive symptoms | - | no significant differences | #6 |
vitamin D and/or magnesium supplementation | no change | SIRT1 levels | obese women with mild to moderate depressive symptoms | - | no significant differences | #7 |
vitamin D and/or magnesium supplementation | decrease | depression score | obese women with mild to moderate depressive symptoms | - | significant reduction | #8 |
vitamin D and/or magnesium supplementation | no change | BDI-II score | obese women with mild to moderate depressive symptoms | - | no significant differences | #9 |
vitamin D plus magnesium supplementation | increase | mood | obese women with mild to moderate depressive symptoms | - | has beneficial influences | #10 |
vitamin D plus magnesium supplementation | increase | serum levels of BDNF | obese women with mild to moderate depressive symptoms | - | has beneficial influences | #11 |
vitamin D plus magnesium supplementation | decrease | inflammation | obese women with mild to moderate depressive symptoms | - | has beneficial influences | #12 |
vitamin D plus magnesium supplementation | increase | SIRT1 | obese women with mild to moderate depressive symptoms | - | has beneficial influences | #13 |
OBJECTIVES: This study aimed to evaluate the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. METHODS: In this trial, the 108 obese women with mild to moderate depressive symptoms were randomly allocated into 4 groups: (1) co- supplementation group ( RESULTS: At the end of the study, ANCOVA demonstrated significant differences between the 4 groups in 25(OH)-D, magnesium, TNF-α, IL-6, and BDNF levels. But, we found no significant differences in terms of hs-CRP and SIRT1 levels. A significant reduction in depression score was observed in 3 intervention groups and also in control group. No significant differences in BDI-II score were shown among the 4 groups at the end of the intervention. CONCLUSION: Vitamin D plus magnesium supplementation in obese women with mild to moderate depressive symptoms has beneficial influences on mood, serum levels of BDNF, inflammation, and SIRT1.